3.4.22.B60: cathepsin L2

This is an abbreviated version, for detailed information about cathepsin L2, go to the full flat file.

Reaction

preference for Arg in the P1 position, Pro is accepted in the P2 position =

Synonyms

cathepsin L2, cathepsin L2 protease, CatL2, CL2, FhCatL2, FhCL2

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.B60 cathepsin L2

Natural Substrates Products

Natural Substrates Products on EC 3.4.22.B60 - cathepsin L2

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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
Boc-AGPR-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
-
-
-
-
?
Boc-VLK-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
-
-
-
-
?
Boc-VPR-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
-
-
-
-
?
Collagen type I + H2O
?
show the reaction diagram
-
cathepsin L2 cleaves collagen type I at 43 sites within the alpha1 chain and 26 sites within the alpha2 chain
-
-
?
collagen type II + H2O
?
show the reaction diagram
-
cathepsin L2 exhibits collagenase activity by cleaving at multiple sites within the alpha1 and alpha2 triple helix regions (Col domains)
-
-
?
tosyl-GPK-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
-
-
-
-
?
tosyl-GPR-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
-
-
-
-
?
Z-Gly-Pro-Gly-Gly-Pro-Ala + H2O
Z-Gly-Pro + Gly-Gly + L-Pro-L-Ala
show the reaction diagram
-
-
-
-
?
Z-Gly-Pro-Leu-Gly-Pro + H2O
Z-Gly-Pro + L-Leu + Gly + L-Pro
show the reaction diagram
-
-
-
-
?
Z-Leu-Arg-NHMe + H2O
?
show the reaction diagram
-
-
-
-
?
Z-Phe-Arg-NHMe + H2O
?
show the reaction diagram
-
-
-
-
?
Z-VVR-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
-
-
-
-
?
additional information
?
-