3.4.22.B60: cathepsin L2
This is an abbreviated version!
For detailed information about cathepsin L2, go to the full flat file.
Word Map on EC 3.4.22.B60
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3.4.22.B60
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fasciola
-
hepatica
-
proteinases
-
fluke
-
helminth
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schistosome
-
trematode
-
l-like
-
excysted
-
collagenolytic
-
diagnostics
-
agriculture
- 3.4.22.B60
- fasciola
- hepatica
- proteinases
- fluke
-
helminth
-
schistosome
-
trematode
-
l-like
-
excysted
-
collagenolytic
- diagnostics
- agriculture
Reaction
preference for Arg in the P1 position, Pro is accepted in the P2 position =
Synonyms
cathepsin L2, cathepsin L2 protease, CatL2, CL2, FhCatL2, FhCL2, FhpCL2
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Reference
Reference on EC 3.4.22.B60 - cathepsin L2
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Dowd, A.J.; Smith, A.M.; McGonigle, S.; Dalton, J.P.
Purification and characterization of a second cathepsin L proteinase secreted by parasitic trematode Fasciola hepatica
Eur. J. Biochem.
223
91-98
1994
Fasciola hepatica (P80342)
Stack, C.M.; Donnelly, S.; Lowther, J.; Xu, W.; Collins, P.R.; Brinen, L.S.; Dalton, J.P.
The major secreted cathepsin L1 protease of the liver fluke, Fasciola hepatica: a Leu-12 to Pro-12 replacement in the nonconserved C-terminal region of the prosegment prevents complete enzyme autoactivation and allows definition of the molecular events in
J. Biol. Chem.
282
16532-16543
2007
Fasciola hepatica
Stack, C.M.; Caffrey, C.R.; Donnelly, S.M.; Seshaadri, A.; Lowther, J.; Tort, J.F.; Collins, P.R.; Robinson, M.W.; Xu, W.; McKerrow, J.H.; Craik, C.S.; Geiger, S.R.; Marion, R.; Brinen, L.S.; Dalton, J.P.
Structural and functional relationships in the virulence-associated cathepsin L proteases of the parasitic liver fluke, Fasciola hepatica
J. Biol. Chem.
283
9896-9908
2008
Fasciola hepatica (Q24940), Fasciola hepatica
Dowd, A.J.; McGonigle, S.; Dalton, J.P.
Fasciola hepatica cathepsin L proteinase cleaves fibrinogen and produces a novel type of fibrin clot
Eur. J. Biochem.
232
241-246
1995
Fasciola hepatica
Berasain, P.; Carmona, C.; Frangione, B.; Dalton, J.P.; Goni, F.
Fasciola hepatica: parasite-secreted proteinases degrade all human IgG subclasses: determination of the specific cleavage sites and identification of the immunoglobulin fragments produced
Exp. Parasitol.
94
99-110
2000
Fasciola hepatica
Smooker, P.M.; Whisstock, J.C.; Irving, J.A.
Siyaguna, S.; Spithill, T.W.: Pike, R.N.: A single amino acid substitution affects substrate specificity in cysteine proteinases from Fasciola hepatica
Protein Sci.
9
2567-2572
2000
Fasciola hepatica
Robinson, M.W.; Dalton, J.P.; Donnelly, S.
Helminth pathogen cathepsin proteases
Trends Biochem. Sci.
33
601-608
2008
Fasciola hepatica (Q24940)
Robinson, M.W.; Tort, J.F.; Lowther, J.; Donnelly, S.M.; Wong, E.; Xu, W.; Stack, C.M.; Padula, M.; Herbert, B.; Dalton, J.P.
Proteomics and phylogenetic analysis of the cathepsin L protease family of the helminth pathogen Fasciola hepatica: expansion of a repertoire of virulence-associated factors
Mol. Cell. Proteomics
7
1111-1123
2008
Fasciola hepatica (Q7JNQ8)
Villa-Mancera, A.; Quiroz-Romero, H.; Correa, D.; Ibarra, F.; Reyes-Perez, M.; Reyes-Vivas, H.; Lopez-Velazquez, G.; Gazarian, K.; Gazarian, T.; Alonso, R.A.
Induction of immunity in sheep to Fasciola hepatica with mimotopes of cathepsin L selected from a phage display library
Parasitology
135
1437-1445
2008
Fasciola hepatica
Sukuru, S.C.; Nigsch, F.; Quancard, J.; Renatus, M.; Chopra, R.; Brooijmans, N.; Mikhailov, D.; Deng, Z.; Cornett, A.; Jenkins, J.L.; Hommel, U.; Davies, J.W.; Glick, M.
A lead discovery strategy driven by a comprehensive analysis of proteases in the peptide substrate space
Protein Sci.
19
2096-2109
2010
Homo sapiens
Norbury, L.J.; Beckham, S.; Pike, R.N.; Grams, R.; Spithill, T.W.; Fecondo, J.V.; Smooker, P.M.
Adult and juvenile Fasciola cathepsin L proteases: different enzymes for different roles
Biochimie
93
604-611
2011
Fasciola hepatica (Q7JNQ8), Fasciola hepatica
Robinson, M.W.; Corvo, I.; Jones, P.M.; George, A.M.; Padula, M.P.; To, J.; Cancela, M.; Rinaldi, G.; Tort, J.F.; Roche, L.; Dalton, J.P.
Collagenolytic activities of the major secreted cathepsin L peptidases involved in the virulence of the helminth pathogen, Fasciola hepatica
PLoS Negl. Trop. Dis.
5
e1012
2011
Fasciola hepatica
Leng, Y.P.; Ma, Y.S.; Li, X.G.; Chen, R.F.; Zeng, P.Y.; Li, X.H.; Qiu, C.F.; Li, Y.P.; Zhang, Z.; Chen, A.F.
L-Homocysteine-induced cathepsin V mediates the vascular endothelial inflammation in hyperhomocysteinaemia
Br. J. Pharmacol.
175
1157-1172
2018
Mus musculus, Mus musculus C57BL/6
Mebius, M.M.; Op Heij, J.M.J.; Tielens, A.G.M.; de Groot, P.G.; Urbanus, R.T.; van Hellemond, J.J.
Fibrinogen and fibrin are novel substrates for Fasciola hepatica cathepsin L peptidases
Mol. Biochem. Parasitol.
221
10-13
2018
Fasciola hepatica (A0A220T1Z2), Fasciola hepatica
Martinez-Sernandez, V.; Perteguer, M.J.; Hernandez-Gonzalez, A.; Mezo, M.; Gonzalez-Warleta, M.; Orbegozo-Medina, R.A.; Romaris, F.; Paniagua, E.; Garate, T.; Ubeira, F.M.
Comparison of recombinant cathepsins L1, L2, and L5 as ELISA targets for serodiagnosis of bovine and ovine fascioliasis
Parasitol. Res.
117
1521-1534
2018
Fasciola hepatica (A0A220T1Z2), Fasciola hepatica
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