3.4.22.B30: calpain 10
This is an abbreviated version!
For detailed information about calpain 10, go to the full flat file.
Word Map on EC 3.4.22.B30
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3.4.22.B30
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calpains
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mellitus
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ucsnp-43
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polycystic
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tcf7l2
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mexican
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kcnj11
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medicine
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mexican-american
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pro12ala
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7-like
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igf2bp2
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haplogenotype
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cdkal1
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drug development
- 3.4.22.B30
- calpains
- mellitus
-
ucsnp-43
-
polycystic
-
tcf7l2
-
mexican
-
kcnj11
- medicine
-
mexican-american
-
pro12ala
-
7-like
-
igf2bp2
-
haplogenotype
- cdkal1
- drug development
Reaction
broad endopeptidase specificity =
Synonyms
calpain 10, calpain-10, CAPN10
ECTree
3.4.22.B30 calpain 10Advanced search results
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results (Substrates Products
Substrates Products on EC 3.4.22.B30 - calpain 10
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
succinyl-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin + H2O
succinyl-Leu-Leu-Val-Tyr + 7-amino-4-methylcoumarin
peptide + H2O
hydrolyzed peptide
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genetic variation in the calpain 10 gene is associated with an increased risk of type II diabetes mellitus in humans
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?
peptide + H2O
hydrolyzed peptide
proteolysis of substrates involved in cytoskeletal remodelling and signal transduction
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?
peptide + H2O
hydrolyzed peptide
proteolysis of substrates involved in cytoskeletal remodelling and signal transduction
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?
peptide + H2O
hydrolyzed peptide
calpain 10 transcripts are rapidly up-regulated in the outer regions of the lens during nuclear cataract formation, but calpain 10 protein is degraded when cataract is present
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?
SLLVY-7-amido-4-methylcoumarin + H2O
SLLVY + 7-amino-4-methylcoumarin
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-
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?
SLLVY-7-amido-4-methylcoumarin + H2O
SLLVY + 7-amino-4-methylcoumarin
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?
SNAP-25 + H2O
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the 54 kDa isoform of calpain-10 proteolyzes SNAP-25, a member of SNARE family of proteins involved in vesicle fusion
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?
SNAP-25 + H2O
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i.e. synaptosome-associated protein of 25000 Da. One of the mechanisms by which arsenite impairs insulin secretion is by decreasing the oscillations of free Ca2+, thus reducing calcium-dependent calpain-10 partial proteolysis of SNAP-25
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?
succinyl-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin + H2O
succinyl-Leu-Leu-Val-Tyr + 7-amino-4-methylcoumarin
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-
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?
succinyl-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin + H2O
succinyl-Leu-Leu-Val-Tyr + 7-amino-4-methylcoumarin
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-
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?
succinyl-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin + H2O
succinyl-Leu-Leu-Val-Tyr + 7-amino-4-methylcoumarin
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?
additional information
?
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mitochondrial calpain 10 is required for cell viability. Calpain 10 levels specifically decrease in aging human kidney tissue when renal function decreases, suggesting that calpain 10 is required for renal function and is a biomarker of the aging kidney
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?
additional information
?
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none of the calpain-10 proteins purified from different sources has putative proteolytic activity under in vitro conditions when examined using different peptide substrates, including more than 70 in vitro translated, radiolabeled oligopeptides. Calpain-10 may require a special intracellular localization or interacting partner(s) to acquire proteolytic activity, or it may functions by interacting with other proteins rather than through its proteolytic activity
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?
additional information
?
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mitochondrial calpain 10 is required for cell viability. Calpain 10 levels specifically decreases in aging mouse kidney tissue when renal function decreases, suggesting that calpain 10 is required for renal function and is a biomarker of the aging kidney
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?
additional information
?
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DAP13 (13 kDa differentiation-associated protein) is not hydrolyzed by calpain 10 in the presence of CaCl2
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?
additional information
?
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DAP13 (13 kDa differentiation-associated protein) is not hydrolyzed by calpain 10 in the presence of CaCl2
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?
additional information
?
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mitochondrial calpain 10 is required for cell viability. Calpain 10 levels specifically decrease in aging rat kidney tissue when renal function decreases, suggesting that calpain 10 is required for renal function and is a biomarker of the aging kidney
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?
