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Literature summary for 3.4.22.B30 extracted from

  • Ma, H.; Fukiage, C.; Kim, Y.H.; Duncan, M.K.; Reed, N.E.
    Sih, M.; Azuma, M.; Shearer, T.R.: Characterization and expression of calpain 10. A novel ubiquitous calpain within nuclear localization (2001), J. Biol. Chem., 276, 28525-28531.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in the baculovirus system Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm cytoplasm of epithelium and transition zone Mus musculus 5737
-
cytosol cultured alphaTN4-1 lens epithelial cells Mus musculus 5829
-
nucleus cultured alphaTN4-1 lens epithelial cells Mus musculus 5634
-
plasma membrane
-
Homo sapiens 5886
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
74527
-
x * 74527, calculation from nucleotide sequence Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
peptide + H2O Homo sapiens genetic variation in the calpain 10 gene is associated with an increased risk of type II diabetes mellitus in humans hydrolyzed peptide
-
?
peptide + H2O Rattus norvegicus calpain 10 transcripts are rapidly up-regulated in the outer regions of the lens during nuclear cataract formation, but calpain 10 protein is degraded when cataract is present hydrolyzed peptide
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-
Rattus norvegicus Q9ES66
-
-

Source Tissue

Source Tissue Comment Organism Textmining
alphaTN4-1 cell
-
Mus musculus
-
brain
-
Mus musculus
-
brain
-
Homo sapiens
-
brain highest level of expression in young rats Rattus norvegicus
-
heart
-
Mus musculus
-
heart
-
Homo sapiens
-
heart
-
Rattus norvegicus
-
kidney
-
Rattus norvegicus
-
lens
-
Mus musculus
-
lens
-
Rattus norvegicus
-
lens lens epithelium, outer fiber cells of lens Homo sapiens
-
liver
-
Rattus norvegicus
-
lung
-
Rattus norvegicus
-
muscle
-
Rattus norvegicus
-
retina
-
Mus musculus
-
retina
-
Homo sapiens
-
retina
-
Rattus norvegicus
-
skeletal muscle
-
Mus musculus
-
skeletal muscle
-
Homo sapiens
-
skeletal muscle
-
Rattus norvegicus
-
spleen
-
Rattus norvegicus
-
stomach
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
peptide + H2O genetic variation in the calpain 10 gene is associated with an increased risk of type II diabetes mellitus in humans Homo sapiens hydrolyzed peptide
-
?
peptide + H2O calpain 10 transcripts are rapidly up-regulated in the outer regions of the lens during nuclear cataract formation, but calpain 10 protein is degraded when cataract is present Rattus norvegicus hydrolyzed peptide
-
?

Subunits

Subunits Comment Organism
? x * 74527, calculation from nucleotide sequence Rattus norvegicus