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Literature summary for 3.4.22.B30 extracted from
- Chronic high glucose downregulates mitochondrial calpain 10 and contributes to renal cell death and diabetes-induced renal injury (2012), Kidney Int., 81, 391-400.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| calpeptin | - |
Mus musculus |  |
| calpeptin | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Mus musculus | 5737 | - |
| cytoplasm | - |
Rattus norvegicus | 5737 | - |
| mitochondrion | - |
Mus musculus | 5739 | - |
| mitochondrion | - |
Rattus norvegicus | 5739 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 75000 | - |
x * 75000, SDS-PAGE | Mus musculus |
| 75000 | - |
x * 75000, SDS-PAGE | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP synthase beta + H2O | Mus musculus | - |
? | - |
? | |
| ATP synthase beta + H2O | Rattus norvegicus | - |
? | - |
? | |
| NDUFB8 + H2O | Mus musculus | - |
? | - |
? | |
| NDUFB8 + H2O | Rattus norvegicus | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Mus musculus | - |
| kidney | - |
Rattus norvegicus | - |
| renal proximal tubule | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP synthase beta + H2O | - |
Mus musculus | ? | - |
? | |
| ATP synthase beta + H2O | - |
Rattus norvegicus | ? | - |
? | |
| NDUFB8 + H2O | - |
Mus musculus | ? | - |
? | |
| NDUFB8 + H2O | - |
Rattus norvegicus | ? | - |
? | |
| succinyl-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin + H2O | - |
Mus musculus | succinyl-Leu-Leu-Val-Tyr + 7-amino-4-methylcoumarin | - |
? | |
| succinyl-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin + H2O | - |
Rattus norvegicus | succinyl-Leu-Leu-Val-Tyr + 7-amino-4-methylcoumarin | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 75000, SDS-PAGE | Mus musculus |
| ? | x * 75000, SDS-PAGE | Rattus norvegicus |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Rattus norvegicus | chronic high glucose down-regulates mitochondrial calpain 10. High glucose (17 mM) decreases mitochondrial calpain 10 mRNA and protein at 96 h compared with cells incubated with 0 or 5 mM glucose or 17 mM D-mannitol. Renal calpain 10 protein and mRNA are specifically decreased in streptozotocin-induced diabetic rats with kidney dysfunction | down |
| Mus musculus | renal calpain 10 protein and mRNA are specifically decreased in ob/ob diabetic mice | down |
| Rattus norvegicus | mitochondrial calpain activity does not change with 5mM glucose or 17 mM D-mannitol | additional information |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | knockdown of calpain 10 results in decreased renal function as evidenced by increased serum creatinine, and increased caspase 3 cleavage | Rattus norvegicus |
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