3.4.22.B30: calpain 10
This is an abbreviated version!
For detailed information about calpain 10, go to the full flat file.
Word Map on EC 3.4.22.B30
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3.4.22.B30
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calpains
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mellitus
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ucsnp-43
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polycystic
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tcf7l2
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mexican
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kcnj11
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medicine
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mexican-american
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pro12ala
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7-like
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igf2bp2
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haplogenotype
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cdkal1
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drug development
- 3.4.22.B30
- calpains
- mellitus
-
ucsnp-43
-
polycystic
-
tcf7l2
-
mexican
-
kcnj11
- medicine
-
mexican-american
-
pro12ala
-
7-like
-
igf2bp2
-
haplogenotype
- cdkal1
- drug development
Reaction
broad endopeptidase specificity =
Synonyms
calpain 10, calpain-10, CAPN10
ECTree
3.4.22.B30 calpain 10Advanced search results
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results (Expression
Expression on EC 3.4.22.B30 - calpain 10
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EXPRESSION 
ORGANISM
UNIPROT
LITERATURE
calpain-10 expression is elevated by 64% in pancreatic islets from patients with type 2 diabetes compared with non-diabetic donors
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calpain-10 is overexpressed and activated through the inhibition of ryanodine receptor 2 under hypoglycemic and high fatty acid conditions, causing caspase-3-independent beta-cell death
chronic high glucose down-regulates mitochondrial calpain 10. High glucose (17 mM) decreases mitochondrial calpain 10 mRNA and protein at 96 h compared with cells incubated with 0 or 5 mM glucose or 17 mM D-mannitol. Renal calpain 10 protein and mRNA are specifically decreased in streptozotocin-induced diabetic rats with kidney dysfunction
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mitochondrial calpain activity does not change with 5mM glucose or 17 mM D-mannitol
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renal calpain 10 protein and mRNA are specifically decreased in ob/ob diabetic mice
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