3.4.22.47: gingipain K

This is an abbreviated version!
For detailed information about gingipain K, go to the full flat file.

Reaction

endopeptidase with strict specificity for lysyl bonds =

Synonyms

gingipain, gingipain K, HbR, K-gingipain, K-specific gingipain protease, KGP, Lys-gingipain, Lys-specific cysteine proteinase gingipain, lysine gingipain, lysine-sepcific cysteine protease, lysine-specific gingipain, lysine-specific gingipain K, lysine-specific gingipain protease, lysine-specific gingipain proteinase, lysine-specific proteinase, porphypain, PrtP proteinase

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.22 Cysteine endopeptidases

                3.4.22.47 gingipain K

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Results	in table
15	Activating Compound
59	AA Sequence
7	Application
1	CAS Registry Number
5	Cloned(Commentary)
3	Crystallization (Commentary)
14	General Information
1	General Stability
53	Inhibitors
3	Ki Value [mM]
7	KM Value [mM]
14	Localization
1	Metals/Ions
10	Molecular Weight [Da]
33	Natural Substrates/ Products (Substrates)
126	Organism
7	PDB ID
21	pH Optimum
1	pH Range
3	pH Stability
4	Posttranslational Modification
18	Protein Variants
11	Purification (Commentary)
3	Reaction
1	Reaction Type
65	Reference
6	Source Tissue
3	Specific Activity [micromol/min/mg]
105	Substrates and Products (Substrate)
15	Subunits
93	Synonyms
19	Temperature Optimum [°C]
6	Temperature Stability [°C]
1	Turnover Number [1/s]

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Cloned on EC 3.4.22.47 - gingipain K

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CLONED (Commentary)

ORGANISM

UNIPROT

LITERATURE

-

Porphyromonas gingivalis

-

667031

expression in Sf9 insect cells

Porphyromonas gingivalis

P72197

638847

expression of wild-type and mutant enzymes in murine ST2 osteoblastic/stromal cells

Porphyromonas gingivalis

-

700531

HbR domain is recombinantly expressed in Escherichia coli

Porphyromonas gingivalis

-

708956

the gene fragment encoding the K2 domain (Ala1157-Gly1334) of Kgp from Porphyromonas gingivalis W83 is cloned into a modified vector pET-32a. The constructed plasmid is transformed into Escherichia coli BL21(DE3) competent cells for protein expression

Porphyromonas gingivalis

-

710002