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3.4.22.47: gingipain K

This is an abbreviated version!
For detailed information about gingipain K, go to the full flat file.

Word Map on EC 3.4.22.47

Reaction

endopeptidase with strict specificity for lysyl bonds =

Synonyms

gingipain, gingipain K, HbR, K-gingipain, K-specific gingipain protease, KGP, Lys-gingipain, Lys-specific cysteine proteinase gingipain, lysine gingipain, lysine-sepcific cysteine protease, lysine-specific gingipain, lysine-specific gingipain K, lysine-specific gingipain protease, lysine-specific gingipain proteinase, lysine-specific proteinase, porphypain, PrtP proteinase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.47 gingipain K

Reference

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Reference on EC 3.4.22.47 - gingipain K

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Potempa, J.; Pike, R.; Travis, J.
The multiple forms of trypsin-like activity present in various strains of Porphyromonas gingivalis are due to the presence of either Arg-gingipain or Lys-gingipain
Infect. Immun.
63
1176-1182
1995
Porphyromonas gingivalis, Porphyromonas gingivalis H66
Manually annotated by BRENDA team
Bedi, G.S.
Purification and characterization of lysine- and arginine-specific gingivain proteases from Porphyromonas gingivalis
Prep. Biochem.
24
251-261
1994
Porphyromonas gingivalis
Manually annotated by BRENDA team
Pike, R.; McGraw, W.; Potempa, J.; Travis, J.
Lysine- and arginine-specific proteinases from Porphyromonas gingivalis. Isolation, characterization, and evidence for the existence of complexes with hemagglutinins
J. Biol. Chem.
269
406-411
1994
Porphyromonas gingivalis, Porphyromonas gingivalis H66
Manually annotated by BRENDA team
Potempa, J.; Travis, J.
Porphyromonas gingivalis proteinases in periodontitis, a review
Acta Biochim. Pol.
43
455-465
1996
Porphyromonas gingivalis
Manually annotated by BRENDA team
Pavloff, N.; Pemberton, P.A.; Potempa, J.; Chen, W.C.; Pike, R.N.; Prochazka, V.; Kiefer, M.C.; Travis, J.; Barr, P.J.
Molecular cloning and characterization of Porphyromonas gingivalis lysine-specific gingipain. A new member of an emerging family of pathogenic bacterial cysteine proteinases
J. Biol. Chem.
272
1595-1600
1997
Porphyromonas gingivalis (P72197), Porphyromonas gingivalis
Manually annotated by BRENDA team
Abe, N.; Kadowaki, T.; Okamoto, K.; Nakayama, K.; Ohishi, M.; Yamamoto, K.
Biochemical and functional properties of lysine-specific cysteine proteinase (Lys-gingipain) as a virulence factor of Porphyromonas gingivalis in periodontal disease
J. Biochem.
123
305-312
1998
Porphyromonas gingivalis
Manually annotated by BRENDA team
Fujimura, S.; Hirai, K.; Shibata, Y.; Nakayama, K.; Nakamura, T.
Comparative properties of envelope-associated arginine-gingipains and lysine-gingipain of Porphyromonas gingivalis
FEMS Microbiol. Lett.
163
173-179
1998
Porphyromonas gingivalis
Manually annotated by BRENDA team
Banbula, A.; Bugno, M.; Kuster, A.; Heinrich, P.C.; Travis, J.; Potempa, J.
Rapid and efficient inactivation of IL-6 gingipains, lysine- and arginine-specific proteinases from Porphyromonas Gingivalis
Biochem. Biophys. Res. Commun.
261
598-602
1999
Porphyromonas gingivalis
Manually annotated by BRENDA team
Sroka, A.; Sztukowska, M.; Potempa, J.; Travis, J.; Genco, C.A.
Degradation of host heme proteins by lysine- and arginine-specific cysteine proteinases (gingipains) of Porphyromonas gingivalis
J. Bacteriol.
183
5609-5616
2001
Porphyromonas gingivalis
Manually annotated by BRENDA team
Olczak, T.; Dixon, D.W.; Genco, C.A.
Binding specificity of the Porphyromonas gingivalis heme and hemoglobin receptor HmuR, gingipain K, and gingipain R1 for heme, porphyrins, and metalloporphyrins
J. Bacteriol.
183
5599-5608
2001
Porphyromonas gingivalis, Porphyromonas gingivalis HG66
Manually annotated by BRENDA team
Curtis, M.A.; Opoku, J.A.; Rangarajan, M.; Gallagher, A.; Sterne, J.A.C.; reid, C.R.; Evans, H.E.A.; Samuelsson, B.
Attenuation of the virulence of Porphyromonas gingivalis by using a specific synthetic Kgp protease inhibitor
Infect. Immun.
70
6968-6975
2002
Porphyromonas gingivalis
Manually annotated by BRENDA team
Nassar, H.; Chou, H.H.; Khlgatian, M.; Gibson, F.C., 3rd; Van Dyke, T.E.; Genco, C.A.
Role for fimbriae and lysine-specific cysteine proteinase gingipain K in expression of interleukin-8 and monocyte chemoattractant protein in Porphyromonas gingivalis-infected endothelial cells
Infect. Immun.
70
268-276
2002
Porphyromonas gingivalis
Manually annotated by BRENDA team
Baba, A.; Kadowaki, T.; Asao, T.; Yamamoto, K.
Roles for Arg- and Lys-gingipains in the disruption of cytokine responses and loss of viability of human endothelial cells by Porphyromonas gingivalis infection
Biol. Chem.
383
1223-1230
2002
Porphyromonas gingivalis
Manually annotated by BRENDA team
Simpsonv, W.; Olczak, T.; Genco, C.A.
Lysine-specific gingipain K and heme/hemoglobin receptor HmuR are involved in heme utilization in Porphyromonas gingivalis
Acta Biochim. Pol.
51
253-262
2004
Porphyromonas gingivalis
Manually annotated by BRENDA team
Smalley, J.W.; Thomas, M.F.; Birss, A.J.; Withnall, R.; Silver, J.
A combination of both arginine- and lysine-specific gingipain activity of Porphyromonas gingivalis is necessary for the generation of the micro-oxo bishaem-containing pigment from haemoglobin
Biochem. J.
379
833-840
2004
Porphyromonas gingivalis
Manually annotated by BRENDA team
Abe, N.; Baba, A.; Takii, R.; Nakayama, K.; Kamaguchi, A.; Shibata, Y.; Abiko, Y.; Okamoto, K.; Kadowaki, T.; Yamamoto, K.
Roles of Arg- and Lys-gingipains in coaggregation of Porphyromonas gingivalis: identification of its responsible molecules in translation products of rgpA, kgp, and hagA genes
Biol. Chem.
385
1041-1047
2004
Porphyromonas gingivalis
Manually annotated by BRENDA team
Liu, X.; Sroka, A.; Potempa, J.; Genco, C.A.
Coordinate expression of the Porphyromonas gingivalis lysine-specific gingipain proteinase, Kgp, arginine-specific gingipain proteinase, RgpA, and the heme/hemoglobin receptor, HmuR
Biol. Chem.
385
1049-1057
2004
Porphyromonas gingivalis
Manually annotated by BRENDA team
Mezyk-Kopec, R.; Bzowska, M.; Potempa, J.; Bzowska, M.; Jura, N.; Sroka, A.; Black, R.A.; Bereta, J.
Inactivation of membrane tumor necrosis factor alpha by gingipains from Porphyromonas gingivalis
Infect. Immun.
73
1506-1514
2005
Porphyromonas gingivalis
Manually annotated by BRENDA team
Bialas, A.; Grembecka, J.; Krowarsch, D.; Otlewski, J.; Potempa, J.; Mucha, A.
Exploring the Sn binding pockets in gingipains by newly developed inhibitors: structure-based design, chemistry, and activity
J. Med. Chem.
49
1744-1753
2006
Porphyromonas gingivalis, Porphyromonas gingivalis HG66
Manually annotated by BRENDA team
Kishimoto, M.; Yoshimura, A.; Naito, M.; Okamoto, K.; Yamamoto, K.; Golenbock, D.T.; Hara, Y.; Nakayama, K.
Gingipains inactivate a cell surface ligand on Porphyromonas gingivalis that induces TLR2-and TLR4-independent signaling
Microbiol. Immunol.
50
315-325
2006
Porphyromonas gingivalis
Manually annotated by BRENDA team
Sztukowska, M.; Sroka, A.; Bugno, M.; Banbula, A.; Takahashi, Y.; Pike, R.N.; Genco, C.A.; Travis, J.; Potempa, J.
The C-terminal domains of the gingipain K polyprotein are necessary for assembly of the active enzyme and expression of associated activities
Mol. Microbiol.
54
1393-1408
2004
Porphyromonas gingivalis
Manually annotated by BRENDA team
Cronan, C.A.; Potempa, J.; Travis, J.; Mayo, J.A.
Inhibition of Porphyromonas gingivalis proteinases (gingipains) by chlorhexidine: synergistic effect of Zn(II)
Oral Microbiol. Immunol.
21
212-217
2006
Porphyromonas gingivalis
Manually annotated by BRENDA team
Smalley, J.W.; Birss, A.J.; Szmigielski, B.; Potempa, J.
Sequential action of R- and K-specific gingipains of Porphyromonas gingivalis in the generation of the haem-containing pigment from oxyhemoglobin
Arch. Biochem. Biophys.
465
44-49
2007
Porphyromonas gingivalis
Manually annotated by BRENDA team
Ishida, Y.; Hu, J.; Sakai, E.; Kadowaki, T.; Yamamoto, K.; Tsukuba, T.; Kato, Y.; Nakayama, K.; Okamoto, K.
Determination of active site of lysine-specific cysteine proteinase (Lys-gingipain) by use of a Porphyromonas gingivalis plasmid system
Arch. Oral Biol.
56
538-544
2008
Porphyromonas gingivalis
Manually annotated by BRENDA team
Slaney, J.M.; Gallagher, A.; Aduse-Opoku, J.; Pell, K.; Curtis, M.A.
Mechanisms of resistance of Porphyromonas gingivalis to killing by serum complement
Infect. Immun.
74
5352-5361
2006
Porphyromonas gingivalis
Manually annotated by BRENDA team
Hashimoto, M.; Kadowaki, T.; Tsukuba, T.; Yamamoto, K.
Selective proteolysis of apolipoprotein B-100 by Arg-gingipain mediates atherosclerosis progression accelerated by bacterial exposure
J. Biochem.
140
713-723
2006
Porphyromonas gingivalis
Manually annotated by BRENDA team
Smalley, J.W.; Birss, A.J.; Szmigielski, B.; Potempa, J.
The HA2 haemagglutinin domain of the lysine-specific gingipain (Kgp) of Porphyromonas gingivalis promotes micro-oxo bishaem formation from monomeric iron(III) protoporphyrin IX
Microbiology
152
1839-1845
2006
Porphyromonas gingivalis
Manually annotated by BRENDA team
Yasuhara, R.; Miyamoto, Y.; Takami, M.; Imamura, T.; Potempa, J.; Yoshimura, K.; Kamijo, R.
Lysine-specific gingipain promotes lipopolysaccharide- and active-vitamin D3-induced osteoclast differentiation by degrading osteoprotegerin
Biochem. J.
419
159-166
2009
Porphyromonas gingivalis, Porphyromonas gingivalis HG66
Manually annotated by BRENDA team
Smalley, J.W.; Birss, A.J.; Szmigielski, B.; Potempa, J.
Mechanism of methaemoglobin breakdown by the lysine-specific gingipain of the periodontal pathogen Porphyromonas gingivalis
Biol. Chem.
389
1235-1238
2008
Porphyromonas gingivalis
Manually annotated by BRENDA team
Uehara, A.; Imamura, T.; Potempa, J.; Travis, J.; Takada, H.
Gingipains from Porphyromonas gingivalis synergistically induce the production of proinflammatory cytokines through protease-activated receptors with Toll-like receptor and NOD1/2 ligands in human monocytic cells
Cell. Microbiol.
10
1181-1189
2008
Porphyromonas gingivalis
Manually annotated by BRENDA team
Ishiguro, I.; Saiki, K.; Konishi, K.
PG27 is a novel membrane protein essential for a Porphyromonas gingivalis protease secretion system
FEMS Microbiol. Lett.
292
261-267
2009
Porphyromonas gingivalis, Porphyromonas gingivalis W83
Manually annotated by BRENDA team
Uehara, A.; Naito, M.; Imamura, T.; Potempa, J.; Travis, J.; Nakayama, K.; Takada, H.
Dual regulation of interleukin-8 production in human oral epithelial cells upon stimulation with gingipains from Porphyromonas gingivalis
J. Med. Microbiol.
57
500-507
2008
Porphyromonas gingivalis, Porphyromonas gingivalis HG66
Manually annotated by BRENDA team
Bania, J.; Kubiak, A.; Wojtachnio, K.; Polanowski, A.
Pancreatic secretory trypsin inhibitor acts as an effective inhibitor of cysteine proteinases gingipains from Porphyromonas gingivalis
J. Periodont. Res.
43
232-236
2008
Porphyromonas gingivalis
Manually annotated by BRENDA team
Kato, T.; Tsuda, T.; Inaba, H.; Kawai, S.; Okahashi, N.; Shibata, Y.; Abiko, Y.; Amano, A.
Porphyromonas gingivalis gingipains cause G(1) arrest in osteoblastic/stromal cells
Oral Microbiol. Immunol.
23
158-164
2008
Porphyromonas gingivalis, Porphyromonas gingivalis ATCC 33277
Manually annotated by BRENDA team
Stathopoulou, P.G.; Benakanakere, M.R.; Galicia, J.C.; Kinane, D.F.
The host cytokine response to Porphyromonas gingivalis is modified by gingipains
Oral Microbiol. Immunol.
24
11-17
2009
Porphyromonas gingivalis
Manually annotated by BRENDA team
Taiyoji, M.; Shitomi, Y.; Taniguchi, M.; Saitoh, E.; Ohtsubo, S.
Identification of proteinaceous inhibitors of a cysteine proteinase (an Arg-specific gingipain) from Porphyromonas gingivalis in rice grain, using targeted-proteomics approaches
J. Proteome Res.
8
5165-5174
2009
Porphyromonas gingivalis
Manually annotated by BRENDA team
Kantyka, T.; Latendorf, T.; Wiedow, O.; Bartels, J.; Glaeser, R.; Dubin, G.; Schroeder, J.M.; Potempa, J.; Meyer-Hoffert, U.
Elafin is specifically inactivated by RgpB from Porphyromonas gingivalis by distinct proteolytic cleavage
Biol. Chem.
390
1313-1320
2009
Porphyromonas gingivalis (B2RLK2)
Manually annotated by BRENDA team
Stathopoulou, P.; Galicia, J.; Benakanakere, M.; Garcia, C.; Potempa, J.; Kinane, D.
Porphyromonas gingivalis induce apoptosis in human gingival epithelial cells through a gingipain-dependent mechanism
BMC Microbiol.
9
107
2009
Porphyromonas gingivalis
Manually annotated by BRENDA team
Kuboniwa, M.; Amano, A.; Hashino, E.; Yamamoto, Y.; Inaba, H.; Hamada, N.; Nakayama, K.; Tribble, G.D.; Lamont, R.J.; Shizukuishi, S.
Distinct roles of long/short fimbriae and gingipains in homotypic biofilm development by Porphyromonas gingivalis
BMC Microbiol.
9
105
2009
Porphyromonas gingivalis
Manually annotated by BRENDA team
Saiki, K.; Konishi, K.
The role of Sov protein in the secretion of gingipain protease virulence factors of Porphyromonas gingivalis
FEMS Microbiol. Lett.
302
166-174
2010
Porphyromonas gingivalis
Manually annotated by BRENDA team
Haruyama, K.; Yoshimura, A.; Naito, M.; Kishimoto, M.; Shoji, M.; Abiko, Y.; Hara, Y.; Nakayama, K.
Identification of a gingipain-sensitive surface ligand of Porphyromonas gingivalis that induces Toll-like receptor 2- and 4-independent NF-kappaB activation in CHO cells
Infect. Immun.
77
4414-4420
2009
Porphyromonas gingivalis
Manually annotated by BRENDA team
Furuta, N.; Takeuchi, H.; Amano, A.
Entry of Porphyromonas gingivalis outer membrane vesicles into epithelial cells causes cellular functional impairment
Infect. Immun.
77
4761-4770
2009
Porphyromonas gingivalis
Manually annotated by BRENDA team
Nhien, N.T.; Huy, N.T.; Naito, M.; Oida, T.; Uyen, D.T.; Huang, M.; Kikuchi, M.; Harada, S.; Nakayama, K.; Hirayama, K.; Kamei, K.
Neutralization of toxic haem by Porphyromonas gingivalis haemoglobin receptor
J. Biochem.
147
317-325
2010
Porphyromonas gingivalis
Manually annotated by BRENDA team
Fitzpatrick, R.E.; Aprico, A.; Wijeyewickrema, L.C.; Pagel, C.N.; Wong, D.M.; Potempa, J.; Mackie, E.J.; Pike, R.N.
High molecular weight gingipains from Porphyromonas gingivalis induce cytokine responses from human macrophage-like cells via a nonproteolytic mechanism
J. Innate Immun.
1
109-117
2009
Porphyromonas gingivalis
Manually annotated by BRENDA team
Inomata, M.; Ishihara, Y.; Matsuyama, T.; Imamura, T.; Maruyama, I.; Noguchi, T.; Matsushita, K.
Degradation of vascular endothelial thrombomodulin by arginine- and lysine-specific cysteine proteases from Porphyromonas gingivalis
J. Periodontol.
80
1511-1517
2009
Porphyromonas gingivalis
Manually annotated by BRENDA team
Giacaman, R.A.; Asrani, A.C.; Ross, K.F.; Herzberg, M.C.
Cleavage of protease-activated receptors on an immortalized oral epithelial cell line by Porphyromonas gingivalis gingipains
Microbiology
155
3238-3246
2009
Porphyromonas gingivalis
Manually annotated by BRENDA team
Li, N.; Yun, P.; Nadkarni, M.; Ghadikolaee, N.; Nguyen, K.; Lee, M.; Hunter, N.; Collyer, C.
Structure determination and analysis of a haemolytic gingipain adhesin domain from Porphyromonas gingivalis
Mol. Microbiol.
76
861-873
2010
Porphyromonas gingivalis
Manually annotated by BRENDA team
Mahtout, H.; Chandad, F.; Rojo, J.M.; Grenier, D.
Porphyromonas gingivalis mediates the shedding and proteolysis of complement regulatory protein CD46 expressed by oral epithelial cells
Oral Microbiol. Immunol.
24
396-400
2009
Porphyromonas gingivalis
Manually annotated by BRENDA team
Toh, E.C.; Dashper, S.G.; Huq, N.L.; Attard, T.J.; OBrien-Simpson, N.M.; Chen, Y.Y.; Cross, K.J.; Stanton, D.P.; Paolini, R.A.; Reynolds, E.C.
Porphyromonas gingivalis cysteine proteinase inhibition by kappa-casein peptides
Antimicrob. Agents Chemother.
55
1155-1161
2011
Porphyromonas gingivalis
Manually annotated by BRENDA team
Dashper, S.G.; Pan, Y.; Veith, P.D.; Chen, Y.Y.; Toh, E.C.; Liu, S.W.; Cross, K.J.; Reynolds, E.C.
Lactoferrin inhibits Porphyromonas gingivalis proteinases and has sustained biofilm inhibitory activity
Antimicrob. Agents Chemother.
56
1548-1556
2012
Porphyromonas gingivalis
Manually annotated by BRENDA team
Vincents, B.; Guentsch, A.; Kostolowska, D.; von Pawel-Rammingen, U.; Eick, S.; Potempa, J.; Abrahamson, M.
Cleavage of IgG1 and IgG3 by gingipain K from Porphyromonas gingivalis may compromise host defense in progressive periodontitis
FASEB J.
25
3741-3750
2011
Porphyromonas gingivalis
Manually annotated by BRENDA team
Maisetta, G.; Brancatisano, F.; Esin, S.; Campa, M.; Batoni, G.
Gingipains produced by Porphyromonas gingivalis ATCC49417 degrade human-beta-defensin 3 and affect peptides antibacterial activity in vitro
Peptides
32
1073-1077
2011
Porphyromonas gingivalis
Manually annotated by BRENDA team
Smalley, J.; Byrne, D.; Birss, A.; Wojtowicz, H.; Sroka, A.; Potempa, J.; Olczak, T.
HmuY haemophore and gingipain proteases constitute a unique syntrophic system of haem acquisition by Porphyromonas gingivalis
PLoS ONE
6
e17182
2011
Porphyromonas gingivalis
Manually annotated by BRENDA team
Pomowski, A.; Uson, I.; Nowakowska, Z.; Veillard, F.; Sztukowska, M.N.; Guevara, T.; Goulas, T.; Mizgalska, D.; Nowak, M.; Potempa, B.; Huntington, J.A.; Potempa, J.; Gomis-Rueth, F.X.
Structural insights unravel the zymogenic mechanism of the virulence factor gingipain K from Porphyromonas gingivalis, a causative agent of gum disease from the human oral microbiome
J. Biol. Chem.
292
5724-5735
2017
Porphyromonas gingivalis (Q51817), Porphyromonas gingivalis, Porphyromonas gingivalis W83 (Q51817)
Manually annotated by BRENDA team
Guevara, T.; Rodriguez-Banqueri, A.; Lasica, A.M.; Ksiazek, M.; Potempa, B.A.; Potempa, J.; Gomis-Rueth, F.X.
Structural determinants of inhibition of Porphyromonas gingivalis gingipain K by KYT-36, a potent, selective, and bioavailable peptidase inhibitor
Sci. Rep.
9
4935
2019
Porphyromonas gingivalis (Q51817), Porphyromonas gingivalis, Porphyromonas gingivalis W83 (Q51817)
Manually annotated by BRENDA team