Cloned (Comment) | Organism |
---|---|
expression of wild-type and mutant enzymes in murine ST2 osteoblastic/stromal cells | Porphyromonas gingivalis |
Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of enzyme-deficient mutants KDP136 with DELTArgpADELTArgpBDELTAkgp, and KDP129 with DELTArgpADELTArgpB. The mutants do not, in contrast to the wild-type enzyme, inhibit cellular proliferation and don not arrest the cell cycle in the G0/G1 phase as well as decrease the expression levels of the cell-cycle regulatory molecules cyclin D and cyclin E in murine ST2 cells, overview | Porphyromonas gingivalis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Porphyromonas gingivalis | gingipains reduce cyclin expression and cause early G1 arrest, leading to the inhibition of cellular proliferation in murine ST2 osteoblastic/stromal cells, overview | ? | - |
? | |
additional information | Porphyromonas gingivalis ATCC 33277 | gingipains reduce cyclin expression and cause early G1 arrest, leading to the inhibition of cellular proliferation in murine ST2 osteoblastic/stromal cells, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Porphyromonas gingivalis | - |
strain ATCC33277 | - |
Porphyromonas gingivalis ATCC 33277 | - |
strain ATCC33277 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | gingipains reduce cyclin expression and cause early G1 arrest, leading to the inhibition of cellular proliferation in murine ST2 osteoblastic/stromal cells, overview | Porphyromonas gingivalis | ? | - |
? | |
additional information | gingipains reduce cyclin expression and cause early G1 arrest, leading to the inhibition of cellular proliferation in murine ST2 osteoblastic/stromal cells, overview | Porphyromonas gingivalis ATCC 33277 | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
gingipain K | - |
Porphyromonas gingivalis |
KGP | - |
Porphyromonas gingivalis |