3.4.21.B43: kallikrein 12

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For detailed information about kallikrein 12, go to the full flat file.

Word Map on EC 3.4.21.B43

3.4.21.B43

kallikreins

klk8

atopic

dermatitis

kazal-type

diagnostics

kallikrein-like

Reaction

proteolytic cleavage of polypeptides =

Synonyms

hK12, K12, kallikrein 12, kallikrein-related peptidase 12, KLK12, S01.020

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.21 Serine endopeptidases

3.4.21.B43 kallikrein 12

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Results	in table
1	Activating Compound
1	AA Sequence
3	Application
2	CAS Registry Number
5	Cloned(Commentary)
101	Disease/ Diagnostics
3	Expression
11	General Information
2	IC50 Value
12	Inhibitors
7	KM Value [mM]
1	Localization
3	Metals/Ions
4	Molecular Weight [Da]
13	Natural Substrates/ Products (Substrates)
2	Organic Solvent Stability
16	Organism
5	pH Optimum
1	pH Stability
1	Posttranslational Modification
2	Purification (Commentary)
2	Reaction
2	Reaction Type
16	Reference
52	Source Tissue
2	Storage Stability
35	Substrates and Products (Substrate)
1	Subunits
23	Synonyms
4	Temperature Optimum [°C]
10	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 3.4.21.B43 - kallikrein 12

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3,4-dichloroisocoumarin

Homo sapiens

strong inhibitor at 0.25 mM

678534

alpha1-antitrypsin

Homo sapiens

less than 50% inhibition at 5fold molecular inhibitor excess

alpha2-antiplasmin

antithrombin-III

less than 50% inhibition at 5fold molecular inhibitor excess

678528

Aprotinin

Homo sapiens

weak inhibition at 0.02 mM

678534

benzamidine

Homo sapiens

strong inhibitor at 5 mM

C1 inhibitor

NaCl

activity is reduced by approximately 30% in the presence of 0.8 M NaCl

Protein C inhibitor

Zn2+

10 mM Zn2+ is sufficient to inhibit 50% of the KLK12 enzyme activity, more than 95% suppression can be achieved by 0.2 mM Zn2+

678534

additional information

2 entries