3.4.21.B43: kallikrein 12

This is an abbreviated version!
For detailed information about kallikrein 12, go to the full flat file.

Reaction

proteolytic cleavage of polypeptides =

Synonyms

hK12, K12, kallikrein 12, kallikrein-related peptidase 12, KLK12, S01.020

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.B43 kallikrein 12

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1	Activating Compound
1	AA Sequence
3	Application
2	CAS Registry Number
5	Cloned(Commentary)
101	Disease/ Diagnostics
3	Expression
11	General Information
2	IC50 Value
12	Inhibitors
7	KM Value [mM]
1	Localization
3	Metals/Ions
4	Molecular Weight [Da]
13	Natural Substrates/ Products (Substrates)
2	Organic Solvent Stability
16	Organism
5	pH Optimum
1	pH Stability
1	Posttranslational Modification
2	Purification (Commentary)
2	Reaction
2	Reaction Type
16	Reference
52	Source Tissue
2	Storage Stability
35	Substrates and Products (Substrate)
1	Subunits
23	Synonyms
4	Temperature Optimum [°C]
10	Turnover Number [1/s]

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Cloned on EC 3.4.21.B43 - kallikrein 12

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CLONED (Commentary)

ORGANISM

UNIPROT

LITERATURE

expressed in Escherichia coli strain BL21(DE3)

Homo sapiens

Q9UKR0

682623

expressed in NS0 myeloma cell line

Homo sapiens

-

678534

gene KLK12, formerly KLK5, DNA sequence determination and analysis, chromosome mapping to 19q13.3-13.4, splice variants identification, genomic organization

Homo sapiens

Q9UKR0

647367

molecular cloning of four novel splice variants of the human KLK12 gene, discovered by combining 3' rapid amplification of cDNA ends (3' RACE), NGS technology, advanced bioinformatic analysis, and Sanger sequencing

Homo sapiens

Q9UKR0

752890

the gene is located on chromosome 19q13.4, splice variants KLK12sv3 and KLK12sv1/KLK12sv2 in breast cancer cells by quantitative real-time PCR as well as semi-quantitative PCR expression analysis

Homo sapiens

Q9UKR0

732958