3.4.21.B26: proprotein convertase 5

This is an abbreviated version!
For detailed information about proprotein convertase 5, go to the full flat file.

Reaction

cleavage at the RX(K/R)R consensus motif. Release of mature proteins from their proproteins by cleavage of Arg-Xaa-Yaa-Arg-/-Zaa bonds, where Xaa can be any amino acid and Yaa is Arg or Lys. =

Synonyms

convertase PC5/6, PC5, PC5-A, PC5-B, PC5/6, PC5/6A, PC5/6B, PC5A, PC5B, PC6, PCSK5, prohormone convertase 5, prohormone convertase 5/6, proprotein convertase 5/6, proprotein convertase 5/6A, proprotein convertase PC5/6, proprotein convertase subtilisin/kexin type 5, S08.076, subtilisin/kexin type 5

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.B26 proprotein convertase 5

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Results	in table
2	Activating Compound
3	AA Sequence
8	Application
1	CAS Registry Number
9	Cloned(Commentary)
88	Disease/ Diagnostics
3	Expression
19	General Information
26	Inhibitors
8	Ki Value [mM]
7	KM Value [mM]
16	Localization
2	Metals/Ions
10	Molecular Weight [Da]
10	Natural Substrates/ Products (Substrates)
36	Organism
1	Posttranslational Modification
3	Protein Variants
4	Purification (Commentary)
1	Reaction
6	Reaction Type
36	Reference
118	Source Tissue
37	Substrates and Products (Substrate)
66	Synonyms

Inhibitors

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Inhibitors on EC 3.4.21.B26 - proprotein convertase 5

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

14-dehydroandrographolide succinoyl monoester

Mus musculus

-

syn: SEA, 0.25 mM

649700

alpha1-PDX

Homo sapiens

Q92824

-

680696

-

Alpha1-proteinase inhibitor

Homo sapiens

-

inhibits cleavage of Val-Gln-Arg-Glu-Lys-Arg-Ala-Val-Gly-Leu

673910

-

antitrypsin-Portland

Mus musculus

-

alpha1-antitrypsin-PDX

718009

-

D-Arg-Arg-Arg-Arg-Arg-Arg

Homo sapiens

-

-

682018

D-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg

Homo sapiens

-

-

682018

decanonyl-RVKR-chloromethylketone

Mus musculus

-

-

718009

decanoyl-Arg-Val-Lys-Arg-chloromethylketone

2 entries

hexa-D-arginine

Mus musculus

-

-

718009

L-Arg-Arg-Arg-Arg

Homo sapiens

-

-

682018

L-Arg-Arg-Arg-Arg-Arg

Homo sapiens

-

-

682018

L-Arg-Arg-Arg-Arg-Arg-Arg

Homo sapiens

-

-

682018

L-Arg-Arg-Arg-Arg-Arg-Arg-Arg

Homo sapiens

-

-

682018

L-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg

Homo sapiens

-

-

682018

L-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg

Homo sapiens

-

-

682018

nona-D-arginine

Mus musculus

-

-

718009

PC5-specific antisense oligonucleotide-1

Rattus norvegicus

P41413

inhibits PC activity and consequently av cleavage

673108

PC5-specific antisense oligonucleotide-2

Rattus norvegicus

P41413

inhibits PC activity and consequently av cleavage, most potent inhibitor

673108

prosegment of human furin

Mus musculus

Q04592

-

680190

-

Rapamycin

Rattus norvegicus

P41413

strongly inhibits

675490

transforming growth factor beta-binding protein-2

Mus musculus

-

-

718009

-

transforming growth factor beta-binding protein-3

Mus musculus

-

-

718009

-

additional information

4 entries

-

decanoyl-Arg-Val-Lys-Arg-chloromethylketone

Homo sapiens

Q92824

decreases enzyme activity and expression

731111

decanoyl-Arg-Val-Lys-Arg-chloromethylketone

Rattus norvegicus

P41413

0.05 mM inhibits PC activity and consequently av cleavage

673108

additional information

Homo sapiens

Q92824

PC5-silencing antisense oligonucleotides

675490

-

additional information

Mus musculus

Q04592

PC5 protein expression is reduced in the presence of PC5-1 and PC5-2 pSUPER siRNA vectors

682249

-

additional information

Mus musculus

-

PC5 protein expression is reduced in the presence of PC5-1 and PC5-2 pSUPER siRNA vectors

682249

-

additional information

Rattus norvegicus

P41413

av cleavage not inhibited by the MMP-inhibitor GM6001 and PC5-specific antisense oligonucleotide-3

673108

-