3.4.21.B26: proprotein convertase 5
This is an abbreviated version!
For detailed information about proprotein convertase 5, go to the full flat file.
Word Map on EC 3.4.21.B26
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3.4.21.B26
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furin
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subtilisin-like
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medicine
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endoproteases
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pcsks
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furin-like
- 3.4.21.B26
- furin
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subtilisin-like
- medicine
- endoproteases
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pcsks
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furin-like
Reaction
cleavage at the RX(K/R)R consensus motif. Release of mature proteins from their proproteins by cleavage of Arg-Xaa-Yaa-Arg-/-Zaa bonds, where Xaa can be any amino acid and Yaa is Arg or Lys. =
Synonyms
convertase PC5/6, PC5, PC5-A, PC5-B, PC5/6, PC5/6A, PC5/6B, PC5A, PC5B, PC6, PCSK5, prohormone convertase 5, prohormone convertase 5/6, proprotein convertase 5/6, proprotein convertase 5/6A, proprotein convertase PC5/6, proprotein convertase subtilisin/kexin type 5, S08.076, subtilisin/kexin type 5
ECTree
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Engineering
Engineering on EC 3.4.21.B26 - proprotein convertase 5
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additional information
additional information
stable knockout of the enzyme in HEC-1-A cells by specific siRNA
additional information
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stable knockout of the enzyme in HEC-1-A cells by specific siRNA
additional information
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Pcsk5delta4-deficient allele missing exon 4 that encodes the catalytic Asp173, delta4/delta4 genotype is embryonic lethal, heterozygote mice are healthy and fertile