3.4.21.B26: proprotein convertase 5
This is an abbreviated version!
For detailed information about proprotein convertase 5, go to the full flat file.
Word Map on EC 3.4.21.B26
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3.4.21.B26
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furin
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subtilisin-like
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medicine
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endoproteases
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pcsks
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furin-like
- 3.4.21.B26
- furin
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subtilisin-like
- medicine
- endoproteases
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pcsks
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furin-like
Reaction
cleavage at the RX(K/R)R consensus motif. Release of mature proteins from their proproteins by cleavage of Arg-Xaa-Yaa-Arg-/-Zaa bonds, where Xaa can be any amino acid and Yaa is Arg or Lys. =
Synonyms
convertase PC5/6, PC5, PC5-A, PC5-B, PC5/6, PC5/6A, PC5/6B, PC5A, PC5B, PC6, PCSK5, prohormone convertase 5, prohormone convertase 5/6, proprotein convertase 5/6, proprotein convertase 5/6A, proprotein convertase PC5/6, proprotein convertase subtilisin/kexin type 5, S08.076, subtilisin/kexin type 5
ECTree
3.4.21.B26 proprotein convertase 5Advanced search results
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results (Substrates Products
Substrates Products on EC 3.4.21.B26 - proprotein convertase 5
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-aminobenzoic acid-SKKRKRRFLG-(3-nitro)-Tyr-A + H2O
2-aminobenzoic acid-SKKRKRR + FLG-(3-nitro)-Tyr-A
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fluorogenic substrate encompassing the processing site of envelope glycoproteins of respiratory syncytial virus
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?
2-aminobenzoyl-GGRRTRREAI-(3-nitro)-Tyr-A + H2O
2-aminobenzoyl-GGRRTRR + EAI-(3-nitro)-Tyr-A
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fluorogenic substrate encompassing the processing site of envelope glycoproteins of ebola virus
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?
2-aminobenzoyl-RNTPRERKKRGL-(3-nitro)-Tyr-A + H2O
2-aminobenzoyl-RNTPRERKKR + GL-(3-nitro)-Tyr-A
-
-
-
?
2-aminobenzoyl-RNTPRERRRKKRGL-(3-nitro)-Tyr-A + H2O
2-aminobenzoyl-RNTPRERRRKKR + GL-(3-nitro)-Tyr-A
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fluorogenic substrate encompassing the processing site of envelope glycoproteins of Hong Kong virus
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?
2-aminobenzoyl-RNTPRKKRGL-(3-nitro)-Tyr-A + H2O
2-aminobenzoyl-RNTPRKKR + GL-(3-nitro)-Tyr-A
-
-
-
?
2-aminobenzoyl-RNTPRRRKKRGL-(3-nitro)-Tyr-A + H2O
2-aminobenzoyl-RNTPRRRKKR + GL-(3-nitro)-Tyr-A
-
-
-
?
2-aminobenzoyl-SKKRKRRFLG-(3-nitro)-Tyr-A + H2O
2-aminobenzoyl-SKKRKRR + FLG-(3-nitro)-Tyr-A
-
-
-
-
?
ANKKPPLPKRVRRQIHATPTP + H2O
ANKKPPLPKRVRR + QIHATPTP
a peptide representing alpha-dystroglycan amino acids 299-319 that encompasses the predicted PC6-cleavage site (ANKKPPLPKRVRR312-/-QIHATPTP)
-
-
?
human immunodeficiency virus type 1 Vpr + H2O
?
undergoes proteolytic processing at a very well conserved proprotein convertase cleavage site, R85QRR88-/-, proprotein convertases PC5 and PACE4 can efficiently process extracellular Vpr
-
-
?
PCSK9 + H2O
PCSK9-DELTAN218 + ?
PC5/6A inactivates PCSK9 by cleavage at the motif RFHR218
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-
?
preprohepcidin + H2O
?
key role of the convertases furin, PACE4, PC5 and/or PC7 in the generation and secretion of active hepcidin
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-
?
pro-cocaine- and amphetamine-regulated transcript precursor + H2O
bioactive pro-cocaine- and amphetamine-regulated transcript I + bioactive pro-cocaine- and amphetamine-regulated transcript II + ?
PC5/6A preferentially cleaves the pairs of basic sites, KR/KK, of the CART precursor isoforms
-
-
?
pro-integrin-alpha5 + H2O
active integrin-alpha5 + ?
cleavage of the substrate into its heavy and light chains
-
-
?
pro-integrin-alphaV + H2O
active integrin-alphaV + ?
cleavage of the substrate into its heavy and light chains
-
-
?
proform bone morphogenetic protein-2 + H2O
mature bone morphogenetic protein-2 + ?
-
-
-
?
proform platelet-derived growth factor A + H2O
mature platelet-derived growth factor A + ?
protein tyrosine phosphatase kappa + H2O
?
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the enzyme cleaves the ectodomain of protein tyrosine phosphatase kappa
-
-
?
pyro-ERTKR-7-amido-4-methylcoumarin + H2O
pyro-ERTKR + 7-amino-4-methylcoumarin
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-
-
-
?
pyroglutamic acid-RTKR-7-amido-4-methylcoumarin + H2O
pyroglutamic acid-RTKR + 7-amino-4-methylcoumarin
-
-
-
?
Val-Gln-Arg-Glu-Lys-Arg-Ala-Val-Gly-Leu + H2O
?
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both isoforms are capable of processing the junction between gp120 and gp41 within the HIV-1 gp160 precursor
-
-
?
alpha-dystroglycan + H2O
?
cleavage site (ANKKPPLPKRVRR312-/-QIHATPTP). Full-length alpha-dystroglycan in the human endometrial epithelium is a barrier for embryo attachment and removal of the N-terminus by proprotein convertase 5/6 regulates receptivity. Removal of alpha-dystroglycan N-terminus is an important posttranslational control of endometrial receptivity and uterine fluid
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-
?
alpha-dystroglycan + H2O
?
cleavage site (ANKKPPLPKRVRR312-/-QIHATPTP)
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-
?
osteopontin + H2O
?
Pcsk5/PCSK5 is temporally and spatially expressed with Opn/OPN (Spp1/SPP1) in osteoblasts and osteocytes, indicating that osteopontin could be a physiologically relevant substrate for PC5/6 or PC5/6-activated proteases in bone. Cleavage of osteopontin may modify the function of osteopontin in bone and/or modulate other enzymatic cleavages of osteopontin, leading to alterations in the bone phenotype
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-
?
osteopontin + H2O
?
the enzyme (PC5/6A) efficiently and completely cleaves human osteopontin into three distinct fragments migrating at about 50 kDa, about 18 kDa, and 16 kDa, with evidence for the predicted cleavage sites being at 168RSKSKKFR175-/- and 241KQSR244-/-. PC5/6 also partially cleaves mouse osteopontin to release fragments of about 30 kDa and 29 kDa
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-
?
proform platelet-derived growth factor A + H2O
mature platelet-derived growth factor A + ?
activation
-
-
?
proform platelet-derived growth factor A + H2O
mature platelet-derived growth factor A + ?
activation, the substrate is localized specifically to the apical surface of the luminal and glandular epithelium of uterine endometrium in the receptive phase, but barely detectable in the non-receptive phase
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-
?
additional information
?
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both isoforms can cleave a number of fluorogenic substrates of general formula Arg/Lys-(Xaa)n-(Arg)-, where n= 2, 4, or 6
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-
?
additional information
?
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substrate cleavage analysis. Strong preference of Arg at position P1 and P4
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-
?
additional information
?
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development of a high-throughput immunohistochemic assay for human proprotein convertase 5/6 for detecting uterine receptivity, method evaluation, overview
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?
additional information
?
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development of a high-throughput immunohistochemic assay for human proprotein convertase 5/6 for detecting uterine receptivity, method evaluation, overview
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?
additional information
?
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no substrate: amyloid-beta precursor protein
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?
additional information
?
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death at birth of the PC5/6-deficient embryos
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?
