Application | Comment | Organism |
---|---|---|
medicine | crucial role in heart development and in endothelial cells, involved in embryonic bone morphogenesis | Rattus norvegicus |
medicine | crucial role in prorenin activation within the adrenal cortex or in HIV gp160 processing in CD4+ cells, major impact on cellular proliferation and on sexual differentiation, involvement in food metabolism | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Alpha1-proteinase inhibitor | inhibits cleavage of Val-Gln-Arg-Glu-Lys-Arg-Ala-Val-Gly-Leu | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | PC5-B isoform | Mus musculus | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | 0.2-1 mM required for maximal activity of both isoforms | Mus musculus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
69000 | - |
SDS-PAGE, PC5 of a stable transfectant in AtT-20 cells | Mus musculus |
117000 | - |
SDS-PAGE, PC5-A isoform | Homo sapiens |
117000 | - |
SDS-PAGE, soluble PC5 isolated from the medium of GH4-C1 cells infected with the vaccinia virus recombinant | Rattus norvegicus |
170000 | - |
SDS-PAGE, PC5-B isoform | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
partially purified, DEAE column | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adrenal cortex | - |
Mus musculus | - |
adrenal cortex | - |
Homo sapiens | - |
adrenal cortex | - |
Rattus norvegicus | - |
AtT-20 cell | - |
Mus musculus | - |
brain | - |
Mus musculus | - |
brain | - |
Rattus norvegicus | - |
embryo | - |
Rattus norvegicus | - |
endothelial cell | - |
Mus musculus | - |
endothelial cell | - |
Homo sapiens | - |
endothelial cell | - |
Rattus norvegicus | - |
GH4-C1 cell | - |
Rattus norvegicus | - |
gut | - |
Mus musculus | - |
gut | - |
Rattus norvegicus | - |
additional information | CD4+ cell line | Homo sapiens | - |
Sertoli cell | - |
Mus musculus | - |
Sertoli cell | - |
Rattus norvegicus | - |
testis | - |
Mus musculus | - |
testis | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | both isoforms can cleave a number of fluorogenic substrates of general formula Arg/Lys-(Xaa)n-(Arg)-, where n= 2, 4, or 6 | Homo sapiens | ? | - |
? | |
Val-Gln-Arg-Glu-Lys-Arg-Ala-Val-Gly-Leu + H2O | both isoforms are capable of processing the junction between gp120 and gp41 within the HIV-1 gp160 precursor | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PC5 | - |
Mus musculus |
PC5 | - |
Homo sapiens |
PC5 | - |
Rattus norvegicus |
PC5-A | - |
Mus musculus |
PC5-A | - |
Rattus norvegicus |
PC5-B | - |
Mus musculus |
PC5-B | - |
Rattus norvegicus |
PC5/6 | - |
Mus musculus |
PC5/6 | - |
Rattus norvegicus |
PC6 | - |
Mus musculus |
PC6 | - |
Rattus norvegicus |