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Literature summary for 3.4.21.B26 extracted from

  • Seidah, N.G.; Chretien, M.
    Proprotein convertase 5 (2004), Handbook of Proteolytic Enzymes (Barrett, A. J. , Rawlings, N. D. , Woessner, J. F. , Eds. ) Academic Press, 2, 1874-1877.
No PubMed abstract available

Application

Application Comment Organism
medicine crucial role in heart development and in endothelial cells, involved in embryonic bone morphogenesis Rattus norvegicus
medicine crucial role in prorenin activation within the adrenal cortex or in HIV gp160 processing in CD4+ cells, major impact on cellular proliferation and on sexual differentiation, involvement in food metabolism Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Alpha1-proteinase inhibitor inhibits cleavage of Val-Gln-Arg-Glu-Lys-Arg-Ala-Val-Gly-Leu Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane PC5-B isoform Mus musculus 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ 0.2-1 mM required for maximal activity of both isoforms Mus musculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
69000
-
SDS-PAGE, PC5 of a stable transfectant in AtT-20 cells Mus musculus
117000
-
SDS-PAGE, PC5-A isoform Homo sapiens
117000
-
SDS-PAGE, soluble PC5 isolated from the medium of GH4-C1 cells infected with the vaccinia virus recombinant Rattus norvegicus
170000
-
SDS-PAGE, PC5-B isoform Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partially purified, DEAE column Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
adrenal cortex
-
Mus musculus
-
adrenal cortex
-
Homo sapiens
-
adrenal cortex
-
Rattus norvegicus
-
AtT-20 cell
-
Mus musculus
-
brain
-
Mus musculus
-
brain
-
Rattus norvegicus
-
embryo
-
Rattus norvegicus
-
endothelial cell
-
Mus musculus
-
endothelial cell
-
Homo sapiens
-
endothelial cell
-
Rattus norvegicus
-
GH4-C1 cell
-
Rattus norvegicus
-
gut
-
Mus musculus
-
gut
-
Rattus norvegicus
-
additional information CD4+ cell line Homo sapiens
-
Sertoli cell
-
Mus musculus
-
Sertoli cell
-
Rattus norvegicus
-
testis
-
Mus musculus
-
testis
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information both isoforms can cleave a number of fluorogenic substrates of general formula Arg/Lys-(Xaa)n-(Arg)-, where n= 2, 4, or 6 Homo sapiens ?
-
?
Val-Gln-Arg-Glu-Lys-Arg-Ala-Val-Gly-Leu + H2O both isoforms are capable of processing the junction between gp120 and gp41 within the HIV-1 gp160 precursor Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
PC5
-
Mus musculus
PC5
-
Homo sapiens
PC5
-
Rattus norvegicus
PC5-A
-
Mus musculus
PC5-A
-
Rattus norvegicus
PC5-B
-
Mus musculus
PC5-B
-
Rattus norvegicus
PC5/6
-
Mus musculus
PC5/6
-
Rattus norvegicus
PC6
-
Mus musculus
PC6
-
Rattus norvegicus