3.4.21.B26: proprotein convertase 5
This is an abbreviated version!
For detailed information about proprotein convertase 5, go to the full flat file.
Word Map on EC 3.4.21.B26
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3.4.21.B26
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furin
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subtilisin-like
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medicine
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endoproteases
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pcsks
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furin-like
- 3.4.21.B26
- furin
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subtilisin-like
- medicine
- endoproteases
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pcsks
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furin-like
Reaction
cleavage at the RX(K/R)R consensus motif. Release of mature proteins from their proproteins by cleavage of Arg-Xaa-Yaa-Arg-/-Zaa bonds, where Xaa can be any amino acid and Yaa is Arg or Lys. =
Synonyms
convertase PC5/6, PC5, PC5-A, PC5-B, PC5/6, PC5/6A, PC5/6B, PC5A, PC5B, PC6, PCSK5, prohormone convertase 5, prohormone convertase 5/6, proprotein convertase 5/6, proprotein convertase 5/6A, proprotein convertase PC5/6, proprotein convertase subtilisin/kexin type 5, S08.076, subtilisin/kexin type 5
ECTree
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Application
Application on EC 3.4.21.B26 - proprotein convertase 5
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medicine
av endoproteolytic activation is necessary for integrin-mediated adhesion and migration as well as signaling and requires PC5 in vascular smooth muscle cells
medicine
carotid atherosclerotic lesions obtained by endaterectomy contain PC5, PC5 colocalizes with av integrin
medicine
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crucial role in heart development and in endothelial cells, involved in embryonic bone morphogenesis
medicine
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crucial role in prorenin activation within the adrenal cortex or in HIV gp160 processing in CD4+ cells, major impact on cellular proliferation and on sexual differentiation, involvement in food metabolism
medicine
PC5 is a potential contributor to the initiation, progression, and complications of atherosclerosis and restenosis, targeting PC5 will likely provide novel anti-atherosclerosis strategies
medicine
PC5 is a potential contributor to the initiation, progression, and complications of atherosclerosis and restenosis, targeting PC5 will likely provide novel anti-atherosclerosis strategies
medicine
PC5/6 plays a key role for decidualization in human endometrium and its action is necessary for prolactin production from endometrial stromal cells
medicine
PC5/6A is involved in squamous differentiation of human nasal epithelial cells, possibly through up-regulation of the BMP-2/pSmad1/5/8/p38 signaling pathway, pointing to a potential therapeutic target for the prevention of chronic airway diseases that exhibit squamous metaplasia