3.4.21.B24: proprotein convertase 4

This is an abbreviated version!
For detailed information about proprotein convertase 4, go to the full flat file.

Reaction

cleaves hormones at pairs of basic amino acid residues =

Synonyms

More, PC4, PC4A, PCSK4, proprotein convertase 4, proprotein convertase PC4, proprotein convertase PC4/PCSK4, proprotein convertase subtilisin/kexin type 4, proprotein convertase subtilisin/kexin-like 4, S08.074

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.B24 proprotein convertase 4

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Results	in table
2	Activating Compound
3	AA Sequence
5	Application
1	CAS Registry Number
9	Cloned(Commentary)
12	Disease/ Diagnostics
11	General Information
2	IC50 Value
21	Inhibitors
7	Ki Value [mM]
2	KM Value [mM]
10	Localization
2	Metals/Ions
7	Molecular Weight [Da]
10	Natural Substrates/ Products (Substrates)
22	Organism
1	pH Optimum
7	Posttranslational Modification
2	Protein Variants
1	Purification (Commentary)
1	Reaction
8	Reaction Type
21	Reference
48	Source Tissue
41	Substrates and Products (Substrate)
8	Subunits
42	Synonyms

Disease

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Disease on EC 3.4.21.B24 - proprotein convertase 4

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DISEASE

TITLE OF PUBLICATION

LINK TO PUBMED

Hepatitis B

Synthetic bacterial lipopeptide analogs facilitate naive CD4+ T cell differentiation and enhance antigen-specific HLA-II-restricted responses.

16052608

Herpes Zoster

Sperm from mice genetically deficient for the PCSK4 proteinase exhibit accelerated capacitation, precocious acrosome reaction, reduced binding to egg zona pellucida, and impaired fertilizing ability.

16371590

Hypoglycemia

Imbalanced Expression of IGF2 and PCSK4 Is Associated With Overproduction of Big IGF2 in SFT With NICTH: A Pilot Study.

29897468

Infertility

Proprotein convertase subtilisin/kexin type 4 in mammalian fertility: a review.

19109312

Tetanus

Synthetic bacterial lipopeptide analogs facilitate naive CD4+ T cell differentiation and enhance antigen-specific HLA-II-restricted responses.

16052608

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