3.4.21.B24: proprotein convertase 4
This is an abbreviated version!
For detailed information about proprotein convertase 4, go to the full flat file.
Word Map on EC 3.4.21.B24
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3.4.21.B24
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testicular
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sperm
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acrosome
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medicine
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furin
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sperm-egg
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pellucida
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subtilases
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endoproteinase
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zona
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spermatogenic
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burgdorferi
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borrelia
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egg-binding
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subfertility
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intramolecularly
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prodomain
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pacap
- 3.4.21.B24
- testicular
- sperm
-
acrosome
- medicine
- furin
-
sperm-egg
- pellucida
-
subtilases
-
endoproteinase
- zona
-
spermatogenic
- burgdorferi
-
borrelia
-
egg-binding
- subfertility
-
intramolecularly
- prodomain
-
pacap
Reaction
cleaves hormones at pairs of basic amino acid residues =
Synonyms
More, PC4, PC4A, PCSK4, proprotein convertase 4, proprotein convertase PC4, proprotein convertase PC4/PCSK4, proprotein convertase subtilisin/kexin type 4, proprotein convertase subtilisin/kexin-like 4, S08.074
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Subunits
Subunits on EC 3.4.21.B24 - proprotein convertase 4
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additional information
PCSKs are biosynthesized in the endoplasmic reticulum as multidomain preproproteins consisting of an N-terminal signal peptide followed by a pro domain, a conserved catalytic domain, a P domain, and a variable C-terminal domain. After cotranslational removal of the signal peptide, the resulting proPCSK undergoes maturation by autocatalytic cleavage between the pro and the catalytic domains, within a cleavage motif that is also recognized by the fully activated enzyme in the primary sequence of its physiological substrates. Domain structure, overview
additional information
-
PCSKs are biosynthesized in the endoplasmic reticulum as multidomain preproproteins consisting of an N-terminal signal peptide followed by a pro domain, a conserved catalytic domain, a P domain, and a variable C-terminal domain. After cotranslational removal of the signal peptide, the resulting proPCSK undergoes maturation by autocatalytic cleavage between the pro and the catalytic domains, within a cleavage motif that is also recognized by the fully activated enzyme in the primary sequence of its physiological substrates. Domain structure, overview
additional information
PCSKs are biosynthesized in the endoplasmic reticulum as multidomain preproproteins consisting of an N-terminal signal peptide followed by a pro domain, a conserved catalytic domain, a P domain, and a variable C-terminal domain. After cotranslational removal of the signal peptide, the resulting proPCSK undergoes maturation by autocatalytic cleavage between the pro and the catalytic domains, within a cleavage motif that is also recognized by the fully activated enzyme in the primary sequence of its physiological substrates
additional information
-
PCSKs are biosynthesized in the endoplasmic reticulum as multidomain preproproteins consisting of an N-terminal signal peptide followed by a pro domain, a conserved catalytic domain, a P domain, and a variable C-terminal domain. After cotranslational removal of the signal peptide, the resulting proPCSK undergoes maturation by autocatalytic cleavage between the pro and the catalytic domains, within a cleavage motif that is also recognized by the fully activated enzyme in the primary sequence of its physiological substrates