3.4.21.B24: proprotein convertase 4
This is an abbreviated version!
For detailed information about proprotein convertase 4, go to the full flat file.
Word Map on EC 3.4.21.B24
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3.4.21.B24
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testicular
-
sperm
-
acrosome
-
medicine
-
furin
-
sperm-egg
-
pellucida
-
subtilases
-
endoproteinase
-
zona
-
spermatogenic
-
burgdorferi
-
borrelia
-
egg-binding
-
subfertility
-
intramolecularly
-
prodomain
-
pacap
- 3.4.21.B24
- testicular
- sperm
-
acrosome
- medicine
- furin
-
sperm-egg
- pellucida
-
subtilases
-
endoproteinase
- zona
-
spermatogenic
- burgdorferi
-
borrelia
-
egg-binding
- subfertility
-
intramolecularly
- prodomain
-
pacap
Reaction
cleaves hormones at pairs of basic amino acid residues =
Synonyms
More, PC4, PC4A, PCSK4, proprotein convertase 4, proprotein convertase PC4, proprotein convertase PC4/PCSK4, proprotein convertase subtilisin/kexin type 4, proprotein convertase subtilisin/kexin-like 4, S08.074
ECTree
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Reference on EC 3.4.21.B24 - proprotein convertase 4
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Seidah, N.G.; Chretien, M.
Pro-protein convertases of subtilisin/kexin family
Methods Enzymol.
244
175-188
1994
Mammalia, Rattus norvegicus
Basak, A.; Toure, B.B.; Lazure, C.; Mbikay, M.; Chretien, M.; Seidah, N.G.
Enzymic characterization in vitro of recombinant proprotein convertase PC4
Biochem. J.
343
29-37
1999
Rattus norvegicus
De Strooper, B.; Creemers, J.W.; Moechars, D.; Huylebroeck, D.; Van De Ven, W.J.; Van Leuven, F.; Van den Berghe, H.
Amyloid precursor protein is not processed by furin, PACE 4, PC1/3, PC2, PC4 and PC5/6 of the furin family of proprotein processing enzymes
Biochim. Biophys. Acta
1246
185-188
1995
Mus musculus
Basak, S.; Chretien, M.; Mbikay, M.; Basak, A.
In vitro elucidation of substrate specificity and bioassay of proprotein convertase 4 using intramolecularly quenched fluorogenic peptides
Biochem. J.
380
505-514
2004
Mus musculus, Rattus norvegicus
Bassi, D.E.; Fu, J.; Lopez de Cicco, R.; Klein-Szanto, A.J.
Proprotein convertases: "master switches" in the regulation of tumor growth and progression
Mol. Carcinog.
44
151-161
2005
Homo sapiens
Qiu, Q.; Basak, A.; Mbikay, M.; Tsang, B.K.; Gruslin, A.
Role of pro-IGF-II processing by proprotein convertase 4 in human placental development
Proc. Natl. Acad. Sci. USA
102
11047-11052
2005
Homo sapiens (Q6UW60), Homo sapiens
Gyamera-Acheampong, C.; Tantibhedhyangkul, J.; Weerachatyanukul, W.; Tadros, H.; Xu, H.; van de Loo, J.; Pelletier, R.; Tanphaichitr, N.; Mbikay, M.
Sperm from mice genetically deficient for the PCSK4 proteinase exhibit accelerated capacitation, precocious acrosome reaction, reduced binding to egg zona pellucida, and impaired fertilizing ability
Biol. Reprod.
74
666-673
2006
Mus musculus (P29121), Mus musculus
Freyer, C.; Kilpatrick, L.M.; Salamonsen, L.A.; Nie, G.
Pro-protein convertases (PCs) other than PC6 are not tightly regulated for implantation in the human endometrium
Reproduction
133
1189-1197
2007
Homo sapiens (Q6UW60)
Gyamera-Acheampong, C.; Mbikay, M.
Proprotein convertase subtilisin/kexin type 4 in mammalian fertility: a review.
Hum. Reprod. Update
15
237-247
2009
Mus musculus (P29121), Mus musculus, Homo sapiens (Q6UW60), Homo sapiens
Basak, A.; Shervani, N.J.; Mbikay, M.; Kolajova, M.
Recombinant proprotein convertase 4 (PC4) from Leishmania tarentolae expression system: purification, biochemical study and inhibitor design
Protein Expr. Purif.
60
117-126
2008
Rattus norvegicus
Basak, A.; Shervani, N.; Kolajova, M.; Cherla, S.; Basak, S.
Novel reactive site loop derived mini-serpin inhibitors of recombinant proprotein convertase 4
Adv. Exp. Med. Biol.
611
105-106
2009
Mammalia
Gyamera-Acheampong, C.; Sirois, F.; Denis, N.J.; Mishra, P.; Figeys, D.; Basak, A.; Mbikay, M.
The precursor to the germ cell-specific PCSK4 proteinase is inefficiently activated in transfected somatic cells: evidence of interaction with the BiP chaperone
Mol. Cell. Biochem.
348
43-52
2011
Mus musculus, Rattus norvegicus, Homo sapiens (Q6UW60), Homo sapiens
Mishra, P.; Qiu, Q.; Gruslin, A.; Hidaka, Y.; Mbikay, M.; Basak, A.
In vitro regulatory effect of epididymal serpin CRES on protease activity of proprotein convertase PC4/PCSK4
Curr. Mol. Med.
12
1050-1067
2012
Mus musculus (P29121), Homo sapiens (Q6KW60), Homo sapiens
Tardif, S.; Guyonnet, B.; Cormier, N.; Cornwall, G.A.
Alteration in the processing of the ACRBP/sp32 protein and sperm head/acrosome malformations in proprotein convertase 4 (PCSK4) null mice
Mol. Hum. Reprod.
18
298-307
2012
Mus musculus (P29121)
Basak, A.; Goswami, M.; Rajkumar, A.; Mitra, T.; Majumdar, S.; OReilly, P.; Bdour, H.M.; Trudeau, V.L.; Basak, A.
Enediynyl peptides and iso-coumarinyl methyl sulfones as inhibitors of proprotein convertases PCSK8/SKI-1/S1P and PCSK4/PC4 Design, synthesis and biological evaluations
Bioorg. Med. Chem. Lett.
25
2225-2237
2015
Rattus norvegicus (Q78EH2)
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