3.4.21.B24: proprotein convertase 4

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For detailed information about proprotein convertase 4, go to the full flat file.

Reaction

cleaves hormones at pairs of basic amino acid residues =

Synonyms

More, PC4, PC4A, PCSK4, proprotein convertase 4, proprotein convertase PC4, proprotein convertase PC4/PCSK4, proprotein convertase subtilisin/kexin type 4, proprotein convertase subtilisin/kexin-like 4, S08.074

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.B24 proprotein convertase 4

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Results	in table
2	Activating Compound
3	AA Sequence
5	Application
1	CAS Registry Number
9	Cloned(Commentary)
12	Disease/ Diagnostics
11	General Information
2	IC50 Value
21	Inhibitors
7	Ki Value [mM]
2	KM Value [mM]
10	Localization
2	Metals/Ions
7	Molecular Weight [Da]
10	Natural Substrates/ Products (Substrates)
22	Organism
1	pH Optimum
7	Posttranslational Modification
2	Protein Variants
1	Purification (Commentary)
1	Reaction
8	Reaction Type
21	Reference
48	Source Tissue
41	Substrates and Products (Substrate)
8	Subunits
42	Synonyms

Activating Compound

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Activating Compound on EC 3.4.21.B24 - proprotein convertase 4

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ACTIVATING COMPOUND

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

dithiothreitol

Rattus norvegicus

-

2.5fold activation at 1 mM

649673

prodomain rPC4101-116 peptide

Rattus norvegicus

-

at concentrations below 0.001 mM, it enhances PC4-activity depending on concentration (by as much as about 2fold). This activation effect is less significant for a higher substrate concentration and is not noticeable at concentrations above 0.02 mM

694967

-