3.4.21.B24: proprotein convertase 4
This is an abbreviated version!
For detailed information about proprotein convertase 4, go to the full flat file.
Word Map on EC 3.4.21.B24
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3.4.21.B24
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testicular
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sperm
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acrosome
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medicine
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furin
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sperm-egg
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pellucida
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subtilases
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endoproteinase
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zona
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spermatogenic
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burgdorferi
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borrelia
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egg-binding
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subfertility
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intramolecularly
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prodomain
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pacap
- 3.4.21.B24
- testicular
- sperm
-
acrosome
- medicine
- furin
-
sperm-egg
- pellucida
-
subtilases
-
endoproteinase
- zona
-
spermatogenic
- burgdorferi
-
borrelia
-
egg-binding
- subfertility
-
intramolecularly
- prodomain
-
pacap
Reaction
cleaves hormones at pairs of basic amino acid residues =
Synonyms
More, PC4, PC4A, PCSK4, proprotein convertase 4, proprotein convertase PC4, proprotein convertase PC4/PCSK4, proprotein convertase subtilisin/kexin type 4, proprotein convertase subtilisin/kexin-like 4, S08.074
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General Information
General Information on EC 3.4.21.B24 - proprotein convertase 4
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evolution
malfunction
physiological function
proprotein convertase 4 is a member of a family of proprotein convertases that convert inactive precursor proteins into their mature and active forms
evolution
the enzyme belongs to the 9-member superfamily of mammalian subtilases collectively called proprotein convertases or proprotein convertase subtilisin/kexins that convert inactive precursor proteins into their active mature forms by endoproteolytic cleavage
evolution
Q6KW60
the enzyme belongs to the 9-member superfamily of mammalian subtilases collectively called proprotein convertases or proprotein convertase subtilisin/kexins that convert inactive precursor proteins into their active mature forms by endoproteolytic cleavage
inactivation of its gene in mouse does not alter spermatogenesis, but renders sperm incapable of fertilizing oocytes, resulting in part from sperm susceptibility to a premature acrosome reaction and from reduced ability to bind to the zona pellucida. In female mice, a lack of PCSK4 causes subfertility associated with impaired folliculogenesis
malfunction
PC4 knockout mice exhibit severely impaired male fertility due to premature sperm acrosome reaction
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PC4 activates everal protein precursors in the secretory pathway of mammalian reproduction system with a vital role in fertilization and sperm maturation
physiological function
the enzyme belongs to a family of endoproteinases involved in the proteolytic conversion of secretory precursor proteins to their active forms. PCSK4 appears to be a crucial enzyme for reproduction
physiological function
the enzyme belongs to a family of endoproteinases involved in the proteolytic conversion of secretory precursor proteins to their active forms. PCSK4 appears to be a crucial enzyme for reproduction. It stimulates the invasiveness of human placental trophoblasts in culture, suggesting that it may facilitate placentation in vivo
physiological function
the enzyme activity plays a crucial role in mammalian fertilization via activation of sperm surface proteins
physiological function
Q6KW60
the enzyme activity plays a crucial role in mammalian fertilization via activation of sperm surface proteins
physiological function
the enzyme is linked to mammalian fertilization and placenta growth