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3.4.21.115: infectious pancreatic necrosis birnavirus Vp4 peptidase

This is an abbreviated version!
For detailed information about infectious pancreatic necrosis birnavirus Vp4 peptidase, go to the full flat file.

Word Map on EC 3.4.21.115

Reaction

cleaves the (Ser/Thr)-Xaa-Ala-/-(Ser/Ala)-Gly motif in the polyprotein NH2-pVP2-VP4-VP3-COOH of infectious pancreatic necrosis virus at the pVP2-VP4 and VP4-VP3 junctions =

Synonyms

avian infectious busrsal disease birnavirus Vp4 endopeptidase, blotched snakehead birnavirus endopeptidase, Drosophila X virus Vp4 protease, equine arterivirus serine peptidase, infectious pancreatic necrosis birnavirus Vp4 protease, NS, NS protease, S50.001, VP4

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.115 infectious pancreatic necrosis birnavirus Vp4 peptidase

Substrates Products

Substrates Products on EC 3.4.21.115 - infectious pancreatic necrosis birnavirus Vp4 peptidase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
NH2-pVP2-X-VP4-VP3-COOH + H2O
pVP2 + peptide X + VP4 + VP3
show the reaction diagram
VP4 is encoded as part of the 1114-residue long segment A polyprotein NH2-pVP2-X-VP4-VP3-COOH. It cleaves after amino acid residue positions 512, 618, and 830 to yield capsid precursor protein pVP2, peptide X, VP4 itself, and ribonucleoprotein VP3. Additional cleavage sites were found at the C-terminal side of amino acids 451, 492, and 499 within the pVP2 region
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-
?
polyprotein of BSNV + H2O
pVP2 + VP3 + VP4
show the reaction diagram
polyprotein of IPNV + H2O
pVP2 + VP3 + VP4
show the reaction diagram
additional information
?
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