3.4.21.115: infectious pancreatic necrosis birnavirus Vp4 peptidase

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For detailed information about infectious pancreatic necrosis birnavirus Vp4 peptidase, go to the full flat file.

Word Map on EC 3.4.21.115

3.4.21.115

polyprotein

rubella

nonstructural

lamins

replicase

papain-like

baculoviruses

ca2+-regulated

replicons

catalytic-site

multicatalytic

zn2+-binding

virol

nucleocytoplasmic

alphaviruses

self-cleavage

minidomain

Reaction

cleaves the (Ser/Thr)-Xaa-Ala-/-(Ser/Ala)-Gly motif in the polyprotein NH2-pVP2-VP4-VP3-COOH of infectious pancreatic necrosis virus at the pVP2-VP4 and VP4-VP3 junctions =

Synonyms

avian infectious busrsal disease birnavirus Vp4 endopeptidase, blotched snakehead birnavirus endopeptidase, Drosophila X virus Vp4 protease, equine arterivirus serine peptidase, infectious pancreatic necrosis birnavirus Vp4 protease, NS, NS protease, S50.001, VP4

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.21 Serine endopeptidases

3.4.21.115 infectious pancreatic necrosis birnavirus Vp4 peptidase

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Results	in table
4	AA Sequence
1	CAS Registry Number
7	Cloned(Commentary)
4	Crystallization (Commentary)
6	Molecular Weight [Da]
7	Natural Substrates/ Products (Substrates)
11	Organism
8	PDB ID
1	pI Value
3	Posttranslational Modification
22	Protein Variants
7	Purification (Commentary)
1	Reaction
9	Reaction Type
11	Reference
4	Source Tissue
1	Specific Activity [micromol/min/mg]
11	Substrates and Products (Substrate)
1	Subunits
18	Synonyms

Crystallization

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Crystallization on EC 3.4.21.115 - infectious pancreatic necrosis birnavirus Vp4 peptidase

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a truncated variant with 18 residues removed from the C-terminal

2 entries

two crystal structures of the IPNV VP4 protease solved from two different crystal symmetries, refinement to 2.2 A resolution reveals the acyl-enzyme complex formed with an internal VP4 cleavage site, substrate binding pockets S1, S3, S5, and S6 identified, conserved overall structure of VP4 determined by three-dimensional alignments

infectious pancreatic necrosis virus

Q703G9

683650

VP4 with the C-terminus binding into its own active site forming an intramolecular (cis) acyl-enzyme complex, hanging drop vapor diffusion method, using 21% (w/v) PEG8000 and 0.55 M ammonium sulfate

Tellina virus 1

Q2PBR5

717819