3.4.19.6: pyroglutamyl-peptidase II

This is an abbreviated version!
For detailed information about pyroglutamyl-peptidase II, go to the full flat file.

Word Map on EC 3.4.19.6

3.4.19.6

pituitary

adenohypophyseal

hypothalamic

adenohypophysis

tsh

paraventricular

ectopeptidase

lactotrophs

trh-r1

trhergic

eminence

tanycytes

deiodinase

hypothalamus-pituitary-thyroid

peptidergic

trh-receptor

mediobasal

hypophysiotropic

trh-induced

medicine

trh-like

nutrition

Reaction

release of the N-terminal pyroglutamyl group from pGlu-/-His-Xaa tripeptides and pGlu-/-His-Xaa-Gly tetrapeptides =

Synonyms

aminopeptidase, thyrotropin-releasing factor pyroglutamate, PAP type II, PPII, pyroglutamate aminopeptidase II, pyroglutamyl aminopeptidase II, pyroglutamyl peptidase II, pyrrolidone carboxypeptidase type II, thyroliberin-hydrolyzing pyroglutamate aminopeptidase, thyroliberinase, thyrotropin-releasing hormone-degrading peptidase, thyrotropin-releasing hormone-degrading pyroglutamate aminopeptidase, TRH aminopeptidase, TRH-DE, TRH-degrading ectoenzyme, TRH-degrading enzyme, TRH-specific aminopeptidase

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.19 Omega peptidases

3.4.19.6 pyroglutamyl-peptidase II

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Results	in table
4	Activating Compound
11	AA Sequence
5	Application
1	CAS Registry Number
2	Cloned(Commentary)
7	General Information
8	General Stability
126	Inhibitors
77	Ki Value [mM]
23	KM Value [mM]
20	Localization
6	Metals/Ions
12	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
37	Organism
4	pH Optimum
2	pH Range
1	pH Stability
4	Posttranslational Modification
13	Protein Variants
8	Purification (Commentary)
1	Reaction
5	Reaction Type
37	Reference
66	Source Tissue
5	Specific Activity [micromol/min/mg]
4	Storage Stability
64	Substrates and Products (Substrate)
7	Subunits
36	Synonyms
3	Temperature Optimum [°C]
2	Temperature Range [°C]
6	Temperature Stability [°C]
2	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 3.4.19.6 - pyroglutamyl-peptidase II

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thyroliberin + H2O

3 entries

thyrotrophin-releasing hormone + H2O

L-pyroglutamate + ?

Mus musculus

Q9UKU6

753360

thyrotropin releasing hormone + H2O

Rattus norvegicus

700461, 700583

TRH-like peptide + H2O

L-pyroglutamate + ?

Mus musculus

Q9UKU6

753360

additional information

Rattus norvegicus

detection of a RNA species derived from an alternative processing at the exon 14intron 14 boundary. The alternatively processed RNA encodes a shorter version of PPII (PPII*), lacking part of the C-terminal domain. PPII* is expressed in COS-7 (or C6 glioma) cells but it does not exhibit any PPII activity. Co-transfection of PPII and increasing amounts of PPII* expression vectors results in a dose-dependent reduction in PPII activity and the formation of covalent PPIIPPII* heterodimers. PPII* is therefore a powerful dominant-negative isoform of PPII, and heterodimerization may be its mechanism of action. Natural expression of shortened versions of M1 aminopeptidases may constitute a new mode of regulation of their activity

669931