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3.4.19.6: pyroglutamyl-peptidase II

This is an abbreviated version!
For detailed information about pyroglutamyl-peptidase II, go to the full flat file.

Word Map on EC 3.4.19.6

Reaction

release of the N-terminal pyroglutamyl group from pGlu-/-His-Xaa tripeptides and pGlu-/-His-Xaa-Gly tetrapeptides =

Synonyms

aminopeptidase, thyrotropin-releasing factor pyroglutamate, PAP type II, PPII, pyroglutamate aminopeptidase II, pyroglutamyl aminopeptidase II, pyroglutamyl peptidase II, pyrrolidone carboxypeptidase type II, thyroliberin-hydrolyzing pyroglutamate aminopeptidase, thyroliberinase, thyrotropin-releasing hormone-degrading peptidase, thyrotropin-releasing hormone-degrading pyroglutamate aminopeptidase, TRH aminopeptidase, TRH-DE, TRH-degrading ectoenzyme, TRH-degrading enzyme, TRH-specific aminopeptidase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.19 Omega peptidases
                3.4.19.6 pyroglutamyl-peptidase II

Storage Stability

Storage Stability on EC 3.4.19.6 - pyroglutamyl-peptidase II

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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-20°C, potassium phosphate buffer, pH 7.4, stable for 6 months
-
15°C, 5% loss of activity after 7 days
-
4°C or -20°C, 24 h, decrease of more than 50% of activity of the enzyme solubilized by sodium deoxycholate or Triton X-100, the CHAPS solubilized enzyme is slightly more stable with approximately 90% and 40% of the activity remaining after 72 h at 4°C and -20°C
-
stable at 4°C for more than 2 months or for 24 h at 25°C, in phosphate or diethylmalonate buffer, pH 7.3, irrespective of the protein concentration
-