3.4.19.6: pyroglutamyl-peptidase II
This is an abbreviated version!
For detailed information about pyroglutamyl-peptidase II, go to the full flat file.
Word Map on EC 3.4.19.6
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3.4.19.6
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pituitary
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adenohypophyseal
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hypothalamic
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adenohypophysis
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tsh
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paraventricular
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ectopeptidase
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lactotrophs
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trh-r1
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trhergic
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eminence
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tanycytes
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deiodinase
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hypothalamus-pituitary-thyroid
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peptidergic
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trh-receptor
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mediobasal
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hypophysiotropic
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trh-induced
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medicine
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trh-like
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nutrition
- 3.4.19.6
- pituitary
- adenohypophyseal
- hypothalamic
- adenohypophysis
- tsh
-
paraventricular
-
ectopeptidase
-
lactotrophs
-
trh-r1
-
trhergic
-
eminence
- tanycytes
-
deiodinase
-
hypothalamus-pituitary-thyroid
-
peptidergic
-
trh-receptor
-
mediobasal
-
hypophysiotropic
-
trh-induced
- medicine
-
trh-like
- nutrition
Reaction
release of the N-terminal pyroglutamyl group from pGlu-/-His-Xaa tripeptides and pGlu-/-His-Xaa-Gly tetrapeptides =
Synonyms
aminopeptidase, thyrotropin-releasing factor pyroglutamate, PAP type II, PPII, pyroglutamate aminopeptidase II, pyroglutamyl aminopeptidase II, pyroglutamyl peptidase II, pyrrolidone carboxypeptidase type II, thyroliberin-hydrolyzing pyroglutamate aminopeptidase, thyroliberinase, thyrotropin-releasing hormone-degrading peptidase, thyrotropin-releasing hormone-degrading pyroglutamate aminopeptidase, TRH aminopeptidase, TRH-DE, TRH-degrading ectoenzyme, TRH-degrading enzyme, TRH-specific aminopeptidase
ECTree
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Source Tissue
Source Tissue on EC 3.4.19.6 - pyroglutamyl-peptidase II
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orchidectomy increases activity of pyrrolidone carboxypeptidase type II, testosterone replacement returns it to control levels
12 to 14% of cell profiles express pyroglutamyl peptidase II mRNA in the medial septum-diagonal band of Broca, in this region the specific activity of the enzyme is relatively high. Injection of the pyroglutamyl peptidase II inhibitor p-Glu-Asn-Pro-7-amido-4-methylcoumarin into the medial septum enhances the effect of thyrotropin-releasing hormone. The injection of a phosphinic thyrotropin-releasing hormone analog, a higher affinity inhibitor of pyroglutamyl peptidase II, diminishes the duration of ethanol-induced loss of righting reflex by itself
additional information
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expression of wild-type and mutant enzymes in COS-7 cells and C6 glioma
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changes in enzyme activity caused by kindling relate to regulation of the expression of TRH receptors and degrading enzyme
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no change in pyrrolidone carboxypeptidase type II after orchidectomy, activity increases after administration of testosterone