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3.4.19.6: pyroglutamyl-peptidase II

This is an abbreviated version!
For detailed information about pyroglutamyl-peptidase II, go to the full flat file.

Word Map on EC 3.4.19.6

Reaction

release of the N-terminal pyroglutamyl group from pGlu-/-His-Xaa tripeptides and pGlu-/-His-Xaa-Gly tetrapeptides =

Synonyms

aminopeptidase, thyrotropin-releasing factor pyroglutamate, PAP type II, PPII, pyroglutamate aminopeptidase II, pyroglutamyl aminopeptidase II, pyroglutamyl peptidase II, pyrrolidone carboxypeptidase type II, thyroliberin-hydrolyzing pyroglutamate aminopeptidase, thyroliberinase, thyrotropin-releasing hormone-degrading peptidase, thyrotropin-releasing hormone-degrading pyroglutamate aminopeptidase, TRH aminopeptidase, TRH-DE, TRH-degrading ectoenzyme, TRH-degrading enzyme, TRH-specific aminopeptidase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.19 Omega peptidases
                3.4.19.6 pyroglutamyl-peptidase II

KI Value

KI Value on EC 3.4.19.6 - pyroglutamyl-peptidase II

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00124
1,3-benzodioxol-5-amine
-
-
0.02187
2-Aminobenzyl alcohol
-
-
0.00742
2-hydroxyaniline
-
-
0.00398
2-Phenylethylamine
-
-
0.00318
3,4-dimethoxyaniline
-
-
0.00085
3,5-dimethoxyaniline
-
-
0.00125
3-(trifluoromethoxy)aniline
-
-
0.00498
3-phenyl-1-propylamine
-
-
0.00097
4-(trifluoromethyl)aniline
-
-
0.0089
4-amino-N-methylphthalamide
-
-
0.00345
4-phenylbutylamine
-
-
0.01014
5,6,7,8-tetrahydro-1-naphthylamine
-
-
0.00163
5-amino-2-chloropyridine
-
-
0.00254
5-amino-2-methoxyphenol
-
-
0.00084
5-aminoindan
-
-
0.01085
5-chloro-2-methoxyaniline
-
-
0.00278
6-amino-1,3-dihydroisobenzofuran-1-one
-
-
0.00362
6-amino-2-mercaptobenzothiazole
-
-
0.0019
6-amino-3,4-benzocoumarin
-
-
0.000047
7-amino-4-methylcoumarin
-
-
0.0028
aniline
-
-
0.01529
benzyl alcohol
-
-
0.01281
benzylamine
-
-
0.000096
Glp-Asn-Pro-D-Tyr-D-Trp-7-amido-4-methyl-coumarin
-
-
0.000029
Glp-Asn-Pro-D-Tyr-D-Trp-D-Trp-7-amido-4-methyl-coumarin
-
-
0.000151
Glp-Asn-Pro-D-Tyr-D-TrpNH2
-
-
0.000038
Glp-Asn-Pro-Tyr-Trp-7-amido-4-methyl-coumarin
-
-
0.000001
Glp-Asn-Pro-Tyr-Trp-Trp-7-amido-4-methyl-coumarin
-
-
0.00064
Glp-Asn-Pro-Tyr-TrpNH2
-
-
0.000051
Hermodice carunculata inhibitor
-
37°C
-
0.008
Luteinizing hormone releasing hormone
-
-
0.00127
m-anisidine
-
-
0.00167
m-phenethidine
-
-
0.08416
methyl alcohol
-
-
0.01084
methylamine
-
-
0.01263
o-anisidine
-
-
0.00407
p-anisidine
-
-
0.0996
pyroglutamyl-Asn(N-benzyl)-ProNH2
-
37°C, pH 7.5
0.115
pyroglutamyl-Asn(N-hydroxyl)-ProNH2
-
37°C, pH 7.5
0.103
pyroglutamyl-Asn(N-methyl)-ProNH2
-
37°C, pH 7.5
0.133
pyroglutamyl-Asn(N-phenyl)-ProNH2
-
37°C, pH 7.5
0.00097
pyroglutamyl-Asn-Pro-7-amido-4-methyl coumarin
-
pH 7.5, 37°C, hydrolysis of pyroglutamyl-His-Pro-7-amido-4-methylcoumarin
0.000458
pyroglutamyl-Asn-Pro-7-amido-4-methylcoumarin
-
-
0.0175
pyroglutamyl-Asn-Pro-NH2
-
pH 7.5, 37°C, hydrolysis of pyroglutamyl-His-Pro-7-amido-4-methylcoumarin
0.00811
pyroglutamyl-Asn-Pro-Ser-TyrNH2
-
-
0.000083
pyroglutamyl-Asn-Pro-Trp-7-amido-4-methylcoumarin
-
-
0.000072
pyroglutamyl-Asn-Pro-Trp-Trp-7-amido-4-methylcoumarin
-
-
0.00591
pyroglutamyl-Asn-Pro-Trp-TyrNH2
-
-
0.00517
pyroglutamyl-Asn-Pro-TrpNH2
-
-
0.000038
pyroglutamyl-Asn-Pro-Tyr-Trp-7-amido-4-methylcoumarin
-
-
0.000001
pyroglutamyl-Asn-Pro-Tyr-Trp-Trp-7-amido-4-methylcoumarin
-
-
0.000734
pyroglutamyl-Asn-Pro-Tyr-Trp-TrpNH2
-
-
0.000639
pyroglutamyl-Asn-Pro-Tyr-TrpNH2
-
-
0.0103
pyroglutamyl-Asn-Pro-TyrNH2
-
-
0.0161
pyroglutamyl-Asn-ProNH2
0.069
pyroglutamyl-Gln-Pro-NH2
-
pH 7.5, 37°C, hydrolysis of pyroglutamyl-His-Pro-7-amido-4-methylcoumarin
1.67
Pyroglutamyl-His-Gly
-
37°C
0.582
pyroglutamyl-His-Gly-NH2
-
37°C
0.236
pyroglutamyl-His-Pro
-
37°C
0.0588
pyroglutamyl-His-Pro-Gly
-
37°C
0.0296
pyroglutamyl-His-Pro-Gly-NH2
-
37°C
0.0403
pyroglutamyl-His-Pro-NH2
-
37°C
0.0081
pyroglutamyl-His-Trp-Ser-Tyr-Gly
-
37°C
0.0194
pyroglutamyl-His-Trp-Ser-Tyr-Gly-Leu
-
37°C
0.0603
pyroglutamyl-His-Trp-Ser-Tyr-Gly-Leu-Arg
-
37°C
0.0108
pyroglutamyl-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly
-
37°C
0.5
pyroglutamyl-homoprolyl-Pro-NH2
-
pH 7.5, 37°C, hydrolysis of pyroglutamyl-His-Pro-7-amido-4-methylcoumarin
0.356
pyroglutamyl-L-alpha-phenylglycyl-Pro-NH2
-
pH 7.5, 37°C, hydrolysis of pyroglutamyl-His-Pro-7-amido-4-methylcoumarin
0.0731
pyroglutamyl-Phe-Pro-NH2
-
37°C
0.232
pyroglutamyl-Trp-Pro-NH2
-
pH 7.5, 37°C, hydrolysis of pyroglutamyl-His-Pro-7-amido-4-methylcoumarin