3.4.19.6: pyroglutamyl-peptidase II

This is an abbreviated version!
For detailed information about pyroglutamyl-peptidase II, go to the full flat file.

Reaction

release of the N-terminal pyroglutamyl group from pGlu-/-His-Xaa tripeptides and pGlu-/-His-Xaa-Gly tetrapeptides =

Synonyms

aminopeptidase, thyrotropin-releasing factor pyroglutamate, PAP type II, PPII, pyroglutamate aminopeptidase II, pyroglutamyl aminopeptidase II, pyroglutamyl peptidase II, pyrrolidone carboxypeptidase type II, thyroliberin-hydrolyzing pyroglutamate aminopeptidase, thyroliberinase, thyrotropin-releasing hormone-degrading peptidase, thyrotropin-releasing hormone-degrading pyroglutamate aminopeptidase, TRH aminopeptidase, TRH-DE, TRH-degrading ectoenzyme, TRH-degrading enzyme, TRH-specific aminopeptidase

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.19 Omega peptidases

                3.4.19.6 pyroglutamyl-peptidase II

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Results	in table
4	Activating Compound
11	AA Sequence
5	Application
1	CAS Registry Number
2	Cloned(Commentary)
7	General Information
8	General Stability
126	Inhibitors
77	Ki Value [mM]
23	KM Value [mM]
20	Localization
6	Metals/Ions
12	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
37	Organism
4	pH Optimum
2	pH Range
1	pH Stability
4	Posttranslational Modification
13	Protein Variants
8	Purification (Commentary)
1	Reaction
5	Reaction Type
37	Reference
66	Source Tissue
5	Specific Activity [micromol/min/mg]
4	Storage Stability
64	Substrates and Products (Substrate)
7	Subunits
36	Synonyms
3	Temperature Optimum [°C]
2	Temperature Range [°C]
6	Temperature Stability [°C]
2	Turnover Number [1/s]

Inhibitors

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of the Enzyme Summary Page.

Inhibitors on EC 3.4.19.6 - pyroglutamyl-peptidase II

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

1,3-benzodioxol-5-amine

Rattus norvegicus

-

-

667505

1,7-phenanthroline

Bos taurus

-

10 mM, 67% inhibition

95299

2-Aminobenzyl alcohol

Rattus norvegicus

-

-

667505

2-hydroxyaniline

Rattus norvegicus

-

-

667505

2-Phenylethylamine

Rattus norvegicus

-

-

667505

3,4-dimethoxyaniline

Rattus norvegicus

-

-

667505

3,5-dimethoxyaniline

Rattus norvegicus

-

-

667505

3-(trifluoromethoxy)aniline

Rattus norvegicus

-

-

667505

3-phenyl-1-propylamine

Rattus norvegicus

-

-

667505

4,7-phenanthroline

Bos taurus

-

10 mM, 56% inhibition

95299

4-(2-aminoethyl)-benzenesulfonylfluoride

Bos taurus

-

66% inhibition at 1 mM, 97% inhibition at 10 mM

95299

4-(trifluoromethyl)aniline

Rattus norvegicus

-

-

667505

4-amino-N-methylphthalamide

Rattus norvegicus

-

-

667505

4-phenylbutylamine

Rattus norvegicus

-

-

667505

5,6,7,8-tetrahydro-1-naphthylamine

Rattus norvegicus

-

-

667505

5-amino-2-chloropyridine

Rattus norvegicus

-

-

667505

5-amino-2-methoxyphenol

Rattus norvegicus

-

-

667505

5-aminoindan

Rattus norvegicus

-

-

667505

5-chloro-2-methoxyaniline

Rattus norvegicus

-

-

667505

5-oxoproline

Sus scrofa

-

product inhibition at high concentration

647283

6-amino-1,3-dihydroisobenzofuran-1-one

Rattus norvegicus

-

-

667505

6-amino-2-mercaptobenzothiazole

Rattus norvegicus

-

-

667505

6-amino-3,4-benzocoumarin

Rattus norvegicus

-

-

667505

7-amino-4-methylcoumarin

Rattus norvegicus

-

-

667505

8-hydroxyquinoline

Bos taurus

-

10 mM, 68% inhibition

95299

aniline

Rattus norvegicus

-

-

667505

benzyl alcohol

Rattus norvegicus

-

-

667505

benzylamine

Rattus norvegicus

-

-

667505

Cd2+

2 entries

CDTA

Bos taurus

-

10 mM, 10% inhibition

95299

Chelating agents

Sus scrofa

-

-

647277, 647283

CuSO4

2 entries

DTT

Sus scrofa

-

-

647277

EDTA

3 entries

Glp-Asn-Pro-D-Tyr-D-Trp-7-amido-4-methyl-coumarin

Rattus norvegicus

-

-

683791, 689202

Glp-Asn-Pro-D-Tyr-D-Trp-D-Trp-7-amido-4-methyl-coumarin

Rattus norvegicus

-

-

683791, 689202

Glp-Asn-Pro-D-Tyr-D-TrpNH2

Rattus norvegicus

-

potent inhibitor of TRH-DE. Competetive, fully reversible and not time dependent inhibition

683791, 689202

Glp-Asn-Pro-Tyr-Trp-7-amido-4-methyl-coumarin

Rattus norvegicus

-

-

683791, 689202

Glp-Asn-Pro-Tyr-Trp-Trp-7-amido-4-methyl-coumarin

Rattus norvegicus

-

-

683791, 689202

Glp-Asn-Pro-Tyr-TrpNH2

Rattus norvegicus

-

-

683791, 689202

Glp-PSI[P(O)(OH)CH2]-His-Pro-NH2

3 entries

Hermodice carunculata inhibitor

2 entries

-

Hermodice carunculata peptidase inhibitor

Rattus norvegicus

-

HcPI

700583

-

Hg2+

2 entries

His-Pro-NH2

Sus scrofa

-

product inhibition at high concentration

647283

L-pyroglutamyl-Asn-Pro-NH2

Sus scrofa

-

inhibition is fully reversible

647285

Luliberin

2 entries

Luteinizing hormone releasing hormone

Bos taurus

-

-

95299

m-anisidine

Rattus norvegicus

-

-

667505

m-phenethidine

Rattus norvegicus

-

-

667505

metal chelators

2 entries

-

methyl alcohol

Rattus norvegicus

-

-

667505

methylamine

Rattus norvegicus

-

-

667505

MgSO4

Bos taurus

-

0.1 mM

95299

NEM

Bos taurus

-

10 mM, 22% inhibition

95299

neurotensin

Sus scrofa

-

-

647282

Ni2+

Sus scrofa

-

-

647277

o-anisidine

Rattus norvegicus

-

-

667505

p-anisidine

Rattus norvegicus

-

-

667505

p-Glu-Asn-Pro-7-amido-4-methylcoumarin

Rattus norvegicus

Q10836

-

732377

PCMB

Sus scrofa

-

-

647277

Peptides containing N-terminal pyroglutamyl residues

Cavia porcellus

-

-

95278

-

puromycin

Bos taurus

-

1 mM, 17% inhibition

95299

pyroglutamyl-7-amido-4-methylcoumarin

Bos taurus

-

-

95299

pyroglutamyl-Asn(N-benzyl)-ProNH2

Rattus norvegicus

-

-

667505

pyroglutamyl-Asn(N-hydroxyl)-ProNH2

Rattus norvegicus

-

-

667505

pyroglutamyl-Asn(N-methyl)-ProNH2

Rattus norvegicus

-

-

667505

pyroglutamyl-Asn(N-phenyl)-ProNH2

Rattus norvegicus

-

-

667505

pyroglutamyl-Asn-Pro-7-amido-4-methyl coumarin

Sus scrofa

-

-

647285

pyroglutamyl-Asn-Pro-7-amido-4-methylcoumarin

Rattus norvegicus

-

-

667505

pyroglutamyl-Asn-Pro-NH2

Sus scrofa

-

-

647285

pyroglutamyl-Asn-Pro-Ser-TyrNH2

Rattus norvegicus

-

-

667505

pyroglutamyl-Asn-Pro-Trp-7-amido-4-methylcoumarin

Rattus norvegicus

-

-

667505

pyroglutamyl-Asn-Pro-Trp-Trp-7-amido-4-methylcoumarin

Rattus norvegicus

-

-

667505

pyroglutamyl-Asn-Pro-Trp-TyrNH2

Rattus norvegicus

-

-

667505

pyroglutamyl-Asn-Pro-TrpNH2

Rattus norvegicus

-

-

667505

pyroglutamyl-Asn-Pro-Tyr-Trp-7-amido-4-methylcoumarin

Rattus norvegicus

-

-

667505

pyroglutamyl-Asn-Pro-Tyr-Trp-Trp-7-amido-4-methylcoumarin

Rattus norvegicus

-

-

667505

pyroglutamyl-Asn-Pro-Tyr-Trp-TrpNH2

Rattus norvegicus

-

-

667505

pyroglutamyl-Asn-Pro-Tyr-TrpNH2

Rattus norvegicus

-

-

667505

pyroglutamyl-Asn-Pro-TyrNH2

Rattus norvegicus

-

-

667505

pyroglutamyl-Asn-ProNH2

Rattus norvegicus

-

-

667505

pyroglutamyl-Gln-Pro-NH2

Sus scrofa

-

-

647285

pyroglutamyl-Gly-Pro-NH2

Sus scrofa

-

inhibition is fully reversible

647285

pyroglutamyl-His

Bos taurus

-

-

95299

Pyroglutamyl-His-Gly

Bos taurus

-

-

95299

pyroglutamyl-His-Gly-NH2

Bos taurus

-

-

95299

pyroglutamyl-His-Pro

Bos taurus

-

-

95299

pyroglutamyl-His-Pro-7-amido-4-methylcoumarin

Bos taurus

-

-

95299

pyroglutamyl-His-Pro-Gly

Bos taurus

-

-

95299

pyroglutamyl-His-Pro-Gly-NH2

Bos taurus

-

-

95299

pyroglutamyl-His-Pro-NH2

Bos taurus

-

-

95299

pyroglutamyl-His-Trp-Ser-Tyr-Gly

Bos taurus

-

-

95299

pyroglutamyl-His-Trp-Ser-Tyr-Gly-Leu

Bos taurus

-

-

95299

pyroglutamyl-His-Trp-Ser-Tyr-Gly-Leu-Arg

Bos taurus

-

-

95299

pyroglutamyl-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly

Bos taurus

-

-

95299

pyroglutamyl-homoprolyl-Pro-NH2

Sus scrofa

-

-

647285

pyroglutamyl-L-alpha-phenylglycyl-Pro-NH2

Sus scrofa

-

-

647285

pyroglutamyl-Phe-Pro-NH2

Bos taurus

-

-

95299

pyroglutamyl-Trp-Pro-NH2

Sus scrofa

-

-

647285

Thyroliberin analogues

Sus scrofa

-

LLD-thyroliberin, pyroglutamyl-His-Pro-NHCH3, pyroglutamyl-His-Pro-Gly-NHCH3, pyroglutamyl-Phe-Pro-NH2

647282

-

ZnSO4

2 entries

additional information

6 entries

-

Cd2+

Bos taurus

-

50% inhibition at 0.1 mM CsSO4, 98% inhibition at 1 mM

95299

Cd2+

Sus scrofa

-

-

647277

CuSO4

Bos taurus

-

0.1 mM

95299

CuSO4

Sus scrofa

-

-

647277

EDTA

Bos taurus

-

10 mM, 29% inhibition

95299

EDTA

Oryctolagus cuniculus

-

-

647281

EDTA

Sus scrofa

-

-

647277

Glp-PSI[P(O)(OH)CH2]-His-Pro-NH2

Mammalia

-

phosphinic analogue of thyrotropin releasing hormone, ED50 170 nM

699721

Glp-PSI[P(O)(OH)CH2]-His-Pro-NH2

Rattus norvegicus

-

phosphinic analogue of thyrotropin releasing hormone

700583

Glp-PSI[P(O)(OH)CH2]-His-Pro-NH2

Rattus norvegicus

Q10836

-

732377

Hermodice carunculata inhibitor

Mus musculus

-

-

647288

-

Hermodice carunculata inhibitor

Rattus norvegicus

-

the inhibitor is found in Hermodice carunculata and purified, MW below 1000 Da, the inhibitor is not a peptide

647288

-

Hg2+

Bos taurus

-

1 mM HgSO4, 76% inhibition

95299

Hg2+

Sus scrofa

-

-

647277

Luliberin

Cavia porcellus

-

inhibits hydrolysis of thyroliberin competitively

95278

Luliberin

Sus scrofa

-

-

647282

metal chelators

Oryctolagus cuniculus

-

-

647279

-

metal chelators

Sus scrofa

-

-

647277

-

ZnSO4

Bos taurus

-

1 mM ZnSO4, 61% inhibition

95299

ZnSO4

Sus scrofa

-

-

647277

additional information

Oryctolagus cuniculus

-

no inhibition by aspartyl protease inhibitors; no inhibition by cysteine protease inhibitors; no inhibition by serine protease inhibitors

647279

-

additional information

Oryctolagus cuniculus

-

no inhibition by bacitracin; no inhibition by puromycin

647281

-

additional information

Rattus norvegicus

-

PPII inhibitory activity als detected in Phallusia nigra, Palythoa caribaeorum and Mycale microsigmatosa

647288

-

additional information

Rattus norvegicus

-

expression of PPII is downregulated in amygdala of yoked rats (immersed in a tank with no platform or spatial cues) and rats trained to find a hidden platform in water after 5 min of day 1 and 5. In hippocampus, no significant variations are observed for PPII expression at any time

689171

-

additional information

Sus scrofa

-

no inhibition by NEM; no inhibition by serine protease inhibitors; no inhition by 2-iodoacetamide

647277

-

additional information

Sus scrofa

-

no inhibition by chlordiazepoxide; no inhibition by DTNB; no inhibition by NEM; no inhibition by pepstatin; no inhition by 2-iodoacetamide

647283

-