3.4.18.1: cathepsin X
This is an abbreviated version!
For detailed information about cathepsin X, go to the full flat file.
Word Map on EC 3.4.18.1
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3.4.18.1
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cathepsins
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papain-like
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procathepsins
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saitoi
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diagnostics
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galactosialidosis
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medicine
- 3.4.18.1
- cathepsins
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papain-like
-
procathepsins
- saitoi
- diagnostics
-
galactosialidosis
- medicine
Reaction
Release of C-terminal amino acid residues with broad specificity, but lacks action on C-terminal proline. Shows weak endopeptidase activity =
Synonyms
acid carboxypeptidase, cathepsin B2, cathepsin IV, cathepsin P, cathepsin X, cathepsin Z, CATX, CTPZ, CTSX, CTSZ, cysteine-type carboxypeptidase, lysosomal carboxypeptidase B, mopre, PoCtX
ECTree
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Localization
Localization on EC 3.4.18.1 - cathepsin X
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luminal protein-protein interactions between components of the cargo system in the endoplasmic reticulum for secretion of cargo proteins, e.g. cathepsin C or cathepsin Z, involve the cargo transport receptor ERGIC-53, i.e. endoplasmic reticulum-Golgi intermediate compartment protein of 53 kDa, with its luminal interaction partner MCFD2, i.e. multiple coagulation factor deficiency protein 2, overview
dislocation of CTPZ from the cortical granules
luminal protein-protein interactions between components of the cargo system in the endoplasmic reticulum for secretion of cargo proteins, e.g. cathepsin C or cathepsin Z, involve the cargo transport receptor ERGIC-53, i.e. endoplasmic reticulum-Golgi intermediate compartment protein of 53 kDa, with its luminal interaction partner MCFD2, i.e. multiple coagulation factor deficiency protein 2, overview
additional information
cathepsin X is localized on the cell surface of primary osteoblasts
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somal, enzyme in close proximity to the mitochondria, the rough endoplasmic reticulum, and the nuclear membrane
cathepsin X shows marked co-localization with Mac-1 integrin receptor on the plasma membrane of differentiated THP-1 cells primed with Helicobacter pylori antigen of group A of therapy-resistant strains. Priming with Helicobacter pylori antigen of groupB of therapy-susceptible strains results in less extensive co-localization with Mac-1
additional information
although cathepsin X is a lysosomal protease, its localization and trafficking is dependent on the state of cell activation, and it is translocated towards the plasma membrane upon leukocyte activation
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additional information
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subcellular localization in aged and pathological brain tissues, overview, no activity in the extracellular space
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