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Literature summary for 3.4.18.1 extracted from

  • Staudt, N.D.; Aicher, W.K.; Kalbacher, H.; Stevanovic, S.; Carmona, A.K.; Bogyo, M.; Klein, G.
    Cathepsin X is secreted by human osteoblasts, digests CXCL-12 and impairs adhesion of hematopoietic stem and progenitor cells to osteoblasts (2010), Haematologica, 95, 1452-1460.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.18.1

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface cathepsin X is localized on the cell surface of primary osteoblasts Homo sapiens 9986
-
extracellular secretion Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CXCL-12 + H2O Homo sapiens CXCL-12 is a physiological substrate for secreted cathepsin X ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9UBR2
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bone marrow cathepsin X can be secreted by nonhematopoietic bone marrow cells in an activated form Homo sapiens
-
bone marrow stromal cell
-
 Homo sapiens
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CAL-72 cell an osteoblastic cell line Homo sapiens
-
L87/4 cell a bone marrow stromal cell line Homo sapiens
-
L88/5 cell a bone marrow stromal cell line Homo sapiens
-
additional information no enzyme secretion from hematopoietic stem and progenitor cells, e.g. CD34+ HSPC, G292 cells Homo sapiens
-
osteoblast
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7-methoxycoumarin-4-ylacetyl-RPPGFSAFK-N-epsilon-2,4-dinitrophenol + H2O fluorescence cathepsin X/A-selective substrate Homo sapiens ?
-
 ?
CXCL-12 + H2O CXCL-12 is a physiological substrate for secreted cathepsin X Homo sapiens ?
-
 ?
CXCL-12 + H2O chemokine CXCL-12 is a highly potent chemoattractant for HSC secreted by osteoblasts. The exo-peptidase cathepsin X gradually cleaves fifteen amino acids until proline P74 is present at the P2 position Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
cathepsin Z
-
 Homo sapiens
mopre cathepsin X belongs to the CA clan of cysteine peptidases Homo sapiens

General Information

General Information Comment Organism
physiological function cysteine cathepsin proteases are primarily involved in endolysosomal degradation, but also function extracellularly and in the nucleus. Cathepsin X is secreted by human osteoblasts, digests CXCL-12 and impairs adhesion of hematopoietic stem and progenitor cells, i.e. HSPC s, to osteoblasts. Cathepsin X can influence HSPC trafficking in the bone marrow Homo sapiens