3.4.18.1: cathepsin X

This is an abbreviated version!
For detailed information about cathepsin X, go to the full flat file.

Reaction

Release of C-terminal amino acid residues with broad specificity, but lacks action on C-terminal proline. Shows weak endopeptidase activity =

Synonyms

acid carboxypeptidase, cathepsin B2, cathepsin IV, cathepsin P, cathepsin X, cathepsin Z, CATX, CTPZ, CTSX, CTSZ, cysteine-type carboxypeptidase, lysosomal carboxypeptidase B, mopre, PoCtX

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.18 Cysteine-type carboxypeptidases

                3.4.18.1 cathepsin X

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Results	in table
5	Activating Compound
1259	AA Sequence
4	Application
1	CAS Registry Number
11	Cloned(Commentary)
1	Crystallization (Commentary)
341	Disease/ Diagnostics
3	Expression
17	General Information
34	Inhibitors
2	kcat/KM [mM/s]
4	Ki Value [mM]
13	KM Value [mM]
34	Localization
6	Molecular Weight [Da]
23	Natural Substrates/ Products (Substrates)
42	Organism
2	PDB ID
16	pH Optimum
4	pH Range
1	pH Stability
1	pI Value
7	Posttranslational Modification
8	Protein Variants
5	Purification (Commentary)
2	Reaction
2	Reaction Type
42	Reference
93	Source Tissue
8	Specific Activity [micromol/min/mg]
2	Storage Stability
137	Substrates and Products (Substrate)
2	Subunits
33	Synonyms
2	Temperature Optimum [°C]
1	Temperature Stability [°C]
12	Turnover Number [1/s]

Cloned

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Cloned on EC 3.4.18.1 - cathepsin X

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CLONED (Commentary)

ORGANISM

UNIPROT

LITERATURE

cathepsin X stable expression in Jurkat T cells

Homo sapiens

-

708379

cDNA encoding for the proenzyme of PoCtX (proPoCtX) is expressed in Escherichia coli as a 57 kDa fusion protein with glutathione S-transferase

Paralichthys olivaceus

Q58HF4

691910

DNA and amino acid sequence determination and analysis, expression analysis, expression of GST-tagged enzyme in Escherichia coli strain BL21

Cyprinus carpio

Q58HG7

683378

DNA and amino acid sequence determination and anaylsis, expression of wild-type and mutant procathepsin X

Homo sapiens

Q9UBR2

683638

expression in Escherichia coli

Patiria pectinifera

G1JRK2

731157

expression in Pichia pastoris

Fasciola gigantica

-

731770

expression of procathepsin X in Pichia pastoris as an alpha-factor fusion

Homo sapiens

-

708748

expression of recombinants in Escherichia coli

Homo sapiens

-

36392

expression of the proenzyme in Pichia pastoris

Homo sapiens

-

708738

gene CTSZ, cloning from cumulus cells surrounding oocytes, DNA and amino acid sequence determination, and expression anaylsis

Bos taurus

P05689

683222

genotype distributions of CTSZ and CTSZ3P in South African coloured population in metropolitan Cape Town, South Africa, genotyping, overview

Homo sapiens

Q9UBR2

683059