3.4.18.1: cathepsin X

This is an abbreviated version!
For detailed information about cathepsin X, go to the full flat file.

Reaction

Release of C-terminal amino acid residues with broad specificity, but lacks action on C-terminal proline. Shows weak endopeptidase activity =

Synonyms

acid carboxypeptidase, cathepsin B2, cathepsin IV, cathepsin P, cathepsin X, cathepsin Z, CATX, CTPZ, CTSX, CTSZ, cysteine-type carboxypeptidase, lysosomal carboxypeptidase B, mopre, PoCtX

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.18 Cysteine-type carboxypeptidases

                3.4.18.1 cathepsin X

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Results	in table
5	Activating Compound
1259	AA Sequence
4	Application
1	CAS Registry Number
11	Cloned(Commentary)
1	Crystallization (Commentary)
341	Disease/ Diagnostics
3	Expression
17	General Information
34	Inhibitors
2	kcat/KM [mM/s]
4	Ki Value [mM]
13	KM Value [mM]
34	Localization
6	Molecular Weight [Da]
23	Natural Substrates/ Products (Substrates)
42	Organism
2	PDB ID
16	pH Optimum
4	pH Range
1	pH Stability
1	pI Value
7	Posttranslational Modification
8	Protein Variants
5	Purification (Commentary)
2	Reaction
2	Reaction Type
42	Reference
93	Source Tissue
8	Specific Activity [micromol/min/mg]
2	Storage Stability
137	Substrates and Products (Substrate)
2	Subunits
33	Synonyms
2	Temperature Optimum [°C]
1	Temperature Stability [°C]
12	Turnover Number [1/s]

Expression

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Expression on EC 3.4.18.1 - cathepsin X

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

Helicobacter pylori antigens from subjects with gastritis, who are successful in eradicating the infection after antibiotic therapy, decrease the membrane expression of cathepsin X in THP-1 cells

Homo sapiens

Q9UBR2

708373

Helicobacter pylori antigens from subjects with gastritis, who are unsuccessful in eradicating the infection after antibiotic therapy, increase the membrane expression of cathepsin X in THP-1 cells

Homo sapiens

Q9UBR2

708373

the enzyme is upregulated in several types of cancer

Homo sapiens

Q9UBR2

755099