3.4.14.10: tripeptidyl-peptidase II

This is an abbreviated version!
For detailed information about tripeptidyl-peptidase II, go to the full flat file.

Word Map on EC 3.4.14.10

3.4.14.10

exopeptidase

tppii

ceroid

butabindide

subtilisin-like

oligopeptidase

collagen-related

cholecystokinin-8

gly-pro-x

medicine

Reaction

Release of an N-terminal tripeptide from a polypeptide =

Synonyms

aminopeptidase, tripeptidyl, II, cholecystokinin-inactivating peptidase, dTPP II, EC 3.4.14.8, hTPP II, mTPP II, PTP-A, TPII, TPP, TPP II, TPP-2, TPP-II, TPP2, TPPII, tripeptidyl aminopeptidase, tripeptidyl aminopeptidase I, tripeptidyl aminopeptidase I I, tripeptidyl aminopeptidase II, tripeptidyl peptidase, tripeptidyl peptidase II, tripeptidyl-peptidase-II, tripeptidylpeptidase II, TY-21 TPP

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.14 Dipeptidyl-peptidases and tripeptidyl-peptidases

3.4.14.10 tripeptidyl-peptidase II

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Results	in table
5	Activating Compound
2690	AA Sequence
3	Application
1	CAS Registry Number
17	Cloned(Commentary)
1	Crystallization (Commentary)
47	Disease/ Diagnostics
2	Expression
13	General Information
4	General Stability
6	IC50 Value
144	Inhibitors
111	kcat/KM [mM/s]
68	Ki Value [mM]
122	KM Value [mM]
32	Localization
15	Molecular Weight [Da]
10	Natural Substrates/ Products (Substrates)
86	Organism
1	PDB ID
15	pH Optimum
9	pH Range
1	pH Stability
19	Protein Variants
15	Purification (Commentary)
1	Reaction
1	Reaction Type
77	Reference
95	Source Tissue
7	Specific Activity [micromol/min/mg]
6	Storage Stability
102	Substrates and Products (Substrate)
22	Subunits
70	Synonyms
5	Temperature Optimum [°C]
1	Temperature Stability [°C]
111	Turnover Number [1/s]

Purification

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Purification on EC 3.4.14.10 - tripeptidyl-peptidase II

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5 entries

DEAE column chromatography and Resource RPC hydrophobic column chromatography

Homo sapiens

P29144

679494

DEAE Sephacel column chromatography and hydroxyapatite column chromatography

Porphyromonas gingivalis

699739

Ni Sepharose 6 column chromatography

partial

recombinant enzyme from Escherichia coli 790fold by ammonium sulfate fractionation, anion exchange chromatography, ultrafiltration, and gel filtration

Kitasatospora herbaricolor

D1MVE1

752530

recombinant protein with His-tag

Homo sapiens

P29144

732922

using polyethyleneimine precipitation, (NH4)2SO4 precipitation, dialysis, anion-exchange chromatography, hydrophobic interaction chromatography

3 entries