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3.4.14.10: tripeptidyl-peptidase II

This is an abbreviated version!
For detailed information about tripeptidyl-peptidase II, go to the full flat file.

Word Map on EC 3.4.14.10

Reaction

Release of an N-terminal tripeptide from a polypeptide =

Synonyms

aminopeptidase, tripeptidyl, II, cholecystokinin-inactivating peptidase, dTPP II, EC 3.4.14.8, hTPP II, mTPP II, PTP-A, TPII, TPP, TPP II, TPP-2, TPP-II, TPP2, TPPII, tripeptidyl aminopeptidase, tripeptidyl aminopeptidase I, tripeptidyl aminopeptidase I I, tripeptidyl aminopeptidase II, tripeptidyl peptidase, tripeptidyl peptidase II, tripeptidyl-peptidase-II, tripeptidylpeptidase II, TY-21 TPP

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.14 Dipeptidyl-peptidases and tripeptidyl-peptidases
                3.4.14.10 tripeptidyl-peptidase II

Inhibitors

Inhibitors on EC 3.4.14.10 - tripeptidyl-peptidase II

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(2S)-1-oxo-1-[(2S)-2-(5-propyl-1H-imidazol-2-yl)-2,3-dihydro-1H-indol-1-yl]butan-2-amine
-
IC50: 4 nM
(2S)-1-oxo-1-[(2S)-2-(5-propyl-1H-imidazol-2-yl)-2,3-dihydro-1H-indol-1-yl]propan-2-amine
-
IC50: 6 nM
(2S)-1-[(2S)-2-(5-ethyl-1H-imidazol-2-yl)-2,3-dihydro-1H-indol-1-yl]-1-oxopropan-2-amine
-
IC50: 23 nM
(2S)-2-[[(2S)-2-aminobutanoyl]amino]butanoic acid
-
-
(2S)-2-[[(2S)-2-aminobutanoyl]amino]pentanoic acid
-
-
(2S)-aminobutyryl-(4S)-fluoro-L-proline n-butylamide
-
-
(2S)-aminobutyryl-4-cis-benzyl-L-proline n-butylamide
-
-
(S)-valinyl-(S)-phenylalaninol amide
-
-
1,10-phenanthroline
-
-
2,2'-Dithiopyridine
-
strong
2-(2-amino-3-methyl-butyrylamino)-4-phenyl-butyric acid
-
-
2-amino-1-[2-(4-propyl-1H-imidazol-2-yl)-2,3-dihydroindol-1-yl]ethanone
-
IC50: 36 nM
2-amino-3-methyl-N-(3-phenyl-propyl)-butyramide
-
-
2-amino-3-methyl-N-phenethyl-butyramide
-
-
2-amino-N-benzyl-3-methyl-butyramide
-
-
3,4-dichloroisocoumarin
-
-
Acetyl-Val-Leu-Leu-Arg-Ala-Ser-Val-Ala
-
weak
Ala-Ala-Ala-OH
-
-
Ala-Ala-OH
-
-
Ala-Ala-Phe-chloromethyl ketone
Ala-Ala-Phe-chloromethylketone
Ala-Ala-Phe-CMK
-
-
Ala-Ala-Pro-Ala-OH
-
-
Ala-Phe-OH
-
-
Ala-Pro-Ala-OH
-
-
Ala-Pro-OH
-
-
aminobutyryl-L-Pro-n-butylamide
-
-
aminobutyryl-Phe-n-butylamide
-
-
aminobutyryl-Pro-n-butylamide
-
-
Arg-Ala-(dehydro)Ala-Val-Ala
-
-
Arg-Ala-(phospho)Ser-Val-Ala
-
-
Arg-Ala-DELTAAla-Val-Ala
-
competitive
Arg-Arg-Ala
-
-
Arg-Arg-Ala-(dehydro)Ala-Val-Ala
-
less effective than Arg-Ala-(dehydro)Ala-Val-Ala
Arg-Arg-Ala-(phospho)Ser-Val-Ala
-
inhibits cleavage of Leu-Arg bond, Gly-Val-Leu-Arg-Arg-Ala-(phospho)Ser-Val-Ala as substrate
Asp-Tyr-Met-OH
-
-
azetepane
-
-
azetidine
-
-
butabindide
butabindide oxalate
-
specific TPPII inhibitor
butyloxycarbonyl-Val-Nle-OH
-
-
CH3-Nle-Nle-NHCH3
-
-
CH3CO-Val-Nvl-OH
-
-
CH3OCO-Val-Nvl-OH
-
-
Cu2+
-
strong
Diazoacetyl norleucine methyl ester
-
weak
diisopropyl fluorophosphate
diphenyl [1-([1-[(2S)-2-aminobutanoyl]-2,3-dihydro-1H-indole-2-carbonyl]amino)-3-methylbutyl]phosphonate
irreversible variant of butabindide. almost 60fold more potent than butabindide
Gly-Gly-Phe-OH
-
-
Gly-Phe-OH
-
-
Gly-Trp-Met-OH
-
-
Gly-Trp-OH
-
-
Gly-Tyr-OH
-
-
Gly-Val-Phe-OH
-
-
Guanidinovaleric acid-Arg-Ala-(phospho)Ser-Val
-
-
Hg2+
-
strong, reversible by dialysis against 2 mM DTT
Ile-Pro-Ile-OH
-
-
iodoacetate
-
-
isovaleryl-L-Leu-L-Arg-L-Arg-L-Ala-L-Ser-L-Val-L-Ala
-
L-Ala-L-Ala-L-Phe-chloromethane
-
-
L-Ala-L-Ala-L-Phe-chloromethylketone
-
-
L-Val-L-Leu-L-Arg-L-Arg-L-Ala-L-Ser-L-Val-L-Ala
-
Leu-Arg-Arg-Ala-(phospho)Ser-Val
-
weak, Gly-Val-Leu-Arg-Arg-Ala-(phospho)Ser-Val-Ala as substrate
Leu-Arg-Arg-Ala-(phospho)Ser-Val-Ala
-
weak, Gly-Val-Leu-Arg-Arg-Ala-(phospho)Ser-Val-Ala as substrate
Met-Met-OH
-
-
Met-Tyr-OH
-
-
N-[[(L-arginyl-L-alanyl)amino](oxo)acetyl]-L-valyl-L-alanine
-
potent inhibitor
Nle-Nle-NHCH3
-
-
Nle-Nle-OH
-
-
pepstatin
-
weak
PhCH2-Val-Nvl-OH
-
-
PhCH2OCO-Val-Nle-O(CH2)3CH3
-
-
PhCH2OCO-Val-Val-OH
-
-
pipecolinic acid
-
-
piperidine
-
-
Ser-Val-Ala
-
-
Soybean trypsin inhibitor
-
weak
-
trans-epoxysuccinyl-L-leucinamido(4-guanidino)butane
-
i.e. E-64, weak
Val-(4-PhCH2O)Phe-OH
-
-
Val-(beta-naphthyl)Ala-OH
-
-
Val-(S)-cyclohexylalanyl-NH(CH2)3CH3
-
-
Val-(S)-cyclohexylalanyl-OH
-
-
Val-Ala-OH
-
-
Val-Leu-Arg-Arg-Ala-(phospho)Ser-Val-Ala
-
hydrolysis of Gly-Val-Leu-Arg-Arg-Ala-(phospho)Ser-Val-Ala
Val-Met-OH
-
-
Val-Nle-NH(CH2)3CH3
-
-
Val-Nle-NH(CH2)3Ph
-
-
Val-Nle-NHCH3
-
-
Val-Nle-O(CH2)3CH3
-
-
Val-Nle-OH
-
-
Val-Nvl-NH(CH2)3CH3
-
-
Val-Nvl-NHCH3
-
-
Val-Nvl-OH
-
-
Val-Phe-NH(CH2)3CH3
-
-
Val-Phe-NH(CH2)CH3
-
-
Val-Phe-NHCH3
-
-
Val-Phe-O(CH2)3CH3
-
-
Val-Phe-O(CH2)CH3
-
-
Val-Phe-OCH3
-
-
Val-Phe-OH
-
-
Val-phenylglycine-NHCH3
-
-
Val-phenylglycine-OH
-
-
Val-Tyr-NHCH3
-
-
Val-Tyr-OH
-
-
Val-Val-NHCH3
-
-
Val-Val-OH
-
-
Z-Gly-Leu-Ala-OH
-
-
additional information
-