3.4.14.10: tripeptidyl-peptidase II
This is an abbreviated version!
For detailed information about tripeptidyl-peptidase II, go to the full flat file.
Word Map on EC 3.4.14.10
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3.4.14.10
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exopeptidase
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tppii
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ceroid
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butabindide
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subtilisin-like
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oligopeptidase
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collagen-related
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cholecystokinin-8
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gly-pro-x
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medicine
- 3.4.14.10
-
exopeptidase
- tppii
-
ceroid
- butabindide
-
subtilisin-like
-
oligopeptidase
-
collagen-related
- cholecystokinin-8
-
gly-pro-x
- medicine
Reaction
Release of an N-terminal tripeptide from a polypeptide =
Synonyms
aminopeptidase, tripeptidyl, II, cholecystokinin-inactivating peptidase, dTPP II, EC 3.4.14.8, hTPP II, mTPP II, PTP-A, TPII, TPP, TPP II, TPP-2, TPP-II, TPP2, TPPII, tripeptidyl aminopeptidase, tripeptidyl aminopeptidase I, tripeptidyl aminopeptidase I I, tripeptidyl aminopeptidase II, tripeptidyl peptidase, tripeptidyl peptidase II, tripeptidyl-peptidase-II, tripeptidylpeptidase II, TY-21 TPP
ECTree
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Inhibitors
Inhibitors on EC 3.4.14.10 - tripeptidyl-peptidase II
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(2S)-1-oxo-1-[(2S)-2-(5-propyl-1H-imidazol-2-yl)-2,3-dihydro-1H-indol-1-yl]butan-2-amine
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IC50: 4 nM
(2S)-1-oxo-1-[(2S)-2-(5-propyl-1H-imidazol-2-yl)-2,3-dihydro-1H-indol-1-yl]propan-2-amine
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IC50: 6 nM
(2S)-1-[(2S)-2-(5-ethyl-1H-imidazol-2-yl)-2,3-dihydro-1H-indol-1-yl]-1-oxopropan-2-amine
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IC50: 23 nM
2-amino-1-[2-(4-propyl-1H-imidazol-2-yl)-2,3-dihydroindol-1-yl]ethanone
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IC50: 36 nM
Arg-Arg-Ala-(dehydro)Ala-Val-Ala
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less effective than Arg-Ala-(dehydro)Ala-Val-Ala
Arg-Arg-Ala-(phospho)Ser-Val-Ala
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inhibits cleavage of Leu-Arg bond, Gly-Val-Leu-Arg-Arg-Ala-(phospho)Ser-Val-Ala as substrate
diphenyl [1-([1-[(2S)-2-aminobutanoyl]-2,3-dihydro-1H-indole-2-carbonyl]amino)-3-methylbutyl]phosphonate
irreversible variant of butabindide. almost 60fold more potent than butabindide
Leu-Arg-Arg-Ala-(phospho)Ser-Val
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weak, Gly-Val-Leu-Arg-Arg-Ala-(phospho)Ser-Val-Ala as substrate
Leu-Arg-Arg-Ala-(phospho)Ser-Val-Ala
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weak, Gly-Val-Leu-Arg-Arg-Ala-(phospho)Ser-Val-Ala as substrate
Val-Leu-Arg-Arg-Ala-(phospho)Ser-Val-Ala
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hydrolysis of Gly-Val-Leu-Arg-Arg-Ala-(phospho)Ser-Val-Ala
additional information
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no inhibition by Val-Leu-Arg, isovaleryl-Val-Leu-Arg-Arg-Ala-Ser-Val-Ala, EDTA (with or without DTT)
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additional information
no or poor inhibition by Streptomyces subtilisin inhibitor (SSI), API-2, 4-chloromercuribenzoate, 2,2'-dithiodipyridine, iodoacetate, talopeptin, Streptomyces pepsin inhibitor (S-PI), amastatin, bestatin, and arphamenine A
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additional information
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no or poor inhibition by Streptomyces subtilisin inhibitor (SSI), API-2, 4-chloromercuribenzoate, 2,2'-dithiodipyridine, iodoacetate, talopeptin, Streptomyces pepsin inhibitor (S-PI), amastatin, bestatin, and arphamenine A
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