3.4.14.10: tripeptidyl-peptidase II
This is an abbreviated version!
For detailed information about tripeptidyl-peptidase II, go to the full flat file.
Word Map on EC 3.4.14.10
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3.4.14.10
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exopeptidase
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tppii
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ceroid
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butabindide
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subtilisin-like
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oligopeptidase
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collagen-related
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cholecystokinin-8
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gly-pro-x
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medicine
- 3.4.14.10
-
exopeptidase
- tppii
-
ceroid
- butabindide
-
subtilisin-like
-
oligopeptidase
-
collagen-related
- cholecystokinin-8
-
gly-pro-x
- medicine
Reaction
Release of an N-terminal tripeptide from a polypeptide =
Synonyms
aminopeptidase, tripeptidyl, II, cholecystokinin-inactivating peptidase, dTPP II, EC 3.4.14.8, hTPP II, mTPP II, PTP-A, TPII, TPP, TPP II, TPP-2, TPP-II, TPP2, TPPII, tripeptidyl aminopeptidase, tripeptidyl aminopeptidase I, tripeptidyl aminopeptidase I I, tripeptidyl aminopeptidase II, tripeptidyl peptidase, tripeptidyl peptidase II, tripeptidyl-peptidase-II, tripeptidylpeptidase II, TY-21 TPP
ECTree
3.4.14.10 tripeptidyl-peptidase IIAdvanced search results
results (
results (KI Value
KI Value on EC 3.4.14.10 - tripeptidyl-peptidase II
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Ki VALUE [mM] 
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
additional information
additional information
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Ki-value above 5 mM: Met-Met-OH, Asp-Tyr-OH, PhCH2-Val-Nvl-OH, PhCH2OCO-Val-Nvl-OH, CH3-Nl2-Nle-OCH3. Ki-value above 3.0 mM: CH3-Nle-Nle-NHCH3, PhCH2-Nle-Nle-NHCH3, PhCH2OCO-Val-Nle-O(CH2)3CH3. Ki-value above 0.5 mM: CH3CO-Val-Nvl-OH
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0.000011
butabindide
wild type enzyme, using 0.2 mM of substrate L-Ala-L-Ala-L-Phe-p-nitroanilide, in 100 mM potassium phosphate buffer, pH 7.5, containing 2 mM dithiothreitol, and 15% glycerol, at 37°C
0.000015
butabindide
wild type enzyme, using 0.02 mM of substrate L-Ala-L-Ala-L-Phe-p-nitroanilide, in 100 mM potassium phosphate buffer, pH 7.5, containing 2 mM dithiothreitol, and 15% glycerol, at 37°C
0.14
butabindide
mutant enzyme E331Q, in 100 mM potassium phosphate buffer, pH 7.5, containing 2 mM dithiothreitol, and 15% glycerol, at 37°C
0.001
L-Val-L-Leu-L-Arg-L-Arg-L-Ala-L-Ser-L-Val-L-Ala
wild type enzyme, in 100 mM potassium phosphate buffer, pH 7.5, containing 2 mM dithiothreitol, and 15% glycerol, at 37°C
2
L-Val-L-Leu-L-Arg-L-Arg-L-Ala-L-Ser-L-Val-L-Ala
mutant enzyme E331Q, in 100 mM potassium phosphate buffer, pH 7.5, containing 2 mM dithiothreitol, and 15% glycerol, at 37°C
