3.4.14.10: tripeptidyl-peptidase II

This is an abbreviated version!
For detailed information about tripeptidyl-peptidase II, go to the full flat file.

Word Map on EC 3.4.14.10

3.4.14.10

exopeptidase

tppii

ceroid

butabindide

subtilisin-like

oligopeptidase

collagen-related

cholecystokinin-8

gly-pro-x

medicine

Reaction

Release of an N-terminal tripeptide from a polypeptide =

Synonyms

aminopeptidase, tripeptidyl, II, cholecystokinin-inactivating peptidase, dTPP II, EC 3.4.14.8, hTPP II, mTPP II, PTP-A, TPII, TPP, TPP II, TPP-2, TPP-II, TPP2, TPPII, tripeptidyl aminopeptidase, tripeptidyl aminopeptidase I, tripeptidyl aminopeptidase I I, tripeptidyl aminopeptidase II, tripeptidyl peptidase, tripeptidyl peptidase II, tripeptidyl-peptidase-II, tripeptidylpeptidase II, TY-21 TPP

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.14 Dipeptidyl-peptidases and tripeptidyl-peptidases

3.4.14.10 tripeptidyl-peptidase II

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Results	in table
5	Activating Compound
2690	AA Sequence
3	Application
1	CAS Registry Number
17	Cloned(Commentary)
1	Crystallization (Commentary)
47	Disease/ Diagnostics
2	Expression
13	General Information
4	General Stability
6	IC50 Value
144	Inhibitors
111	kcat/KM [mM/s]
68	Ki Value [mM]
122	KM Value [mM]
32	Localization
15	Molecular Weight [Da]
10	Natural Substrates/ Products (Substrates)
86	Organism
1	PDB ID
15	pH Optimum
9	pH Range
1	pH Stability
19	Protein Variants
15	Purification (Commentary)
1	Reaction
1	Reaction Type
77	Reference
95	Source Tissue
7	Specific Activity [micromol/min/mg]
6	Storage Stability
102	Substrates and Products (Substrate)
22	Subunits
70	Synonyms
5	Temperature Optimum [°C]
1	Temperature Stability [°C]
111	Turnover Number [1/s]

Cloned

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Cloned on EC 3.4.14.10 - tripeptidyl-peptidase II

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3 entries

an 8 kb NcoI fragment covering the 5'-flanking region of the TPP2 gene, including the initiation codon, is cloned into a luciferase-containing reporter vector. HEK-293 cells and NIH3T3 cells are transiently transfected with the construct. Through sequential deletions and analysis of short PCR-fragments, the promoter can be localized to a 215 bp fragment upstream of the initiation codon

Homo sapiens

665037

expressed in Escherichia coli

3 entries

expressed in Escherichia coli JM109(pTD-lac-NdeI-PTPA-L2R1) cells

Porphyromonas gingivalis

699739

expressed in Pichia pastoris

Mus musculus

Q64514

696417

expression in Escherichia coli

2 entries

expression of murine TPP2 gene optimized for high-level expression in Escherichia coli

Mus musculus

Q64514

731331

gene tpp, DNA and amino acid sequence determination and analysis, recombinant expression of extracellular enzyme in Escherichia coli strains JM109 and XL-1 Blue

Kitasatospora herbaricolor

D1MVE1

752530

normal and alternatively spliced cDNA variant which contains an additional 39 bp, encoding 13 amino acids in the C-terminal end of the protein, expression in human kidney 293 cells

Mus musculus

647154

overexpression in 293-cells, enzyme forms active oligomers

Mus musculus

647153

overexpression in 293-cells, enzyme i mainly in a nonassociated, inactive state

Homo sapiens

647153