Literature summary for 3.4.14.10 extracted from

Seyit, G.; Rockel, B.; Baumeister, W.; Peters, J.
Size matters: the spindle form of the 6 MDA tripeptidylpeptidase II from drosophila melanogaster stabilizes the activated state (2006), J. Biol. Chem., 281, 25723-25733.

Search for more literature for 3.4.14.10

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Drosophila sp. (in: flies)

General Stability

General Stability	Organism
spindle formation (at TPP II concentrations above 0.03 mg/ml) by strand paring causes both significant thermodynamic and kinetic stabilization	Drosophila sp. (in: flies)

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.44	-	Ala-Ala-Phe-7-amido-4-methylcoumarin	pH 7.5, 30°C, recombinant enzyme	Drosophila sp. (in: flies)
0.47	-	Ala-Ala-Phe-7-amido-4-methylcoumarin	pH 7.5, 30°C, native enzyme	Drosophila sp. (in: flies)

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining

Organism

Organism	UniProt	Comment	Textmining
Drosophila sp. (in: flies)	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Drosophila sp. (in: flies)

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Ala-Ala-Phe-7-amido-4-methylcoumarin + H2O	-	Drosophila sp. (in: flies)	Ala-Ala-Phe + 7-amino-4-methylcoumarin	-	?

Subunits

Subunits	Comment	Organism
More	TPP II is a large homooligomeric complex of about 6 MDa. Spindle formation (at TPP II concentrations above 0.03 mg/ml) by strand paring causes both significant thermodynamic and kinetic stabilization	Drosophila sp. (in: flies)

Synonyms

Synonyms	Comment	Organism
TPP II	-	Drosophila sp. (in: flies)

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Release 2023.1 (January 2023)