3.4.13.20: beta-Ala-His dipeptidase

This is an abbreviated version!
For detailed information about beta-Ala-His dipeptidase, go to the full flat file.

Reaction

preferential hydrolysis of the beta-Ala-/-His dipeptide (carnosine), and also anserine, Xaa-/-His dipeptides and other dipeptides including homocarnosine =

Synonyms

carnosinase, carnosinase-1, CN1, CN2, CNDP dipeptidase 2, CNDP1, CNDP2, cytosolic non-specific dipeptidase 2, DmpA, EC 3.4.13.13, EC 3.4.13.3, EC 3.4.3.3, serum carnosinase, tissue carnosinase

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.13 Dipeptidases

                3.4.13.20 beta-Ala-His dipeptidase

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Results	in table
2	Activating Compound
820	AA Sequence
11	Application
1	CAS Registry Number
10	Cloned(Commentary)
4	Crystallization (Commentary)
519	Disease/ Diagnostics
4	General Information
1	General Stability
23	Inhibitors
11	kcat/KM [mM/s]
2	Ki Value [mM]
23	KM Value [mM]
4	Localization
6	Metals/Ions
18	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
76	Organism
4	Pathway
4	PDB ID
10	pH Optimum
2	pH Stability
1	pI Value
7	Posttranslational Modification
22	Protein Variants
8	Purification (Commentary)
1	Reaction
1	Reaction Type
45	Reference
28	Source Tissue
1	Specific Activity [micromol/min/mg]
2	Storage Stability
104	Substrates and Products (Substrate)
11	Subunits
37	Synonyms
7	Temperature Optimum [°C]
6	Temperature Stability [°C]
14	Turnover Number [1/s]

KCat KM Value

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KCat KM Value on EC 3.4.13.20 - beta-Ala-His dipeptidase

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kcat/KM VALUE [1/mMs^-1]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

7800

beta-Ala-4-nitroanilide

Brucella anthropi

Q59632

pH 8.0, 25°C

708078

2600

beta-homoAla-4-nitroanilide

Brucella anthropi

Q59632

pH 8.0, 25°C

708078

0.027

beta-homoPhe-4-nitroanilide

Brucella anthropi

Q59632

pH 8.0, 25°C

708078

6.3 - 7.5

D-Ala-4-nitroanilide

2 entries

23

Gly-4-nitroanilide

Brucella anthropi

Q59632

100 mM Tris/HCl or 0 mM potassium phosphate, pH 8.0, 30°C

707418

0.8 - 1.55

L-Ala-4-nitroanilide

2 entries

0.35

L-Arg-4-nitroanilide

Brucella anthropi

Q59632

50 mM potassium phosphate, pH 8.0, 30°C

707418

0.275

L-Lys-4-nitroanilide

Brucella anthropi

Q59632

50 mM potassium phosphate, pH 8.0, 30°C

707418

0.017

L-Phe-4-nitroanilide

Brucella anthropi

Q59632

50 mM potassium phosphate, pH 8.0, 30°C

707418

6.3

D-Ala-4-nitroanilide

Brucella anthropi

Q59632

50 mM potassium phosphate, pH 8.0, 30°C

707418

7.5

D-Ala-4-nitroanilide

Brucella anthropi

Q59632

100 mM Tris/HCl, pH 8.0, 30°C

707418

0.8

L-Ala-4-nitroanilide

Brucella anthropi

Q59632

100 mM Tris/HCl, pH 8.0, 30°C

707418

1.55

L-Ala-4-nitroanilide

Brucella anthropi

Q59632

50 mM potassium phosphate, pH 8.0, 30°C

707418