Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

Disease on EC 3.4.13.20 - beta-Ala-His dipeptidase

Please use the Disease Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
4-aminobutyrate-2-oxoglutarate transaminase deficiency
Inherited disorders of GABA metabolism.
Albuminuria
Detection of carnosinase-1 in urine of healthy individuals and patients with type 2 diabetes: correlation with albuminuria and renal function.
Serum Carnosinase-1 and Albuminuria Rather than the CNDP1 Genotype Correlate with Urinary Carnosinase-1 in Diabetic and Nondiabetic Patients with Chronic Kidney Disease.
Urinary Carnosinase-1 Excretion is Associated with Urinary Carnosine Depletion and Risk of Graft Failure in Kidney Transplant Recipients: Results of the TransplantLines Cohort Study.
Asthma
Proteomic Analysis of Serum Differentially Expressed Proteins Between Allergic Bronchopulmonary Aspergillosis and Asthma.
Bacterial Infections
Transition metal ions induce carnosinase activity in PepD-homologous protein from Porphyromonas gingivalis.
beta-ala-his dipeptidase deficiency
A deletion in the long arm of chromosome 18 in a child with serum carnosinase deficiency.
A fluorometric micromethod for estimation of carnosinase in dried blood samples.
A novel, quantitative assay for homocarnosine in cerebrospinal fluid using stable-isotope dilution liquid chromatography-tandem mass spectrometry.
Carnosinase activity of human gastrointestinal mucosa.
Carnosinase deficiency: a new variant with high residual activity.
Carnosinase, diabetes mellitus and the potential relevance of carnosinase deficiency.
Homocarnosinosis: influence of dietary restriction of histidine.
Homocarnosinosis: lack of serum carnosinase is the defect probably responsible for elevated brain and CSF homocarnosine.
Impairment of electron transfer chain induced by acute carnosine administration in skeletal muscle of young rats.
Inborn errors of carnosine and homocarnosine metabolism.
Inherited disorders of GABA metabolism.
Neurological disease in a child with carnosinase deficiency.
Plasma carnosinase deficiency in patients with urea cycle defects.
Reduced serum carnosinase activity in hypothyroidism.
Serum carnosinase deficiency concomitant with mental retardation.
Serum carnosinase deficiency: a non-disabling phenotype?
[Serum carnosinase deficiency and homocarnosinosis]
Brain Injuries
Effect of minimized perfusion circuit on brain injury markers carnosinase and brain-type fatty binding protein in coronary artery bypass grafting patients.
Cardiovascular Diseases
Relationship between carnosinase gene CNDP1 leucine repeat polymorphism and the clinical outcome of Chinese PD patients.
Cataract
State of the art clinical efficacy and safety evaluation of N-acetylcarnosine dipeptide ophthalmic prodrug. Principles for the delivery, self-bioactivation, molecular targets and interaction with a highly evolved histidyl-hydrazide structure in the treatment and therapeutic management of a group of sight-threatening eye diseases.
Structural and functional properties, chaperone activity and posttranslational modifications of alpha-crystallin and its related subunits in the crystalline lens: N-acetylcarnosine, carnosine and carcinine act as alpha- crystallin/small heat shock protein enhancers in prevention and dissolution of cataract in ocular drug delivery formulations of novel therapeutic agents.
Central Nervous System Diseases
Serum carnosinase activities in central nervous system disorders.
Coronary Disease
Allelic variation in the CNDP1 gene and its lack of association with longevity and coronary heart disease.
Dementia
Brain type carnosinase in dementia: a pilot study.
Diabetes Complications
Aerobic and resistance training do not influence plasma carnosinase content or activity in type 2 diabetes.
CNDP1 knockout in zebrafish alters the amino acid metabolism, restrains weight gain, but does not protect from diabetic complications.
Low plasma carnosinase activity promotes carnosinemia after carnosine ingestion in humans.
Reduced muscle carnosine content in type 2, but not in type 1 diabetic patients.
Diabetes Mellitus
A leucine repeat in the carnosinase gene CNDP1 is associated with diabetic end-stage renal disease in European Americans.
A polymorphism in the gene encoding carnosinase (CNDP1) as a predictor of mortality and progression from nephropathy to end-stage renal disease in type 1 diabetes mellitus.
Carnosinase concentration, activity, and CNDP1 genotype in patients with type 2 diabetes with and without nephropathy.
Carnosinase, diabetes mellitus and the potential relevance of carnosinase deficiency.
Exclusion of polymorphisms in carnosinase genes (CNDP1 & CNDP2) as cause of diabetic nephropathy in type 1 diabetes mellitus. Results of large case - control and follow - up studies.
Diabetes Mellitus, Type 1
A polymorphism in the gene encoding carnosinase (CNDP1) as a predictor of mortality and progression from nephropathy to end-stage renal disease in type 1 diabetes mellitus.
Exclusion of polymorphisms in carnosinase genes (CNDP1 & CNDP2) as cause of diabetic nephropathy in type 1 diabetes mellitus. Results of large case - control and follow - up studies.
Exclusion of polymorphisms in carnosinase genes (CNDP1 and CNDP2) as a cause of diabetic nephropathy in type 1 diabetes: results of large case-control and follow-up studies.
Genotype Distribution of CNDP1 Polymorphisms in the Healthy Chinese Han Population: Association with HbA1c and Fasting Blood Glucose.
Re: Exclusion of polymorphisms in carnosinase genes (CNDP1 and CNDP2) as a cause of diabetic nephropathy in type 1 diabetes: results of large case-control and follow-up studies.
Diabetes Mellitus, Type 2
A polymorphism in the gene encoding carnosinase (CNDP1) as a predictor of mortality and progression from nephropathy to end-stage renal disease in type 1 diabetes mellitus.
Aerobic and resistance training do not influence plasma carnosinase content or activity in type 2 diabetes.
Allosteric inhibition of carnosinase (CN1) by inducing a conformational shift.
Association between CNDP1 genotype and diabetic nephropathy is sex-specific.
Carnosinase concentration, activity, and CNDP1 genotype in patients with type 2 diabetes with and without nephropathy.
Carnosinase, diabetes mellitus and the potential relevance of carnosinase deficiency.
Common variants in CNDP1 and CNDP2, and risk of nephropathy in type 2 diabetes.
Detection of carnosinase-1 in urine of healthy individuals and patients with type 2 diabetes: correlation with albuminuria and renal function.
Genotype Distribution of CNDP1 Polymorphisms in the Healthy Chinese Han Population: Association with HbA1c and Fasting Blood Glucose.
Serum Carnosinase-1 and Albuminuria Rather than the CNDP1 Genotype Correlate with Urinary Carnosinase-1 in Diabetic and Nondiabetic Patients with Chronic Kidney Disease.
Sex specific association between carnosinase gene CNDP1 and cardiovascular mortality in patients with type 2 diabetes (ZODIAC-22).
The CNDP1 (CTG)5 Polymorphism Is Associated with Biopsy-Proven Diabetic Nephropathy, Time on Hemodialysis, and Diabetes Duration.
The influence of a single nucleotide polymorphism within CNDP1 on susceptibility to diabetic nephropathy in Japanese women with type 2 diabetes.
The influence of carnosinase gene polymorphisms on diabetic nephropathy risk in African-Americans.
Diabetic Nephropathies
A CTG polymorphism in the CNDP1 gene determines the secretion of serum carnosinase in Cos-7 transfected cells.
A polymorphism in the gene encoding carnosinase (CNDP1) as a predictor of mortality and progression from nephropathy to end-stage renal disease in type 1 diabetes mellitus.
Allosteric inhibition of carnosinase (CN1) by inducing a conformational shift.
Association between CNDP1 genotype and diabetic nephropathy is sex-specific.
Association of CTG repeat polymorphism in carnosine dipeptidase 1 (CNDP1) gene with diabetic nephropathy in north Indians.
Association of variants in the carnosine peptidase 1 gene (CNDP1) with diabetic nephropathy in American Indians.
Carnosinase concentration, activity, and CNDP1 genotype in patients with type 2 diabetes with and without nephropathy.
Carnosinase, diabetes mellitus and the potential relevance of carnosinase deficiency.
Carnosinase-1 overexpression, but not aerobic exercise training, affects the development of advanced diabetic nephropathy in BTBR ob/ob mice.
Carnosine as a protective factor in diabetic nephropathy: association with a leucine repeat of the carnosinase gene CNDP1.
Carnosine metabolism in diabetes is altered by reactive metabolites.
Carnosine Prevents Apoptosis of Glomerular Cells and Podocyte Loss in STZ Diabetic Rats.
Carnosine treatment largely prevents alterations of renal carnosine metabolism in diabetic mice.
CNDP1 genotype and renal survival in pediatric nephropathies.
CNDP1 knockout in zebrafish alters the amino acid metabolism, restrains weight gain, but does not protect from diabetic complications.
CNDP1, NOS3, and MnSOD Polymorphisms as Risk Factors for Diabetic Nephropathy among Type 2 Diabetic Patients in Malaysia.
Common variants in CNDP1 and CNDP2, and risk of nephropathy in type 2 diabetes.
Correlation between serum carnosinase concentration and renal damage in diabetic nephropathy patients.
D18S880 Microsatellite Polymorphism of Carnosinase Gene and Diabetic Nephropathy: A Meta-Analysis.
Detection of carnosinase-1 in urine of healthy individuals and patients with type 2 diabetes: correlation with albuminuria and renal function.
Exclusion of polymorphisms in carnosinase genes (CNDP1 & CNDP2) as cause of diabetic nephropathy in type 1 diabetes mellitus. Results of large case - control and follow - up studies.
Exclusion of polymorphisms in carnosinase genes (CNDP1 and CNDP2) as a cause of diabetic nephropathy in type 1 diabetes: results of large case-control and follow-up studies.
Genetic factors in diabetic nephropathy.
Genotype Distribution of CNDP1 Polymorphisms in the Healthy Chinese Han Population: Association with HbA1c and Fasting Blood Glucose.
Homology modeling of human serum carnosinase, a potential medicinal target, and MD simulations of its allosteric activation by citrate.
Human carnosinase 1 overexpression aggravates diabetes and renal impairment in BTBROb/Ob mice.
Identification and characterisation of carnostatine (SAN9812), a potent and selective carnosinase (CN1) inhibitor with in vivo activity.
Low plasma carnosinase activity promotes carnosinemia after carnosine ingestion in humans.
Lower frequency of the 5/5 homozygous CNDP1 genotype in South Asian Surinamese.
Mining the genome for susceptibility to diabetic nephropathy: the role of large-scale studies and consortia.
Re: Exclusion of polymorphisms in carnosinase genes (CNDP1 and CNDP2) as a cause of diabetic nephropathy in type 1 diabetes: results of large case-control and follow-up studies.
Sex specific association between carnosinase gene CNDP1 and cardiovascular mortality in patients with type 2 diabetes (ZODIAC-22).
The CNDP1 (CTG)5 Polymorphism Is Associated with Biopsy-Proven Diabetic Nephropathy, Time on Hemodialysis, and Diabetes Duration.
The influence of a single nucleotide polymorphism within CNDP1 on susceptibility to diabetic nephropathy in Japanese women with type 2 diabetes.
The influence of carnosinase gene polymorphisms on diabetic nephropathy risk in African-Americans.
[Carnosine, carnosinase and kidney diseases].
Diabetic Retinopathy
State of the art clinical efficacy and safety evaluation of N-acetylcarnosine dipeptide ophthalmic prodrug. Principles for the delivery, self-bioactivation, molecular targets and interaction with a highly evolved histidyl-hydrazide structure in the treatment and therapeutic management of a group of sight-threatening eye diseases.
Eye Diseases
Structural and functional properties, chaperone activity and posttranslational modifications of alpha-crystallin and its related subunits in the crystalline lens: N-acetylcarnosine, carnosine and carcinine act as alpha- crystallin/small heat shock protein enhancers in prevention and dissolution of cataract in ocular drug delivery formulations of novel therapeutic agents.
Fatigue Syndrome, Chronic
Use of dynamic tests of muscle function and histomorphometry of quadriceps muscle biopsies in the investigation of patients with chronic alcohol misuse and chronic fatigue syndrome.
Gastrointestinal Neoplasms
Circulating carnosine dipeptidase 1 associates with weight loss and poor prognosis in gastrointestinal cancer.
Glaucoma, Neovascular
State of the art clinical efficacy and safety evaluation of N-acetylcarnosine dipeptide ophthalmic prodrug. Principles for the delivery, self-bioactivation, molecular targets and interaction with a highly evolved histidyl-hydrazide structure in the treatment and therapeutic management of a group of sight-threatening eye diseases.
Glioblastoma
Circulating carnosine dipeptidase 1 associates with weight loss and poor prognosis in gastrointestinal cancer.
Glomerulonephritis
Carnosinase, diabetes mellitus and the potential relevance of carnosinase deficiency.
Hemorrhagic Stroke
Serum neuron-specific enolase, carnosinase, and their ratio in acute stroke. An enzymatic test for predicting outcome?
Hyperglycemia
Aerobic and resistance training do not influence plasma carnosinase content or activity in type 2 diabetes.
N-glycosylation of carnosinase influences protein secretion and enzyme activity: implications for hyperglycemia.
Possible role of L-carnosine in the regulation of blood glucose through controlling autonomic nerves.
Hyperthyroidism
Reduced serum carnosinase activity in hypothyroidism.
Hypothyroidism
Reduced serum carnosinase activity in hypothyroidism.
Influenza, Human
Management of the Virulent Influenza Virus Infection by Oral Formulation of Nonhydrolized Carnosine and Isopeptide of Carnosine Attenuating Proinflammatory Cytokine-Induced Nitric Oxide Production.
Non-hydrolyzed in digestive tract and blood natural L-carnosine peptide ("bioactivated Jewish penicillin") as a panacea of tomorrow for various flu ailments: signaling activity attenuating nitric oxide (NO) production, cytostasis, and NO-dependent inhibition of influenza virus replication in macrophages in the human body infected with the virulent swine influenza A (H1N1) virus.
Insulin Resistance
Effect of carnosine supplementation on the plasma lipidome in overweight and obese adults: a pilot randomised controlled trial.
Novel Relationship Between Plasmalogen Lipid Signatures and Carnosine in Humans.
Intellectual Disability
Carnosinase deficiency: a new variant with high residual activity.
Histopathology of the nervous system in carnosinase enzyme deficiency with mental retardation.
Inborn errors of carnosine and homocarnosine metabolism.
Serum carnosinase deficiency concomitant with mental retardation.
Kidney Diseases
Association of CTG repeat polymorphism in carnosine dipeptidase 1 (CNDP1) gene with diabetic nephropathy in north Indians.
CNDP1 genotype and renal survival in pediatric nephropathies.
Kidney Failure, Chronic
A leucine repeat in the carnosinase gene CNDP1 is associated with diabetic end-stage renal disease in European Americans.
A polymorphism in the gene encoding carnosinase (CNDP1) as a predictor of mortality and progression from nephropathy to end-stage renal disease in type 1 diabetes mellitus.
Genotype Distribution of CNDP1 Polymorphisms in the Healthy Chinese Han Population: Association with HbA1c and Fasting Blood Glucose.
The influence of carnosinase gene polymorphisms on diabetic nephropathy risk in African-Americans.
Liver Diseases
Decreased activity of carnosinase in serum of patients with chronic liver disorders.
Serum carnosinase activities in patients with alcoholic chronic skeletal muscle myopathy.
Macular Degeneration
Structural and functional properties, chaperone activity and posttranslational modifications of alpha-crystallin and its related subunits in the crystalline lens: N-acetylcarnosine, carnosine and carcinine act as alpha- crystallin/small heat shock protein enhancers in prevention and dissolution of cataract in ocular drug delivery formulations of novel therapeutic agents.
Malnutrition
Circulating carnosine dipeptidase 1 associates with weight loss and poor prognosis in gastrointestinal cancer.
Metabolic Syndrome
Biological functions of histidine-dipeptides and metabolic syndrome.
Multiple Sclerosis
Serum carnosinase activities in central nervous system disorders.
Muscle Hypotonia
A deletion in the long arm of chromosome 18 in a child with serum carnosinase deficiency.
Muscle Spasticity
Carnosinase deficiency: a new variant with high residual activity.
Muscular Atrophy
Serum carnosinase activities in patients with alcoholic chronic skeletal muscle myopathy.
Muscular Diseases
Fluorometric assay of human serum carnosinase activity in normal children, adults and patients with myopathy.
Serum carnosinase activities in patients with alcoholic chronic skeletal muscle myopathy.
The relationship between muscle fibre atrophy factor, plasma carnosinase activities and muscle RNA and protein composition in chronic alcoholic myopathy.
Neoplasms
Carnosinases, their substrates and diseases.
Circulating carnosine dipeptidase 1 associates with weight loss and poor prognosis in gastrointestinal cancer.
Generation of monospecific antibodies based on affinity capture of polyclonal antibodies.
Proteins with altered levels in plasma from glioblastoma patients as revealed by iTRAQ-based quantitative proteomic analysis.
The antineoplastic effect of carnosine is accompanied by induction of PDK4 and can be mimicked by L-histidine.
Underexpressed CNDP2 participates in gastric cancer growth inhibition through activating the MAPK signaling pathway.
Nephrotic Syndrome
Primer: strategies for identifying genes involved in renal disease.
Nervous System Diseases
Carnosinases, their substrates and diseases.
Homology modeling of human serum carnosinase, a potential medicinal target, and MD simulations of its allosteric activation by citrate.
Serum carnosinase activities in central nervous system disorders.
Neurologic Manifestations
Carnosinase deficiency: a new variant with high residual activity.
Obesity
The Combined Effects of Genetic Variation in the CNDP1 and CNDP2 Genes and Dietary Carbohydrate and Carotene Intake on Obesity Risk.
Optic Atrophy
Carnosinase deficiency: a new variant with high residual activity.
Parkinson Disease
Serum carnosinase activities in central nervous system disorders.
Peripheral Nervous System Diseases
Carnosinase deficiency: a new variant with high residual activity.
Polyneuropathies
Neurological disease in a child with carnosinase deficiency.
Prostatic Neoplasms
Circulating carnosine dipeptidase 1 associates with weight loss and poor prognosis in gastrointestinal cancer.
Quadriplegia
Carnosinase deficiency: a new variant with high residual activity.
Renal Insufficiency
CNDP1 genotype and renal survival in pediatric nephropathies.
Renal Insufficiency, Chronic
Carnosinase, diabetes mellitus and the potential relevance of carnosinase deficiency.
CNDP1 genotype and renal survival in pediatric nephropathies.
Is carnosinase 1 gene (CNDP1) polymorphism associated with chronic kidney disease progression in children and young adults? results of a family-based study.
Serum Carnosinase-1 and Albuminuria Rather than the CNDP1 Genotype Correlate with Urinary Carnosinase-1 in Diabetic and Nondiabetic Patients with Chronic Kidney Disease.
Urinary Carnosinase-1 Excretion is Associated with Urinary Carnosine Depletion and Risk of Graft Failure in Kidney Transplant Recipients: Results of the TransplantLines Cohort Study.
[Carnosine, carnosinase and kidney diseases].
Retinal Artery Occlusion
State of the art clinical efficacy and safety evaluation of N-acetylcarnosine dipeptide ophthalmic prodrug. Principles for the delivery, self-bioactivation, molecular targets and interaction with a highly evolved histidyl-hydrazide structure in the treatment and therapeutic management of a group of sight-threatening eye diseases.
Retinal Vein Occlusion
State of the art clinical efficacy and safety evaluation of N-acetylcarnosine dipeptide ophthalmic prodrug. Principles for the delivery, self-bioactivation, molecular targets and interaction with a highly evolved histidyl-hydrazide structure in the treatment and therapeutic management of a group of sight-threatening eye diseases.
Seizures
A deletion in the long arm of chromosome 18 in a child with serum carnosinase deficiency.
Inherited disorders of GABA metabolism.
Stroke
Serum carnosinase activities in central nervous system disorders.
Serum neuron-specific enolase, carnosinase, and their ratio in acute stroke. An enzymatic test for predicting outcome?
succinate-semialdehyde dehydrogenase [nad(p)+] deficiency
Inherited disorders of GABA metabolism.
Virus Diseases
Management of the Virulent Influenza Virus Infection by Oral Formulation of Nonhydrolized Carnosine and Isopeptide of Carnosine Attenuating Proinflammatory Cytokine-Induced Nitric Oxide Production.
Non-hydrolyzed in digestive tract and blood natural L-carnosine peptide ("bioactivated Jewish penicillin") as a panacea of tomorrow for various flu ailments: signaling activity attenuating nitric oxide (NO) production, cytostasis, and NO-dependent inhibition of influenza virus replication in macrophages in the human body infected with the virulent swine influenza A (H1N1) virus.