3.4.13.20: beta-Ala-His dipeptidase

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For detailed information about beta-Ala-His dipeptidase, go to the full flat file.

Reaction

preferential hydrolysis of the beta-Ala-/-His dipeptide (carnosine), and also anserine, Xaa-/-His dipeptides and other dipeptides including homocarnosine =

Synonyms

carnosinase, carnosinase-1, CN1, CN2, CNDP dipeptidase 2, CNDP1, CNDP2, cytosolic non-specific dipeptidase 2, DmpA, EC 3.4.13.13, EC 3.4.13.3, EC 3.4.3.3, serum carnosinase, tissue carnosinase

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.13 Dipeptidases

                3.4.13.20 beta-Ala-His dipeptidase

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Results	in table
2	Activating Compound
820	AA Sequence
11	Application
1	CAS Registry Number
10	Cloned(Commentary)
4	Crystallization (Commentary)
519	Disease/ Diagnostics
4	General Information
1	General Stability
23	Inhibitors
11	kcat/KM [mM/s]
2	Ki Value [mM]
23	KM Value [mM]
4	Localization
6	Metals/Ions
18	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
76	Organism
4	Pathway
4	PDB ID
10	pH Optimum
2	pH Stability
1	pI Value
7	Posttranslational Modification
22	Protein Variants
8	Purification (Commentary)
1	Reaction
1	Reaction Type
45	Reference
28	Source Tissue
1	Specific Activity [micromol/min/mg]
2	Storage Stability
104	Substrates and Products (Substrate)
11	Subunits
37	Synonyms
7	Temperature Optimum [°C]
6	Temperature Stability [°C]
14	Turnover Number [1/s]

Crystallization

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Crystallization on EC 3.4.13.20 - beta-Ala-His dipeptidase

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

active-site modeling of DmpA. Based on the crystal structure and the catalytic mechanism proposed for DmpA, carnosine is manually introduced into the active site of the enzyme. The model shows that carnosine fits excellently, in line with the high specific activity for this substrate

Brucella anthropi

Q59632

708078

crystal structure of the enzyme determined to 1.82 A resolution using the multiple isomorphous replacement method. The heterodimer folds into a single domain organised as an alphabetabetaalpha sandwich in which two mixed beta sheets are flanked on both sides by two alpha helices

Brucella anthropi

Q59632

710582

hangig-drop vapor-diffusion method. Two crystal forms are obtained at 21°C in 13-16% PEG 2000 monomethylether at pH 9.0, adding either 0.2 M magnesium chloride or 1 M lithium chloride. Crystals of the first form belong to the space group C222(1) and diffract to 3.0 A resolution. Crystals of the second form belong to the space group P2(1)2(1)2 and diffract to 2.3 A resolution

Brucella anthropi

Q59632

706948

complexed with bestatin together with Zn2+, hanging drop vapour diffusion method, using 20% polyethylene glycol 3350 and 0.2 M potassium fluoride

Mus musculus

-

698808