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3.4.13.20: beta-Ala-His dipeptidase

This is an abbreviated version!
For detailed information about beta-Ala-His dipeptidase, go to the full flat file.

Word Map on EC 3.4.13.20

Reaction

preferential hydrolysis of the beta-Ala-/-His dipeptide (carnosine), and also anserine, Xaa-/-His dipeptides and other dipeptides including homocarnosine =

Synonyms

carnosinase, carnosinase-1, CN1, CN2, CNDP dipeptidase 2, CNDP1, CNDP2, cytosolic non-specific dipeptidase 2, DmpA, EC 3.4.13.13, EC 3.4.13.3, EC 3.4.3.3, serum carnosinase, tissue carnosinase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.13 Dipeptidases
                3.4.13.20 beta-Ala-His dipeptidase

Inhibitors

Inhibitors on EC 3.4.13.20 - beta-Ala-His dipeptidase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
3-(acetylamino)-L-alanyl-L-histidine
-
2.3 mM, 50% inhibition of 3-nitrotyrosine formation
3-amino-L-alanyl-L-histidine
-
3.3 mM, 50% inhibition of 3-nitrotyrosine formation
AgNO3
30°C, 10 min, 1 mM, 95% loss of activity
bestatin
CdCl2
30°C, 10 min, 1 mM, 90% loss of activity
citrate
-
citrate ions are shown to bind at only three well-defined sites involving both ion pairs and hydrogen bonds. Molecular dynamics simulations evidence that citrate binding has a remarkable conformational influence on the 3D structure of carnosinase, increasing the binding affinity of carnosine to the catalytic site
cysteine
lowers dose-dependently recombinant CN1 efficiency
dithiothreitol
30°C, 10 min, 1 mM, 63% loss of activity
EDTA
-
-
HgCl2
30°C, 10 min, 1 mM, 99% loss of activity
homocarnosine
-
-
N-acetyl-3-(acetylamino)-L-alanyl-L-histidine
-
2.5 mM, 50% inhibition of 3-nitrotyrosine formation
N-acetylcysteine
lowers dose-dependently recombinant CN1 efficiency
N-ethylmaleimide
30°C, 10 min, 1 mM, 80% loss of activity
p-chloromercuribenzoate
30°C, 10 min, 1 mM, 95% loss of activity
reduced glutathione
lowers dose-dependently recombinant CN1 efficiency
ZnCl2
30°C, 10 min, 1 mM, 98% loss of activity
ZnSO4
30°C, 10 min, 1 mM, 98% loss of activity
additional information
-