3.4.13.20: beta-Ala-His dipeptidase
This is an abbreviated version!
For detailed information about beta-Ala-His dipeptidase, go to the full flat file.
Word Map on EC 3.4.13.20
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3.4.13.20
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carnosine
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dipeptide
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nephropathy
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anserine
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homocarnosine
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beta-alanyl-l-histidine
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l-histidine
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bestatin
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n-acetylcarnosine
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histidine-containing
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carcinine
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medicine
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analysis
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synthesis
- 3.4.13.20
- carnosine
- dipeptide
- nephropathy
- anserine
- homocarnosine
- beta-alanyl-l-histidine
- l-histidine
- bestatin
-
n-acetylcarnosine
-
histidine-containing
-
carcinine
- medicine
- analysis
- synthesis
Reaction
preferential hydrolysis of the beta-Ala-/-His dipeptide (carnosine), and also anserine, Xaa-/-His dipeptides and other dipeptides including homocarnosine =
Synonyms
carnosinase, carnosinase-1, CN1, CN2, CNDP dipeptidase 2, CNDP1, CNDP2, cytosolic non-specific dipeptidase 2, DmpA, EC 3.4.13.13, EC 3.4.13.3, EC 3.4.3.3, serum carnosinase, tissue carnosinase
ECTree
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Inhibitors
Inhibitors on EC 3.4.13.20 - beta-Ala-His dipeptidase
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3-(acetylamino)-L-alanyl-L-histidine
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2.3 mM, 50% inhibition of 3-nitrotyrosine formation
3-amino-L-alanyl-L-histidine
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3.3 mM, 50% inhibition of 3-nitrotyrosine formation
citrate
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citrate ions are shown to bind at only three well-defined sites involving both ion pairs and hydrogen bonds. Molecular dynamics simulations evidence that citrate binding has a remarkable conformational influence on the 3D structure of carnosinase, increasing the binding affinity of carnosine to the catalytic site
N-acetyl-3-(acetylamino)-L-alanyl-L-histidine
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2.5 mM, 50% inhibition of 3-nitrotyrosine formation
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no inhibition by p-hydroxymercuribenzoate, CH2ClCOONa, phenylmethylsulfonyl fluoride
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additional information
no inhibition: o-phenanthroline, 8-hydroxyquinoline, ethylenediaminetetraacetic acid, 2,2'-dipyridyl, hydroxylamine, phenylhydrazine, hydrazine, D,L-penicillamine, D-cycloserine, phenylmethanesulfonyl fluoride, leupeptine, pepstatin, LiCl, H2BO3, NaCl, MgSO4, MgCl2, AlCl3, KCl, CaCl2, CrCl3, MnSO4, MnCl2, FeSO4, FeCl3, CoCl2, NiCl2, CuSO4, CuCl2, RbCl, Na2MoO4 (NH4)6Mo7O24, SnCl2, CsCl, BaCl2 and PbCl2
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