3.4.13.18: cytosol nonspecific dipeptidase

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For detailed information about cytosol nonspecific dipeptidase, go to the full flat file.

Reaction

hydrolysis of dipeptides, preferentially hydrophobic dipeptides including prolyl amino acids =

Synonyms

carboxypeptidase of glutamate like-B, CG17337, CNDP2, CPGL, CPGL-B, diglycinase, dipeptidase, glycylglycine, DPP8, DPP8-v3, EC 3.4.13.1, EC 3.4.13.11, EC 3.4.13.13, EC 3.4.13.15, EC 3.4.13.2, EC 3.4.13.3, EC 3.4.13.8, EC 3.4.3.1, EC 3.4.3.2, EC 3.4.3.3, EC 3.4.3.6, Gly-Leu hydrolase, glycyl-glycine dipeptidase, glycyl-L-leucine dipeptidase, glycyl-L-leucine hydrolase, glycyl-L-leucine peptidase, glycyl-leucine dipeptidase, glycylleucine dipeptidase, glycylleucine dipeptide hydrolase, glycylleucine hydrolase, glycylleucine peptidase, human cytosolic non-specific dipeptidase, iminodipeptidase, L-amino-acyl-L-amino-acid hydrolase, L-prolylglycine dipeptidase, N2-beta-alanylarginine dipeptidase, non-specific dipeptidase, PepD, Peptidase A, Pro-X dipeptidase, Pro-Xaa dipeptidase, prolinase, prolyl dipeptidase

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.13 Dipeptidases

                3.4.13.18 cytosol nonspecific dipeptidase

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Results	in table
10	Activating Compound
1878	AA Sequence
2	CAS Registry Number
6	Cloned(Commentary)
132	Disease/ Diagnostics
1	General Information
14	General Stability
14	IC50 Value
89	Inhibitors
99	KM Value [mM]
13	Localization
24	Metals/Ions
25	Molecular Weight [Da]
1	Natural Substrates/ Products (Substrates)
228	Organism
7	Pathway
6	PDB ID
17	pH Optimum
1	pH Range
9	pH Stability
1	pI Value
4	Protein Variants
22	Purification (Commentary)
1	Reaction
1	Reaction Type
52	Reference
74	Source Tissue
14	Specific Activity [micromol/min/mg]
6	Storage Stability
211	Substrates and Products (Substrate)
11	Subunits
55	Synonyms
4	Temperature Optimum [°C]
8	Temperature Stability [°C]
41	Turnover Number [1/s]

pH Stability

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pH Stability on EC 3.4.13.18 - cytosol nonspecific dipeptidase

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pH STABILITY

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

6

Mus musculus

-

6 h, 80% loss of activity, ascites tumor enzyme

137178

6.2 - 9

Escherichia coli

-

6 h stable

137178

6.7

Mus musculus

-

6 h, 80% loss of activity, mouse ascites tumor enzyme

137178

7

Mus musculus

-

6 h, 25-30% loss of activity, mouse ascites tumor enzyme

137178

7 - 10

Mycolicibacterium phlei

-

most stable

137181

7.3 - 8.3

Sus scrofa

-

maximal stability at 50°C for 30 min

137176

7.5 - 8.5

Mus musculus

-

stable

137174

8.1 - 8.3

Mus musculus

-

6 h, stable

137178

8.9

Mus musculus

-

6 h, 25-30% loss of activity, mouse ascites tumor enzyme

137178