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Ala-Ala-p-nitroanilide + H2O
Ala-Ala + p-nitroaniline
-
-
-
?
Ala-Pro-p-nitroanilide + H2O
Ala-Pro + p-nitroaniline
Arg-Pro-p-nitroanilide + H2O
Arg-Pro + p-nitroaniline
Asp-Pro-p-nitroanilide + H2O
Asp-Pro + p-nitroaniline
beta-Ala-L-His + H2O
beta-Ala + L-His
D-Leu-Gly + H2O
D-Leu + Gly
Gly-His + H2O
Gly + His
-
-
-
?
Gly-L-Ala + H2O
Gly + L-Ala
-
-
-
-
?
Gly-L-Asn + H2O
Gly + L-Asn
-
-
-
-
?
Gly-L-Lys + H2O
Gly + L-Lys
-
-
-
-
?
Gly-Pro-p-nitroanilide + H2O
Gly-Pro + p-nitroaniline
Gly-Tyr + H2O
Gly + Tyr
-
-
-
?
His-Ala + H2O
His + Ala
-
-
-
?
Hyp-Gly + H2O
Hyp + Gly
-
-
-
?
L-Ala-4-methylcoumarin 7-amide + H2O
L-Ala + 7-amino-4-methylcoumarin
L-Ala-Gly + H2O
L-Ala + Gly
L-Ala-L-Ser + H2O
L-Ala + L-Ser
-
-
-
?
L-Leu-L-Phe + H2O
L-Leu + L-Phe
-
-
-
-
?
L-Lys-4-methylcoumarin 7-amide + H2O
L-Lys + 7-amino-4-methylcoumarin
lactate + L-isoleucine
N-L-lactoyl-L-isoleucine + H2O
-
-
-
?
lactate + L-phenylalanine
N-L-lactoyl-L-phenylalanine + H2O
-
-
-
?
lactate + L-tryptophan
N-L-lactoyl-L-tryptophan + H2O
-
-
-
?
lactate + L-tyrosine
N-L-lactoyl-L-tyrosine + H2O
-
-
-
?
Leu-Arg + H2O
Leu + Arg
-
-
-
?
Leu-Leu-Leu + H2O
?
-
-
-
-
?
Leu-Pro-p-nitroanilide + H2O
Leu-Pro + p-nitroaniline
-
-
-
-
?
Leu-Ser + H2O
Leu + Ser
-
-
-
?
Lys-Pro-p-nitroanilide + H2O
Lys-Pro + p-nitroaniline
-
-
-
-
?
Met-Glu + H2O
Met + Glu
-
-
-
?
Met-Gly + H2O
Met + Gly
-
-
-
?
Met-Phe + H2O
Met + Phe
-
-
-
?
Met-Pro-p-nitroanilide + H2O
Met-Pro + p-nitroaniline
-
-
-
-
?
N-(3,5-dicarboxy-4-methyl-2-pyrrolcarbonyl)glycine + H2O
?
-
-
-
-
?
Phe-Leu + H2O
Phe + Leu
-
-
-
?
Phe-Met + H2O
Phe + Met
-
-
-
?
Pro-Asp + H2O
Pro + Asp
-
-
-
-
?
Pro-Glu + H2O
Pro + Glu
-
-
-
-
?
Pro-Ile + H2O
Pro + Ile
-
-
-
?
Pro-Leu-NH2 + H2O
Pro + Leu-NH2
-
-
-
?
Pro-Lys + H2O
Pro + Lys
-
-
-
?
Pro-Pro + H2O
Pro + Pro
-
-
-
?
Pro-Ser + H2O
Pro + Ser
-
-
-
-
?
Ser-Phe + H2O
Ser + Phe
-
-
-
?
Ser-Pro-p-nitroanilide + H2O
Ser-Pro + p-nitroaniline
-
-
-
-
?
Thr-Leu + H2O
Thr + Leu
-
-
-
?
additional information
?
-
Ala-Ala + H2O
Ala + Ala
-
-
-
?
Ala-Ala + H2O
Ala + Ala
-
-
-
?
Ala-Ile + H2O
Ala + Ile
-
best substrate for the tumor enzyme
-
?
Ala-Ile + H2O
Ala + Ile
-
best substrate for the tumor enzyme
-
?
Ala-Ile + H2O
Ala + Ile
-
-
-
?
Ala-Leu + H2O
Ala + Leu
-
-
-
?
Ala-Leu + H2O
Ala + Leu
-
-
-
?
Ala-Leu + H2O
Ala + Leu
-
-
-
?
Ala-Leu + H2O
Ala + Leu
-
-
-
?
Ala-Leu + H2O
Ala + Leu
-
-
-
?
Ala-Pro-p-nitroanilide + H2O
Ala-Pro + p-nitroaniline
-
-
-
?
Ala-Pro-p-nitroanilide + H2O
Ala-Pro + p-nitroaniline
-
-
-
-
?
Arg-Pro-p-nitroanilide + H2O
Arg-Pro + p-nitroaniline
-
-
-
?
Arg-Pro-p-nitroanilide + H2O
Arg-Pro + p-nitroaniline
-
-
-
-
?
Asp-Pro-p-nitroanilide + H2O
Asp-Pro + p-nitroaniline
-
-
-
?
Asp-Pro-p-nitroanilide + H2O
Asp-Pro + p-nitroaniline
-
-
-
-
?
beta-Ala-L-His + H2O
beta-Ala + L-His
-
-
-
-
?
beta-Ala-L-His + H2O
beta-Ala + L-His
-
-
-
-
?
carnosine + H2O
?
-
-
-
?
carnosine + H2O
?
-
-
-
?
carnosine + H2O
?
-
-
-
?
D-Leu-Gly + H2O
D-Leu + Gly
-
-
-
-
?
D-Leu-Gly + H2O
D-Leu + Gly
-
-
-
-
?
Gly-Gly + H2O
Gly + Gly
-
-
-
?
Gly-Gly + H2O
Gly + Gly
-
-
-
?
Gly-Ile + H2O
Gly + Ile
-
-
-
?
Gly-Ile + H2O
Gly + Ile
-
-
-
?
Gly-Leu + H2O
Gly + Leu
-
-
-
?
Gly-Leu + H2O
Gly + Leu
-
-
-
?
Gly-Leu + H2O
Gly + Leu
-
-
-
?
Gly-Leu + H2O
Gly + Leu
-
-
-
?
Gly-Leu + H2O
Gly + Leu
-
-
-
?
Gly-Leu + H2O
Gly + Leu
-
-
-
?
Gly-Leu + H2O
Gly + Leu
-
-
-
?
Gly-Leu + H2O
Gly + Leu
-
-
-
?
Gly-Leu + H2O
Gly + Leu
-
-
-
?
Gly-Phe + H2O
Gly + Phe
-
-
-
?
Gly-Phe + H2O
Gly + Phe
-
-
-
?
Gly-Phe + H2O
Gly + Phe
-
-
-
?
Gly-Pro-p-nitroanilide + H2O
Gly-Pro + p-nitroaniline
-
-
-
?
Gly-Pro-p-nitroanilide + H2O
Gly-Pro + p-nitroaniline
-
-
-
-
?
Gly-Val + H2O
Gly + Val
-
-
-
?
Gly-Val + H2O
Gly + Val
-
-
-
?
L-Ala-4-methylcoumarin 7-amide + H2O
L-Ala + 7-amino-4-methylcoumarin
-
-
-
-
?
L-Ala-4-methylcoumarin 7-amide + H2O
L-Ala + 7-amino-4-methylcoumarin
-
-
-
-
?
L-Ala-Gly + H2O
L-Ala + Gly
-
-
-
?
L-Ala-Gly + H2O
L-Ala + Gly
-
-
-
?
L-Ala-Gly + H2O
L-Ala + Gly
-
-
-
?
L-Ala-Gly + H2O
L-Ala + Gly
-
-
-
?
L-Ala-Gly + H2O
L-Ala + Gly
-
-
-
?
L-Ala-Gly + H2O
L-Ala + Gly
-
-
-
?
L-Ala-Gly + H2O
L-Ala + Gly
-
-
-
?
L-Ala-Gly + H2O
L-Ala + Gly
-
-
-
?
L-Lys-4-methylcoumarin 7-amide + H2O
L-Lys + 7-amino-4-methylcoumarin
-
-
-
-
?
L-Lys-4-methylcoumarin 7-amide + H2O
L-Lys + 7-amino-4-methylcoumarin
-
-
-
-
?
Leu-Gly + H2O
Leu + Gly
-
-
-
?
Leu-Gly + H2O
Leu + Gly
-
-
-
?
Leu-Gly + H2O
Leu + Gly
-
-
-
?
Leu-Gly + H2O
Leu + Gly
-
-
-
?
Leu-Gly + H2O
Leu + Gly
-
-
-
?
Leu-Gly + H2O
Leu + Gly
-
-
-
?
Leu-Leu + H2O
Leu + Leu
-
-
-
?
Leu-Leu + H2O
Leu + Leu
-
-
-
?
Leu-Leu + H2O
Leu + Leu
-
-
-
?
Leu-Leu + H2O
Leu + Leu
-
-
-
?
Leu-Leu + H2O
Leu + Leu
-
-
-
?
Leu-Leu + H2O
Leu + Leu
-
-
-
?
Met-Ala + H2O
Met + Ala
-
best substrate for E. coli enzyme
-
?
Met-Ala + H2O
Met + Ala
-
-
-
?
Met-Ala + H2O
Met + Ala
-
-
-
?
Met-Ala + H2O
Met + Ala
-
-
-
?
Met-Leu + H2O
Met + Leu
-
-
-
?
Met-Leu + H2O
Met + Leu
-
-
-
?
Phe-Gly + H2O
Phe + Gly
-
-
-
?
Phe-Gly + H2O
Phe + Gly
-
-
-
?
Pro-Ala + H2O
Pro + Ala
-
-
-
?
Pro-Ala + H2O
Pro + Ala
-
-
-
?
Pro-Ala + H2O
Pro + Ala
-
-
-
-
?
Pro-Ala + H2O
Pro + Ala
-
-
-
?
Pro-Ala + H2O
Pro + Ala
-
-
-
?
Pro-Gly + H2O
Pro + Gly
-
-
-
?
Pro-Gly + H2O
Pro + Gly
-
-
-
?
Pro-Gly + H2O
Pro + Gly
-
-
-
?
Pro-Gly + H2O
Pro + Gly
-
-
-
?
Pro-Gly + H2O
Pro + Gly
-
-
-
?
Pro-Gly + H2O
Pro + Gly
-
-
-
-
?
Pro-Gly + H2O
Pro + Gly
-
-
-
?
Pro-Gly + H2O
Pro + Gly
-
-
-
?
Pro-Gly + H2O
Pro + Gly
-
-
-
?
Pro-Gly + H2O
Pro + Gly
-
-
-
?
Pro-Leu + H2O
Pro + Leu
-
-
-
?
Pro-Leu + H2O
Pro + Leu
-
-
-
?
Pro-Leu + H2O
Pro + Leu
-
-
-
-
?
Pro-Leu + H2O
Pro + Leu
-
-
-
?
Pro-Leu + H2O
Pro + Leu
-
-
-
?
Pro-Leu + H2O
Pro + Leu
-
-
-
?
Pro-Leu + H2O
Pro + Leu
-
-
-
?
Pro-Leu + H2O
Pro + Leu
-
-
-
?
Pro-Leu + H2O
Pro + Leu
-
-
-
?
Pro-Leu + H2O
Pro + Leu
-
-
-
?
Pro-Leu + H2O
Pro + Leu
-
-
-
?
Pro-Met + H2O
Pro + Met
-
-
-
?
Pro-Met + H2O
Pro + Met
-
-
-
?
Pro-Met + H2O
Pro + Met
-
-
-
-
?
Pro-Met + H2O
Pro + Met
-
-
-
?
Pro-Met + H2O
Pro + Met
-
-
-
?
Pro-Phe + H2O
Pro + Phe
-
-
-
-
?
Pro-Phe + H2O
Pro + Phe
-
-
-
?
Pro-Phe + H2O
Pro + Phe
-
-
-
?
Pro-Val + H2O
Pro + Val
-
-
-
?
Pro-Val + H2O
Pro + Val
-
-
-
-
?
additional information
?
-
-
not: Gly-Pro
-
-
?
additional information
?
-
-
not: Gly-Pro
-
-
?
additional information
?
-
-
hydrolyzes dipeptides and dipeptidyl amides with L-proline or hydroxy-L-proline at the N-terminus
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
specificity overview
-
-
?
additional information
?
-
-
the tumor enzyme has the highest maximal velocities with substrates containing uncharged bulky C-terminal and small, uncharged N-terminal side chains, the bacterial enzyme hydrolyzes most rapidly substrates with long or flat N-terminal R-groups and small or positively charged C-terminal groups
-
-
?
additional information
?
-
-
only unsubstituted L-alpha-dipeptides
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
specificity overview
-
-
?
additional information
?
-
-
not: Gly-Pro
-
-
?
additional information
?
-
-
not: Gly-Pro
-
-
?
additional information
?
-
-
DPP8-v3 may play a key role in the immunoregulation of testes and accordingly may influence spermatogenesis and male fertility
-
-
?
additional information
?
-
-
the enzyme catalyzes cleavage at the carboxyl side of the proline residue at the penultimate position
-
-
?
additional information
?
-
CNDP2 catalyzes the formation of N-lactoyl-amino acids. The plasma levels of of N-lactoyl-amino acids strongly correlate with plasma levels of lactate and amino acids
-
-
?
additional information
?
-
-
not: Leu-Pro
-
-
?
additional information
?
-
-
not: Gly-Tyr
-
-
?
additional information
?
-
-
not: Leu-Pro
-
-
?
additional information
?
-
-
not: Gly-Tyr
-
-
?
additional information
?
-
-
not: Gly-Pro
-
-
?
additional information
?
-
-
not: Gly-Pro
-
-
?
additional information
?
-
-
broad specificity
-
-
?
additional information
?
-
-
specificity overview
-
-
?
additional information
?
-
-
specificity overview
-
-
?
additional information
?
-
-
not: Lys-Gly
-
-
?
additional information
?
-
-
not: Gly-Asp
-
-
?
additional information
?
-
-
peptides with small NH2-terminal and bulky nonpolar COOH-terminal R groups are preferred
-
-
?
additional information
?
-
-
the tumor enzyme has the highest maximal velocities with substrates containing uncharged bulky C-terminal and small, uncharged N-terminal side chains, the bacterial enzyme hydrolyzes most rapidly substrates with long or flat N-terminal R-groups and small or positively charged C-terminal groups
-
-
?
additional information
?
-
-
not: Asp-Gly
-
-
?
additional information
?
-
-
only unsubstituted L-alpha-dipeptides
-
-
?
additional information
?
-
-
only unsubstituted L-alpha-dipeptides
-
-
?
additional information
?
-
-
specificity overview
-
-
?
additional information
?
-
-
specificity overview
-
-
?
additional information
?
-
-
not: L-Pro-Gly
-
-
?
additional information
?
-
-
not: Gly-Gly
-
-
?
additional information
?
-
-
not: Gly-Gly
-
-
?
additional information
?
-
-
not: some of the arginine- and aspartic acid-containing dipeptides
-
-
?
additional information
?
-
-
not: Gly-Pro
-
-
?
additional information
?
-
-
not: Gly-L-His
-
-
?
additional information
?
-
-
not: Leu-Leu
-
-
?
additional information
?
-
-
not: Ala-Leu
-
-
?
additional information
?
-
-
no or very poor substrate: Leu-4-methylcoumarin 7-amide, Met-4-methylcoumarin 7-amide, Phe-4-methylcoumarin 7-amide, L-Lys-L-Ala-4-methylcoumarin 7-amide
-
-
?
additional information
?
-
-
no or very poor substrate: Leu-4-methylcoumarin 7-amide, Met-4-methylcoumarin 7-amide, Phe-4-methylcoumarin 7-amide, L-Lys-L-Ala-4-methylcoumarin 7-amide
-
-
?
additional information
?
-
-
substrates must contain uncharged side chains and free alpha-amino and carboxyl groups
-
-
?
additional information
?
-
-
specificity overview
-
-
?
additional information
?
-
-
not: anserine
-
-
?
additional information
?
-
-
not: Gly-Gly-Gly
-
-
?
additional information
?
-
-
not: N-Ac-Met
-
-
?
additional information
?
-
-
strictly L-stereospecific
-
-
?
additional information
?
-
-
some activity against peptides with 3 or more residues but none against peptides containing acidic or D-amino acids
-
-
?
additional information
?
-
-
no tripeptidase or arylamidase activity
-
-
?
additional information
?
-
-
only unsubstituted L-alpha-dipeptides
-
-
?
additional information
?
-
-
not: dipeptides containing beta-amino acids
-
-
?
additional information
?
-
-
not: homocarnosine
-
-
?
additional information
?
-
-
not: beta-Ala-Lys
-
-
?
additional information
?
-
-
not: Gly-His-Gly
-
-
?