3.4.13.18: cytosol nonspecific dipeptidase
This is an abbreviated version!
For detailed information about cytosol nonspecific dipeptidase, go to the full flat file.
Word Map on EC 3.4.13.18
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3.4.13.18
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prolidase
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3.4.13.11
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carnosinase
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glycosyl-phosphatidylinositol
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pro-leu
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iminopeptidase
- 3.4.13.18
- prolidase
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3.4.13.11
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carnosinase
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glycosyl-phosphatidylinositol
- pro-leu
- iminopeptidase
Reaction
hydrolysis of dipeptides, preferentially hydrophobic dipeptides including prolyl amino acids =
Synonyms
carboxypeptidase of glutamate like-B, CG17337, CNDP2, CPGL, CPGL-B, diglycinase, dipeptidase, glycylglycine, DPP8, DPP8-v3, EC 3.4.13.1, EC 3.4.13.11, EC 3.4.13.13, EC 3.4.13.15, EC 3.4.13.2, EC 3.4.13.3, EC 3.4.13.8, EC 3.4.3.1, EC 3.4.3.2, EC 3.4.3.3, EC 3.4.3.6, Gly-Leu hydrolase, glycyl-glycine dipeptidase, glycyl-L-leucine dipeptidase, glycyl-L-leucine hydrolase, glycyl-L-leucine peptidase, glycyl-leucine dipeptidase, glycylleucine dipeptidase, glycylleucine dipeptide hydrolase, glycylleucine hydrolase, glycylleucine peptidase, human cytosolic non-specific dipeptidase, iminodipeptidase, L-amino-acyl-L-amino-acid hydrolase, L-prolylglycine dipeptidase, N2-beta-alanylarginine dipeptidase, non-specific dipeptidase, PepD, Peptidase A, Pro-X dipeptidase, Pro-Xaa dipeptidase, prolinase, prolyl dipeptidase
ECTree
3.4.13.18 cytosol nonspecific dipeptidaseAdvanced search results
results (
results (Inhibitors
Inhibitors on EC 3.4.13.18 - cytosol nonspecific dipeptidase
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INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
(1S)-1-cyclohexyl-2-(1,3-dihydro-2H-isoindol-2-yl)-2-oxoethanamine
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IC50: 24 nM
(1S)-1-cyclohexyl-2-(3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethanamine
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IC50: 3016 nM
(2S)-1-[(2S)-2-amino-4-(3,4-dihydroisoquinolin-2(1H)-yl)-4-oxobutanoyl]pyrrolidine-2-carbonitrile
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IC50: 19 nM
(2S)-1-[(2S)-2-amino-4-(4-[bis(4-fluorophenyl)methyl]piperazin-1-yl)-4-oxobutanoyl]pyrrolidine-2-carbonitrile
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IC50: 16 nM
(2S)-2-amino-2-cyclohexyl-1-[(2R)-2-(iminomethyl)cyclopentyl]ethanone
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IC50: 27 nM
1-(1,3-dihydro-2H-isoindol-2-yl)-4-(3,4-dihydroisoquinolin-2(1H)-yl)-1,4-dioxobutan-2-amine
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IC50: 555 nM
1-(1,3-dihydro-2H-isoindol-2-yl)-4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-1,4-dioxobutan-2-amine
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IC50: 150 nM
4-(4-[bis(4-fluorophenyl)methyl]piperazin-1-yl)-1-(1,3-dihydro-2H-isoindol-2-yl)-1,4-dioxobutan-2-amine
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IC50: 14 nM
6-([2-({2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}amino)ethyl]amino)nicotinonitrile
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IC50: 4574 nM
DL-homocysteine
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strong inhibition at 10 and 50 mM, in the presence of 0.1 mM MnCl2
DL-methionine
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strong inhibition at 10 and 50 mM, in the presence of 0.1 mM MnCl2
L-leucine
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strong inhibition of prolinase activity against Pro-Gly regardless wether MnCl2 is present or not
L-Val
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strong inhibition of prolinase activity against Pro-Gly regardless wether MnCl2 is present or not
N-acetyl-L-methionine
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strong inhibition at 10 and 50 mM, in the presence of 0.1 mM MnCl2
additional information
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inhibition by high substrate concentrations is observed in cases where the Km is low
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Co2+
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when substrates are cleaved rapidly by dipeptidase, addition of Co2+ inhibits the reaction. The more slowly a substrate is hydrolyzed in the absence of metals, the greater the activating effect
Co2+
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hydrolysis of the relative poor substrates, Pro-Gly and Gly-Gly is activated, whereas that of Ala-Gly is inhibited
Mn2+
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when substrates are cleaved rapidly by dipeptidase, addition of Mn2+ inhibits the reaction. The more slowly a substrate is hydrolyzed in the absence of metals, the greater the activating effect
Mn2+
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0.1 mM, inhibits prolinase activity in normal erythrocytes against Pro-Ala, Pro-Val, Pro-Met, Pro-Asp
Mn2+
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hydrolysis of the relative poor substrates, Pro-Gly and Gly-Gly is activated, whereas that of Ala-Gly is inhibited
