3.2.2.20: DNA-3-methyladenine glycosylase I
This is an abbreviated version!
For detailed information about DNA-3-methyladenine glycosylase I, go to the full flat file.
Word Map on EC 3.2.2.20
-
3.2.2.20
-
glycosylases
-
abasic
-
excises
-
self-labeling
-
1,n6-ethenoadenine
-
snap-tagged
-
3-methylguanine
- 3.2.2.20
- glycosylases
-
abasic
-
excises
-
self-labeling
- 1,n6-ethenoadenine
-
snap-tagged
- 3-methylguanine
Reaction
Synonyms
3-MeA DNA glycosylase I, 3-methyl adenine DNA glycosylase I, 3-methyladenine DNA glycosylase, 3-methyladenine DNA glycosylase I, 3MeA, 3MeA DNA glycosylase, AAG, Aag 3MeA DNA glycosylase, AlkC, AlkD, APNG, APNG DNA glycosylase, bAag, deoxyribonucleate 3-methyladenine DNA glycosidase I, DNA-3-methyladenine DNA glycosidase I, GI, human m3A DNA glycosylase, m3A DNA glycosylase I, MAG, MAG1, Mag1 3-methyladenine DNA glycosylase, Mag1p, Mag2p, MPG, MpgI, N3-methyladenine DNA glycosylase, protein Tag, TAG, TagA, TagA protein, TagI, Yx1J
ECTree
Advanced search results
Natural Substrates Products
Natural Substrates Products on EC 3.2.2.20 - DNA-3-methyladenine glycosylase I
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REACTION DIAGRAM
3-methyladenine + ?
-
important role in preventing the mutagenic effects of deaminated purines and cyclic etheno adducts
-
?
alkylated DNA + H2O
3-methyladenine + ?
-
important role in preventing the mutagenic effects of deaminated purines and cyclic etheno adducts
-
?
alkylated DNA + H2O
3-methyladenine + ?
smallest member of the helix-hairpin-helix HhH superfamily of DNA glycosylases
-
?
alkylated DNA + H2O
3-methyladenine + ?
-
double-stranded DNA is an effective substrate, enzyme is less efficient in excision of base damage from single-stranded regions transiently formed in DNA during transcription and replication
-
?
alkylated DNA + H2O
3-methyladenine + ?
-
double-stranded DNA is an effective substrate, enzyme is less efficient in excision of base damage from single-stranded regions transiently formed in DNA during transcription and replication
-
?
alkylated DNA + H2O
3-methyladenine + ?
-
reaction of the enzyme with alkylated DNA leads to introduction of apurinic sites but no chain breaks
-
?
alkylated DNA + H2O
3-methyladenine + ?
-
primarily removes N3-methyladenine but also N3-methylguanine from DNA by glycosylic cleavage in the first step of the base excision repair
-
?
alkylated DNA + H2O
3-methyladenine + ?
-
constitutive pathway for repair of DNA damaged by simple alkylating agents such as methylmethanesulfonate and N-methyl-N'-nitro-N-nitrosoguanidine
-
?
alkylated DNA + H2O
3-methyladenine + ?
-
constitutive pathway for repair of DNA damaged by simple alkylating agents such as methylmethanesulfonate and N-methyl-N'-nitro-N-nitrosoguanidine
-
?
alkylated DNA + H2O
3-methyladenine + ?
-
constititively expressed
-
?
alkylated DNA + H2O
3-methyladenine + ?
-
constititively expressed
-
?
alkylated DNA + H2O
3-methyladenine + ?
-
constititively expressed
-
?
alkylated DNA + H2O
3-methyladenine + ?
-
constititively expressed
-
?
alkylated DNA + H2O
3-methyladenine + ?
-
constititively expressed
-
?
alkylated DNA + H2O
3-methyladenine + ?
constititively expressed
-
?
alkylated DNA + H2O
3-methyladenine + ?
Escherichia coli B / ATCC 11303
constititively expressed
-
?
alkylated DNA + H2O
3-methyladenine + ?
-
nuclear transcription factor estrogen receptor alpha interacts with 3-methyladenine DNA glycosylase to modulate transcription and DNA repair, enzyme catalyzes removal of hypoxanthine from DNA, estrogen receptor alpha stabilizes the interaction of the enzyme with hypoxanthine containing DNAand increases the catalytic removal of the modified base
-
?
alkylated DNA + H2O
3-methyladenine + ?
-
50% of DNA alkylation is repaired in the first 60 min after treatment with methyl methanesulfonate
-
-
?
alkylated DNA + H2O
3-methyladenine + ?
-
cellular repair of alkylated DNA base modifications
-
?
alkylated DNA + H2O
3-methyladenine + ?
-
constititively expressed
-
?
alkylated DNA + H2O
3-methyladenine + ?
-
also removes 7-methylguanine
-
?
alkylated DNA + H2O
3-methyladenine + ?
-
initiates the base excision repair pathway by removing damaged bases to create abasic apurinic/apyrimidinic sites
-
?
alkylated DNA + H2O
3-methyladenine + ?
-
highest activity by producing 3-methylguanine
-
-
?
alkylated DNA + H2O
3-methyladenine + ?
Saccharomyces pombe
-
highest activity by producing 3-methylguanine
-
-
?
7-methylguanine + ?
-
50% of DNA alkylation is repaired in the first 60 min after treatment with methyl methanesulfonate
-
-
?
?
-
-
AlkC is involved exclusively in the repair of alkylation damage
-
-
?
additional information
?
-
-
3-methyladenine DNA glycosylase recognizes and excises a broad range of purines damaged by alkylation and oxidative damage, including 3-methyladenine, 7-methylguanine, hypoxanthine, and 1,N6-ethenoadenine
-
-
?