3.2.2.15: DNA-deoxyinosine glycosylase
This is an abbreviated version!
For detailed information about DNA-deoxyinosine glycosylase, go to the full flat file.
Word Map on EC 3.2.2.15
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3.2.2.15
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deamination
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cytosine
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glycosylases
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endonuclease
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deaminase
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abasic
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single-stranded
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activation-induced
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mismatch
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thymine
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duplex
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ung2
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hypermutation
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misincorporation
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uracil-containing
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excises
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deoxyuridine
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uracil-dna
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vpr
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ape1
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extrahelical
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base-excision
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poxvirus
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mispaired
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dutpase
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apyrimidinic
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translesion
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apobec3s
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aid-induced
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aid-dependent
- 3.2.2.15
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deamination
- cytosine
- glycosylases
- endonuclease
- deaminase
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abasic
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single-stranded
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activation-induced
- mismatch
- thymine
- duplex
- ung2
-
hypermutation
-
misincorporation
-
uracil-containing
-
excises
- deoxyuridine
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uracil-dna
- vpr
- ape1
-
extrahelical
-
base-excision
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poxvirus
-
mispaired
- dutpase
-
apyrimidinic
-
translesion
- apobec3s
-
aid-induced
-
aid-dependent
Reaction
Synonyms
bovine hypoxanthine-DNA glycosylase, deoxyribonucleic acid glycosylase, DNA(hypoxanthine) glycohydrolase, DNA(hypoxanthine)glycohydrolase, family 5 UDGb, hypoxanthine DNA glycosylase, hypoxanthine-DNA glycosylase, hypoxanthine-DNA-glycosylase, Phep_0752, SMUG2, UdgB, uracil DNA glycosylase
ECTree
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Substrates Products
Substrates Products on EC 3.2.2.15 - DNA-deoxyinosine glycosylase
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REACTION DIAGRAM
dsDNA + H2O
hypoxanthine + ?
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efficiency of its excision is poor from Hx:T or Hx:C pair but better from an Hx:G pair
-
-
?
hypoxanthine-containing DNA + H2O
hypoxanthine + DNA
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incision activity is increased with age above 12 months of the Wistar and OXYS rats, relation to content of free radicals, overview
-
-
?
hypoxanthine-containing double-stranded DNA + H2O
hypoxanthine + double-stranded DNA with abasic site
hypoxanthine-containing oligodeoxynucleotide + H2O
hypoxanthine + oligodeoxynucleotide
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synthetic mismatched substrate, hyopxanthine-removing, incision activity
-
-
?
xanthine-containing double-stranded DNA + H2O
xanthine + double-stranded DNA with abasic site
DNA + H2O
hypoxanthine + ?
-
preference for double-stranded substrates
liberated from DNA directly as free base, direct cleavage of the base-sugar bonds of dIMP residues in the polymer
?
DNA + H2O
hypoxanthine + ?
-
more efficient on double-stranded than of single-stranded substrates, activity 10-15 times higher, removal of nonconventional residues from DNA
-
-
?
hypoxanthine + double-stranded DNA
strongest activity on the G/I base pair but no activity detected on the C/I base pair
-
-
?
hypoxanthine-containing double-stranded DNA + H2O
hypoxanthine + double-stranded DNA
Thermus thermophilus HB8 / ATCC 27634 / DSM 579
strongest activity on the G/I base pair but no activity detected on the C/I base pair
-
-
?
hypoxanthine + double-stranded DNA with abasic site
-
-
-
?
hypoxanthine-containing double-stranded DNA + H2O
hypoxanthine + double-stranded DNA with abasic site
-
-
-
?
hypoxanthine + ?
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synthetic oligonucleotides
cleaves the dIMP residue into free hypoxanthine and a deoxyribosephosphate residue remaining in DNA
?
uracil + double-stranded DNA with abasic site
-
-
-
?
uracil-containing double-stranded DNA + H2O
uracil + double-stranded DNA with abasic site
-
-
-
?
xanthine + double-stranded DNA with abasic site
-
-
-
?
xanthine-containing double-stranded DNA + H2O
xanthine + double-stranded DNA with abasic site
-
-
-
?
?
-
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DNA repair by initiating a base excision-repair at a damaged or misincorporated residue
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-
?
additional information
?
-
-
no detectable enzyme activity on double-stranded oligonucleotides containing mismatched base pairs
-
-
?
additional information
?
-
-
DNA repair by initiating a base excision-repair at a damaged or misincorporated residue
-
-
?
additional information
?
-
-
DNA repair by initiating a base excision-repair at a damaged or misincorporated residue
-
-
?
additional information
?
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substrate is double-stranded DNA containing uracil or hypoxanthine/xanthine. No substrate: single-stranded DNA
-
-
?
additional information
?
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substrate is double-stranded DNA containing uracil or hypoxanthine/xanthine. No substrate: single-stranded DNA
-
-
?