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Literature summary for 3.2.2.15 extracted from

  • Dianov, G.; Lindahl, T.
    Preferential recognition of I-T base-pairs in the initiation of excision-repair by hypoxanthine-DNA glycosylase (1991), Nucleic Acids Res., 19, 3829-3833.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
Homo sapiens 5634
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
30000
-
-
Escherichia coli
31000
-
SDS-PAGE Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
calf
-
Escherichia coli
-
-
-
Homo sapiens
-
HeLa cells
-

Purification (Commentary)

Purification (Comment) Organism
-
Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
skin fibroblast
-
Bos taurus
-
skin fibroblast HeLa cells nuclear extract Homo sapiens
-
thymus
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA + H2O preference for double-stranded substrates Bos taurus hypoxanthine + ?
-
?
additional information
-
Escherichia coli ?
-
?
additional information
-
Homo sapiens ?
-
?
additional information no detectable enzyme activity on double-stranded oligonucleotides containing mismatched base pairs Bos taurus ?
-
?
polydeoxynucleotides + H2O
-
Escherichia coli hypoxanthine + ?
-
?
polydeoxynucleotides + H2O synthetic oligonucleotides Bos taurus hypoxanthine + ? cleaves the dIMP residue into free hypoxanthine and a deoxyribosephosphate residue remaining in DNA ?