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Literature summary for 3.2.2.15 extracted from
- Substrate specificities and functional characterization of a thermo-tolerant uracil DNA glycosylase (UdgB) from Mycobacterium tuberculosis (2007), DNA Repair, 6, 1517-1528.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| overexpression in Escherichia coli | Mycobacterium tuberculosis |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| dsDNA | AP-site containing | Mycobacterium tuberculosis |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Iron | the enzyme contains Fe-S cluster | Mycobacterium tuberculosis |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mycobacterium tuberculosis | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Mycobacterium tuberculosis |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| dsDNA + H2O | - |
Mycobacterium tuberculosis | ethenocytosine + ? | - |
? | |
| dsDNA + H2O | efficiency of its excision is poor from Hx:T or Hx:C pair but better from an Hx:G pair | Mycobacterium tuberculosis | hypoxanthine + ? | - |
? | |
| dsDNA + H2O | no activity with ssDNA | Mycobacterium tuberculosis | uracil + ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| UdgB | - |
Mycobacterium tuberculosis |
| uracil DNA glycosylase | - |
Mycobacterium tuberculosis |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 60 | - |
10 min, stable below | Mycobacterium tuberculosis |
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