3.2.1.97: endo-alpha-N-acetylgalactosaminidase
This is an abbreviated version!
For detailed information about endo-alpha-N-acetylgalactosaminidase, go to the full flat file.
Word Map on EC 3.2.1.97
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3.2.1.97
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o-linked
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neuraminidase
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o-glycosidic
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n-acetylgalactosamine
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sialidase
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mucin-type
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asialofetuin
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o-glycanase
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bifidobacterial
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thomsen-friedenreich
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analysis
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galbeta1,3galnac
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diplococcus
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synthesis
- 3.2.1.97
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o-linked
- neuraminidase
-
o-glycosidic
- n-acetylgalactosamine
- sialidase
-
mucin-type
- asialofetuin
-
o-glycanase
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bifidobacterial
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thomsen-friedenreich
- analysis
- galbeta1,3galnac
-
diplococcus
- synthesis
Reaction
Synonyms
acetylgalactosaminidase, endo-alpha, D-galactosyl-N-acetyl-alpha-D-galactosamine D-galactosyl-N-acetylgalactosaminohydrolase, EC 3.2.1.110, endo GalNAc-ase S, endo-alpha-acetylgalactosaminidase, endo-alpha-GalNAc-ase, endo-alpha-N-acetylgalactosaminidase, endo-alpha-N-acetylgalactosaminidase S, endo-beta-N-acetylgalactosaminidase, endo-EF, endo-GalNAc-ase S, endoEF, EngBF, EngCP, More, NagBb, SpGH101
ECTree
3.2.1.97 endo-alpha-N-acetylgalactosaminidaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 3.2.1.97 - endo-alpha-N-acetylgalactosaminidase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
3-O-beta-D-galactosyl-N-acetyl-alpha-D-galactosaminyl-L-serine-[protein] + H2O
3-O-beta-D-galactosyl-N-acetyl-alpha-D-galactosamine + L-serine-[protein]
3-O-beta-D-galactosyl-N-acetyl-alpha-D-galactosaminyl-L-threonine-[protein] + H2O
3-O-beta-D-galactosyl-N-acetyl-alpha-D-galactosamine + L-threonine-[protein]
Tn antigen + H2O
?
i.e. N-acetyl-beta-D-galactosaminyl-L-Ser/Thr
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-
?
3-O-beta-D-galactosyl-N-acetyl-alpha-D-galactosaminyl-L-serine-[protein] + H2O
3-O-beta-D-galactosyl-N-acetyl-alpha-D-galactosamine + L-serine-[protein]
-
-
-
-
?
3-O-beta-D-galactosyl-N-acetyl-alpha-D-galactosaminyl-L-serine-[protein] + H2O
3-O-beta-D-galactosyl-N-acetyl-alpha-D-galactosamine + L-serine-[protein]
-
-
-
-
?
3-O-beta-D-galactosyl-N-acetyl-alpha-D-galactosaminyl-L-serine-[protein] + H2O
3-O-beta-D-galactosyl-N-acetyl-alpha-D-galactosamine + L-serine-[protein]
-
-
-
-
?
3-O-beta-D-galactosyl-N-acetyl-alpha-D-galactosaminyl-L-serine-[protein] + H2O
3-O-beta-D-galactosyl-N-acetyl-alpha-D-galactosamine + L-serine-[protein]
-
-
-
-
?
3-O-beta-D-galactosyl-N-acetyl-alpha-D-galactosaminyl-L-serine-[protein] + H2O
3-O-beta-D-galactosyl-N-acetyl-alpha-D-galactosamine + L-serine-[protein]
-
-
-
-
?
3-O-beta-D-galactosyl-N-acetyl-alpha-D-galactosaminyl-L-serine-[protein] + H2O
3-O-beta-D-galactosyl-N-acetyl-alpha-D-galactosamine + L-serine-[protein]
-
-
-
?
3-O-beta-D-galactosyl-N-acetyl-alpha-D-galactosaminyl-L-serine-[protein] + H2O
3-O-beta-D-galactosyl-N-acetyl-alpha-D-galactosamine + L-serine-[protein]
-
-
-
-
?
3-O-beta-D-galactosyl-N-acetyl-alpha-D-galactosaminyl-L-serine-[protein] + H2O
3-O-beta-D-galactosyl-N-acetyl-alpha-D-galactosamine + L-serine-[protein]
-
-
-
?
3-O-beta-D-galactosyl-N-acetyl-alpha-D-galactosaminyl-L-serine-[protein] + H2O
3-O-beta-D-galactosyl-N-acetyl-alpha-D-galactosamine + L-serine-[protein]
-
-
-
-
?
3-O-beta-D-galactosyl-N-acetyl-alpha-D-galactosaminyl-L-threonine-[protein] + H2O
3-O-beta-D-galactosyl-N-acetyl-alpha-D-galactosamine + L-threonine-[protein]
-
-
-
-
?
3-O-beta-D-galactosyl-N-acetyl-alpha-D-galactosaminyl-L-threonine-[protein] + H2O
3-O-beta-D-galactosyl-N-acetyl-alpha-D-galactosamine + L-threonine-[protein]
-
-
-
-
?
3-O-beta-D-galactosyl-N-acetyl-alpha-D-galactosaminyl-L-threonine-[protein] + H2O
3-O-beta-D-galactosyl-N-acetyl-alpha-D-galactosamine + L-threonine-[protein]
-
-
-
-
?
3-O-beta-D-galactosyl-N-acetyl-alpha-D-galactosaminyl-L-threonine-[protein] + H2O
3-O-beta-D-galactosyl-N-acetyl-alpha-D-galactosamine + L-threonine-[protein]
-
-
-
-
?
3-O-beta-D-galactosyl-N-acetyl-alpha-D-galactosaminyl-L-threonine-[protein] + H2O
3-O-beta-D-galactosyl-N-acetyl-alpha-D-galactosamine + L-threonine-[protein]
-
-
-
-
?
3-O-beta-D-galactosyl-N-acetyl-alpha-D-galactosaminyl-L-threonine-[protein] + H2O
3-O-beta-D-galactosyl-N-acetyl-alpha-D-galactosamine + L-threonine-[protein]
-
-
-
?
3-O-beta-D-galactosyl-N-acetyl-alpha-D-galactosaminyl-L-threonine-[protein] + H2O
3-O-beta-D-galactosyl-N-acetyl-alpha-D-galactosamine + L-threonine-[protein]
-
-
-
-
?
3-O-beta-D-galactosyl-N-acetyl-alpha-D-galactosaminyl-L-threonine-[protein] + H2O
3-O-beta-D-galactosyl-N-acetyl-alpha-D-galactosamine + L-threonine-[protein]
-
-
-
?
3-O-beta-D-galactosyl-N-acetyl-alpha-D-galactosaminyl-L-threonine-[protein] + H2O
3-O-beta-D-galactosyl-N-acetyl-alpha-D-galactosamine + L-threonine-[protein]
-
-
-
-
?
additional information
?
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highly induced by porcine gastric mucin
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-
?
additional information
?
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the expression of the gene is highly induced in the presence of mucin
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?
additional information
?
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the expression of the gene is highly induced in the presence of mucin
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-
?
additional information
?
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the enzyme acts very weakly on GalNAcalpha1-UDP and GalNAcalpha(1>3)Galbeta(1>4)Glc and not at all on Neu5Acalpha(2>6)GalNAcalpha1-L-Ser (sialyl Tn antigen)and GalNAcalpha(1>3)(Fucalpha(1>2))Gal (blood group A trisaccharide). In addition, the enzyme very slowly hydrolyzes core-3 (4-nitrophenyl-GlcNAcbeta(1>3)GalNAcalpha1) and core-8 (4-nitrophenyl-Galalpha(1>3)GalNAcalpha1)-type structures but not other core structures
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-
?
additional information
?
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-
EngBF preferably releases Galbeta1-3GalNAc from the core 1-type O-glycan, i.e. Thomsen-Friedenreich antigen or T-antigen, of mucin glycoproteins. EngBF also shows transglycosylation activity of the released disaccharide to other mono- and disaccharides
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-
?
additional information
?
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the enzyme hydrolyses the O-glycosidic bonds in mucin-type O-glycan between alpha-GalNAc and Ser/Thr. EngBF is highly specific for the core 1-type O-glycan to release the disaccharide Galbeta1-3GalNAc
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-
?
additional information
?
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EngBF preferably releases Galbeta1-3GalNAc from the core 1-type O-glycan, i.e. Thomsen-Friedenreich antigen or T-antigen, of mucin glycoproteins. EngBF also shows transglycosylation activity of the released disaccharide to other mono- and disaccharides
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-
?
additional information
?
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SpGH101 specifically removes an O-linked disaccharide Gal-beta-1,3-GalNAc-alpha from glycoproteins
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-
?
additional information
?
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SpGH101 specifically removes an O-linked disaccharide Gal-beta-1,3-GalNAc-alpha from glycoproteins
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-
?
additional information
?
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the enzyme is responsible for catalyzing the liberation of galactosyl beta-1,3-N-acetyl-D-galactosamine linked to serine or threonine residues of mucin-type glycoproteins
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-
?
additional information
?
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enzyme production is induced by mucin, the induction is inhibited by glucose and other easily assimilable carbon sources, as well as by complex nitrogen sources, addition of palmitate, lambda-carrageenan or crude mucin to a mucin-based production medium enhances enzyme production
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-
?
additional information
?
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highly induced by porcine gastric mucin
-
-
?
additional information
?
-
-
enzyme production is induced by mucin, the induction is inhibited by glucose and other easily assimilable carbon sources, as well as by complex nitrogen sources, addition of palmitate, lambda-carrageenan or crude mucin to a mucin-based production medium enhances enzyme production
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-
?
additional information
?
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induced when asialofetuin is the sole carbon source
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-
?
