3.2.1.97: endo-alpha-N-acetylgalactosaminidase

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For detailed information about endo-alpha-N-acetylgalactosaminidase, go to the full flat file.

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Synonyms

acetylgalactosaminidase, endo-alpha, D-galactosyl-N-acetyl-alpha-D-galactosamine D-galactosyl-N-acetylgalactosaminohydrolase, EC 3.2.1.110, endo GalNAc-ase S, endo-alpha-acetylgalactosaminidase, endo-alpha-GalNAc-ase, endo-alpha-N-acetylgalactosaminidase, endo-alpha-N-acetylgalactosaminidase S, endo-beta-N-acetylgalactosaminidase, endo-EF, endo-GalNAc-ase S, endoEF, EngBF, EngCP, More, NagBb, SpGH101

ECTree

     3 Hydrolases

         3.2 Glycosylases

             3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds

                3.2.1.97 endo-alpha-N-acetylgalactosaminidase

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Results	in table
232	AA Sequence
5	Application
1	CAS Registry Number
11	Cloned(Commentary)
2	Crystallization (Commentary)
1	General Information
58	Inhibitors
11	kcat/KM [mM/s]
36	KM Value [mM]
3	Localization
12	Metals/Ions
12	Molecular Weight [Da]
35	Natural Substrates/ Products (Substrates)
77	Organism
7	PDB ID
21	pH Optimum
7	pH Range
4	pH Stability
74	Protein Variants
19	Purification (Commentary)
1	Reaction
1	Reaction Type
53	Reference
13	Source Tissue
5	Specific Activity [micromol/min/mg]
2	Storage Stability
183	Substrates and Products (Substrate)
18	Subunits
65	Synonyms
1	Systematic Name
11	Temperature Optimum [°C]
10	Temperature Stability [°C]
21	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 3.2.1.97 - endo-alpha-N-acetylgalactosaminidase

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SYSTEMATIC NAME

IUBMB Comments

glycopeptide-D-galactosyl-N-acetyl-alpha-D-galactosamine D-galactosyl-N-acetyl-galactosaminohydrolase

The enzyme catalyses the liberation of Gal-(1->3)-beta-GalNAc alpha-linked to serine or threonine residues of mucin-type glycoproteins. EngBF from the bacterium Bifidobacterium longum specifically acts on core 1-type O-glycan to release the disaccharide Gal-(1->3)-beta-GalNAc. The enzymes from the bacteria Clostridium perfringens, Enterococcus faecalis, Propionibacterium acnes and Alcaligenes faecalis show broader specificity (e.g. they can also release the core 2 trisaccharide Gal-(1->3)-beta-(GlcNAc-(1->6)-beta)-GalNAc or the core 3 disaccharide GlcNAc-(1->3)-beta-GalNAc) [1,2]. The enzyme may play an important role in the degradation and utilization of mucins having core 1 O-glycan.